The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for ID3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ID3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ID3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:23,343,731–23,344,999 | 215.0 kb | Distal (>10kb) Multiome | 939 | |
| chr1:23,367,863–23,369,864 | 191.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr1:23,370,752–23,371,596 | 188.4 kb | Distal (>10kb) Multiome | 344 | |
| chr1:23,403,774–23,404,231 | 155.5 kb | Distal (>10kb) Multiome | 536 | |
| chr1:23,436,460–23,437,402 | 122.6 kb | Distal (>10kb) Multiome | 248 | |
| chr1:23,483,306–23,485,071 | 75.1 kb | Distal (>10kb) Multiome | 659 | |
| chr1:23,530,568–23,531,711 | 28.2 kb | Distal (>10kb) Multiome | 775 | |
| chr1:23,539,704–23,540,280 | 19.5 kb | Distal (>10kb) Multiome | 668 | |
| chr1:23,554,367–23,556,627 | 4.6 kb | Proximal (<10kb) Multiome | 961 | |
| chr1:23,556,640–23,557,066 | 2.4 kb | Proximal (<10kb) | 325 | |
| chr1:23,558,135–23,559,925 | 64 bp | At TSS Multiome | 932 | |
| chr1:23,562,351–23,562,663 | 2.9 kb | Proximal (<10kb) | 594 | |
| chr1:23,598,114–23,599,073 | 39.1 kb | Distal (>10kb) Multiome | 329 | |
| chr1:23,691,587–23,692,258 | 132.3 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr1:23,742,958–23,744,137 | 183.8 kb | Distal (>10kb) Multiome | 802 | |
| chr1:23,777,908–23,778,814 | 218.9 kb | Distal (>10kb) Multiome | 849 | |
| chr1:23,790,777–23,791,448 | 231.6 kb | Distal (>10kb) Multiome | 637 | |
| chr1:23,799,493–23,801,538 | 241.4 kb | Distal (>10kb) Multiome | 922 | |
| chr1:23,825,075–23,825,633 | 265.9 kb | Distal (>10kb) Multiome | 867 |
Genomic view of the ID3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.