ZC3H8

zinc finger CCCH-type containing 8 | Fliz1, ZC3HDC8

Enables RNA binding activity. Involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of DNA-templated transcription; and snRNA transcription. Located in Cajal body; euchromatin; and histone locus body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7

Biological processes 31 terms

Cajal body (GO:0015030)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (GO:0001162)T cell homeostasis (GO:0043029)chromatin (GO:0000785)euchromatin (GO:0000791)histone locus body (GO:0035363)metal ion binding (GO:0046872)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription, elongation (GO:0032785)negative regulation of T cell differentiation in thymus (GO:0033085)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of snRNA transcription by RNA polymerase II (GO:1905382)positive regulation of thymocyte apoptotic process (GO:0070245)positive regulation of transcription by RNA polymerase III (GO:0045945)protein binding (GO:0005515)response to antibiotic (GO:0046677)snRNA transcription by RNA polymerase II (GO:0042795)snRNA transcription by RNA polymerase III (GO:0042796)transcription elongation factor complex (GO:0008023)

Expression (TPM)

TFs regulating ZC3H8 0 TFs

Transcription factors with Perturb-seq knockdown data for ZC3H8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZC3H8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:112,047,188–112,048,562	207.2 kb	Distal (>10kb) Multiome	275
chr2:112,053,884–112,054,856	200.2 kb	Distal (>10kb) Multiome	492
chr2:112,054,956–112,056,432	199.8 kb	Distal (>10kb) Multiome	968
chr2:112,181,502–112,182,275	73.2 kb	Distal (>10kb) Multiome	174
chr2:112,254,532–112,255,517	36 bp	At TSS Multiome	915
chr2:112,259,521–112,259,898	4.5 kb	Proximal (<10kb)	480
chr2:112,275,156–112,276,567	21.2 kb	Distal (>10kb) Multiome	1201
chr2:112,480,926–112,482,608	226.1 kb	Distal (>10kb) Multiome	860
chr2:112,541,785–112,542,849	287.2 kb	Distal (>10kb) Multiome	1070

Genome Browser

Genomic view of the ZC3H8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.