Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nucleobase-containing compound biosynthetic process; and protein homooligomerization. Located in nuclear body and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:64,293,957–64,295,260 | 208.8 kb | Distal (>10kb) Multiome | 474 | |
| chr14:64,337,827–64,339,391 | 164.9 kb | Distal (>10kb) Multiome | 825 | |
| chr14:64,387,230–64,388,939 | 115.6 kb | Distal (>10kb) Multiome | 902 | |
| chr14:64,391,271–64,391,891 | 112.2 kb | Distal (>10kb) Multiome | 182 | |
| chr14:64,465,087–64,466,161 | 38.2 kb | Distal (>10kb) Multiome | 490 | |
| chr14:64,502,980–64,505,716 | 99 bp | At TSS Multiome | 1045 | |
| chr14:64,508,924–64,509,409 | 5.5 kb | Proximal (<10kb) Multiome | 117 | |
| chr14:64,511,153–64,511,336 | 7.4 kb | Proximal (<10kb) | 180 | |
| chr14:64,539,520–64,541,644 | 36.8 kb | Distal (>10kb) Multiome | 722 | |
| chr14:64,549,785–64,550,422 | 46.3 kb | Distal (>10kb) Multiome | 234 | |
| chr14:64,645,238–64,645,989 | 141.9 kb | Distal (>10kb) Multiome | 252 | |
| chr14:64,657,975–64,659,082 | 154.9 kb | Distal (>10kb) Multiome | 104 | |
| chr14:64,688,830–64,689,973 | 185.5 kb | Distal (>10kb) Multiome | 173 | |
| chr14:64,702,676–64,705,752 | 200.7 kb | Distal (>10kb) Multiome | 771 | |
| chr14:64,708,103–64,708,910 | 204.7 kb | Distal (>10kb) Multiome | 355 | |
| chr14:64,764,629–64,765,271 | 261.2 kb | Distal (>10kb) Multiome | 313 |
Genomic view of the ZBTB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.