chr12:125,098,677–125,099,386

chr12 : 125,098,677 – 125,099,386

709 bp 99 TFs 6 linked genes

This 709 bp open chromatin element is linked to 6 target genes and is bound by 99 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
AACS		1.5 kb	Proximal	Proximity
TMEM132B		87.3 kb	Distal	Multiome
BRI3BP		105.3 kb	Distal	Multiome
DHX37		110.0 kb	Distal	Multiome
UBC		184.4 kb	Distal	Multiome
SCARB1		235.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

99 transcription factors

ARID1A 1 dataset

ChIP LNCaP_r1881 GSE94682.ARID1A.LNCaP_r1881 213 bp overlap

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 303 bp overlap

ChIP K562 ENCFF938UXQ 538 bp overlap

ATF4 2 datasets

ChIP Jurkat_ZBTB1-KO_Asp-deprivation GSE145783.ATF4.Jurkat_ZBTB1-KO_Asp-deprivation 170 bp overlap

ChIP Jurkat_ZBTB1-KO_Asp-deprivation GSE145783.ATF4.Jurkat_ZBTB1-KO_Asp-deprivation 260 bp overlap

Arid3a 2 datasets

Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap

Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap

BHLHE22 2 datasets

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

ChIP K-562 GSE140325.BRD3.K-562 148 bp overlap

BRD4 2 datasets

ChIP Jurkat GSE83777.BRD4.Jurkat 614 bp overlap

ChIP RH4_shscr GSE140115.BRD4.RH4_shscr 271 bp overlap

Bcl11B 3 datasets

Motif DE_48h DE_48h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_60h DE_60h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_72h DE_72h-Bcl11B_MA1989.2 9 bp overlap

CBFA2T2 1 dataset

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 299 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 403 bp overlap

ChIP K562 ENCFF673OEZ 133 bp overlap

ChIP Jurkat GSE83777.CDK7.Jurkat 245 bp overlap

CDK9 2 datasets

ChIP MOLT-4_DMSO GSE79288.CDK9.MOLT-4_DMSO 520 bp overlap

ChIP MOLT-4_JQ1 GSE79288.CDK9.MOLT-4_JQ1 535 bp overlap

CEBPD 1 dataset

ChIP K-562 ENCSR000BVY.CEBPD.K-562 132 bp overlap

CUX1 3 datasets

Motif DE_48h DE_48h-CUX1_MA0754.3 9 bp overlap

Motif DE_60h DE_60h-CUX1_MA0754.3 9 bp overlap

Motif DE_72h DE_72h-CUX1_MA0754.3 9 bp overlap

Motif DE_48h DE_48h-Dux_MA0611.3 11 bp overlap

Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap

ChIP NALM-6 GSE126300.EBF1.NALM-6 284 bp overlap

ChIP HEK293 ENCFF336LFH 425 bp overlap

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap

ELK1::SREBF2 3 datasets

Motif DE_48h DE_48h-ELK1SREBF2_MA1933.2 15 bp overlap

Motif DE_60h DE_60h-ELK1SREBF2_MA1933.2 15 bp overlap

Motif DE_72h DE_72h-ELK1SREBF2_MA1933.2 15 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 284 bp overlap

ChIP Jurkat GSE49091.ERG.Jurkat 215 bp overlap

ChIP TSU-1621MT_ATRA GSE60477.ERG.TSU-1621MT_ATRA 266 bp overlap

ChIP aortic-endothelial-cell_D1 GSE139377.ERG.aortic-endothelial-cell_D1 177 bp overlap

ChIP aortic-endothelial-cell_D49 GSE139377.ERG.aortic-endothelial-cell_D49 167 bp overlap

ESRRG 1 dataset

ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 69 bp overlap

Motif DE_48h DE_48h-ETV6_MA0645.2 9 bp overlap

Motif DE_48h DE_48h-ETV7_MA1708.2 9 bp overlap

ChIP Jurkat_KO GSE147198.EZH2.Jurkat_KO 364 bp overlap

Motif DE_48h DE_48h-Elf5_MA0136.4 8 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 542 bp overlap

ChIP DE DE-FOXA2-2 482 bp overlap

FOXO1-PAX3 2 datasets

ChIP RH4_DMSO-6H GSE116344.FOXO1-PAX3.RH4_DMSO-6H 273 bp overlap

ChIP RH4_Entinostat-6H GSE116344.FOXO1-PAX3.RH4_Entinostat-6H 250 bp overlap

GATA1 6 datasets

ChIP CD34_ERYTH_BIO GSE29194.GATA1.CD34_ERYTH_BIO 320 bp overlap

ChIP CD34_ERYTH_BMP GSE29194.GATA1.CD34_ERYTH_BMP 144 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 235 bp overlap

ChIP K-562 ENCSR000EFT.GATA1.K-562 125 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 225 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 209 bp overlap

GATA1::TAL1 5 datasets

Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 3 datasets

ChIP CD34_ACY957 GSE60792.GATA2.CD34_ACY957 291 bp overlap

ChIP SKH1 GSE87283.GATA2.SKH1 436 bp overlap

ChIP TF1 GSE73207.GATA2.TF1 231 bp overlap

GATA3 2 datasets

ChIP Jurkat GSE76181.GATA3.Jurkat 571 bp overlap

ChIP Jurkat GSE68976.GATA3.Jurkat 268 bp overlap

GATA4 7 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 185 bp overlap

ChIP DE DE-GATA4-1 669 bp overlap

ChIP DE DE-GATA4-2 616 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 263 bp overlap

ChIP foregut GSE117136.GATA4.foregut 442 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 336 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 380 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 531 bp overlap

ChIP DE DE-GATA6-2 637 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 438 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 540 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 425 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 709 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 577 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 570 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 638 bp overlap

ChIP foregut GSE117136.GATA6.foregut 477 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 265 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 344 bp overlap

GRHL2 3 datasets

Motif DE_48h DE_48h-GRHL2_MA1105.3 8 bp overlap

Motif DE_60h DE_60h-GRHL2_MA1105.3 8 bp overlap

Motif DE_72h DE_72h-GRHL2_MA1105.3 8 bp overlap

HDAC2 2 datasets

ChIP RH4_DMSO-6H GSE116344.HDAC2.RH4_DMSO-6H 205 bp overlap

ChIP RH4_Entinostat-6H GSE116344.HDAC2.RH4_Entinostat-6H 233 bp overlap

ChIP MO91 GSE45852.HSF1.MO91 176 bp overlap

Hand1::Tcf3 1 dataset

Motif DE_48h DE_48h-Hand1Tcf3_MA0092.2 9 bp overlap

Hnf1A 3 datasets

Motif DE_48h DE_48h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_72h DE_72h-Hnf1A_MA1991.2 10 bp overlap

ChIP K-562 ENCSR005NMT.ID3.K-562 380 bp overlap

IKZF2 1 dataset

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

Irf1 2 datasets

Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 279 bp overlap

ChIP K-562 GSE142227.LDB1.K-562 360 bp overlap

ChIP Jurkat GSE94391.LMO1.Jurkat 562 bp overlap

ChIP TSU-1621MT GSE60477.LMO2.TSU-1621MT 240 bp overlap

ChIP Jurkat GSE59657.MED1.Jurkat 303 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

ChIP RH4 GSE155861.MTA2.RH4 678 bp overlap

ChIP DU528 GSE94000.MYB.DU528 237 bp overlap

ChIP Jurkat GSE59657.MYB.Jurkat 630 bp overlap

ChIP MOLT-3 GSE59657.MYB.MOLT-3 618 bp overlap

ChIP PF-382 GSE94000.MYB.PF-382 540 bp overlap

MYOD1 1 dataset

ChIP RH4 GSE83726.MYOD1.RH4 301 bp overlap

ChIP RH4 GSE83726.MYOG.RH4 206 bp overlap

Msgn1 1 dataset

Motif DE_48h DE_48h-Msgn1_MA1524.3 10 bp overlap

NFATC1 1 dataset

ChIP GM12878 ENCFF023CAZ 65 bp overlap

NFATC3 5 datasets

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NOTCH1 1 dataset

ChIP HPBALL GSE39263.NOTCH1.HPBALL 204 bp overlap

NR3C1 2 datasets

ChIP NALM-6 GSE67046.NR3C1.NALM-6 316 bp overlap

ChIP NALM-6_CASP1 GSE67046.NR3C1.NALM-6_CASP1 169 bp overlap

Neurod2 2 datasets

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Nfatc1 5 datasets

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Nr2e3 3 datasets

Motif DE_48h DE_48h-Nr2e3_MA0164.2 6 bp overlap

Motif DE_60h DE_60h-Nr2e3_MA0164.2 6 bp overlap

Motif DE_72h DE_72h-Nr2e3_MA0164.2 6 bp overlap

OSR2 3 datasets

Motif DE_48h DE_48h-OSR2_MA1646.2 8 bp overlap

Motif DE_60h DE_60h-OSR2_MA1646.2 8 bp overlap

Motif DE_72h DE_72h-OSR2_MA1646.2 8 bp overlap

Olig2 2 datasets

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 280 bp overlap

ChIP NALM-6 GSE126300.PAX5.NALM-6 287 bp overlap

PAX6 2 datasets

Motif DE_48h DE_48h-PAX6_MA0069.1 14 bp overlap

Motif DE_60h DE_60h-PAX6_MA0069.1 14 bp overlap

ChIP H9_DOX GSE98976.PAX7.H9_DOX 279 bp overlap

Prdm4 2 datasets

Motif DE_48h DE_48h-Prdm4_MA1647.3 11 bp overlap

Motif DE_60h DE_60h-Prdm4_MA1647.3 11 bp overlap

ChIP HeLa-B2_DMSO GSE24518.RELA.HeLa-B2_DMSO 192 bp overlap

RUNX1 5 datasets

ChIP Jurkat GSE68976.RUNX1.Jurkat 566 bp overlap

ChIP Jurkat GSE76181.RUNX1.Jurkat 480 bp overlap

ChIP ME-1_CBFB-MYH11-KD GSE117138.RUNX1.ME-1_CBFB-MYH11-KD 230 bp overlap

ChIP ME-1_Con GSE128771.RUNX1.ME-1_Con 230 bp overlap

ChIP NALM-6 GSE126300.RUNX1.NALM-6 373 bp overlap

SCRT2 3 datasets

Motif DE_48h DE_48h-SCRT2_MA0744.3 10 bp overlap

Motif DE_60h DE_60h-SCRT2_MA0744.3 10 bp overlap

Motif DE_72h DE_72h-SCRT2_MA0744.3 10 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 237 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 670 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 532 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 280 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 709 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 709 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 262 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 493 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 585 bp overlap

Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap

STAT1 1 dataset

ChIP SET-2_cortistatin-A GSE100566.STAT1.SET-2_cortistatin-A 326 bp overlap

Sox1 3 datasets

Motif DE_48h DE_48h-Sox1_MA0870.1 15 bp overlap

Motif DE_60h DE_60h-Sox1_MA0870.1 15 bp overlap

Motif DE_72h DE_72h-Sox1_MA0870.1 15 bp overlap

Motif DE_48h DE_48h-Spi1_MA0080.7 13 bp overlap

Stat2 2 datasets

Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Stat5a 3 datasets

Motif DE_48h DE_48h-Stat5a_MA1624.2 9 bp overlap

Motif DE_60h DE_60h-Stat5a_MA1624.2 9 bp overlap

Motif DE_72h DE_72h-Stat5a_MA1624.2 9 bp overlap

TAL1 10 datasets

ChIP K-562 ENCSR106FRG.TAL1.K-562 240 bp overlap

ChIP K-562 ENCSR000EHB.TAL1.K-562 132 bp overlap

ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 259 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 174 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 326 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 218 bp overlap

ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 144 bp overlap

ChIP K562 ENCFF620GMX 385 bp overlap

ChIP MOLT-3 GSE59657.TAL1.MOLT-3 625 bp overlap

ChIP ProEs GSE59087.TAL1.ProEs 232 bp overlap

TCF12 2 datasets

ChIP K-562 ENCSR744WOO.TCF12.K-562 279 bp overlap

ChIP K562 ENCFF931DJY 391 bp overlap

ChIP RCH-ACV GSE85988.TCF3.RCH-ACV 337 bp overlap

TEAD4 1 dataset

ChIP K562 ENCFF673NIK 365 bp overlap

TFAP4 2 datasets

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap

Tcf12 2 datasets

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 2 datasets

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

ZBTB1 2 datasets

ChIP Jurkat_ZBTB1-KO_Asp-deprivation_cDNA GSE145783.ZBTB1.Jurkat_ZBTB1-KO_Asp-deprivation_cDNA 293 bp overlap

ChIP Jurkat_ZBTB1-KO_cDNA GSE145783.ZBTB1.Jurkat_ZBTB1-KO_cDNA 215 bp overlap

ZBTB7A 2 datasets

ChIP HUDEP-2 GSE103445.ZBTB7A.HUDEP-2 331 bp overlap

ChIP K-562 GSE103445.ZBTB7A.K-562 234 bp overlap

ZC3H8 1 dataset

ChIP HCT-116 GSE47938.ZC3H8.HCT-116 197 bp overlap

ZNF175 1 dataset

Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap

ZNF449 1 dataset

ChIP HEK293 GSE76494.ZNF449.HEK293 123 bp overlap

ZNF558 3 datasets

Motif DE_48h DE_48h-ZNF558_MA2335.1 29 bp overlap

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

Motif DE_72h DE_72h-ZNF558_MA2335.1 29 bp overlap

ZNF768 3 datasets

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap

Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap

Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap

ZNF85 3 datasets

Motif DE_48h DE_48h-ZNF85_MA1720.2 12 bp overlap

Motif DE_60h DE_60h-ZNF85_MA1720.2 12 bp overlap

Motif DE_72h DE_72h-ZNF85_MA1720.2 12 bp overlap