HSF1
heat shock transcription factor 1 | HSTF1

The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

Member of: DE-6 Developmental clusters: GC2
Biological processes 78 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)Hsp90 protein binding (GO:0051879)MAPK cascade (GO:0000165)PML body (GO:0016605)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (GO:0001162)cellular response to cadmium ion (GO:0071276)cellular response to copper ion (GO:0071280)cellular response to diamide (GO:0072738)cellular response to gamma radiation (GO:0071480)cellular response to heat (GO:0034605)cellular response to heat (GO:0034605)cellular response to sodium arsenite (GO:1903936)cellular response to unfolded protein (GO:0034620)centrosome (GO:0005813)centrosome (GO:0005813)chromatin (GO:0000785)chromatin DNA binding (GO:0031490)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)general transcription initiation factor binding (GO:0140296)heat shock protein binding (GO:0031072)identical protein binding (GO:0042802)identical protein binding (GO:0042802)kinetochore (GO:0000776)mitotic spindle pole (GO:0097431)negative regulation of double-strand break repair via nonhomologous end joining (GO:2001033)negative regulation of protein-containing complex assembly (GO:0031333)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear stress granule (GO:0097165)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of gene expression (GO:0010628)positive regulation of macrophage differentiation (GO:0045651)positive regulation of mitotic cell cycle (GO:0045931)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)pronucleus (GO:0045120)protein binding (GO:0005515)protein folding chaperone complex (GO:0101031)protein heterodimerization activity (GO:0046982)protein kinase binding (GO:0019901)protein-containing complex (GO:0032991)protein-containing complex assembly (GO:0065003)regulation of DNA-templated transcription (GO:0006355)regulation of cellular response to heat (GO:1900034)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)ribonucleoprotein complex (GO:1990904)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)spindle pole (GO:0000922)transcription cis-regulatory region binding (GO:0000976)translation elongation factor binding (GO:0061770)
Expression (TPM)
HSF1 — as a Regulated Gene

TFs regulating HSF1 0 TFs

Transcription factors with Perturb-seq knockdown data for HSF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HSF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:144,049,063–144,051,761 240.9 kb Distal (>10kb) Multiome 342
chr8:144,060,259–144,061,087 230.8 kb Distal (>10kb) Multiome 727
chr8:144,078,142–144,079,235 213.0 kb Distal (>10kb) Multiome 912
chr8:144,082,187–144,083,105 209.0 kb Distal (>10kb) Multiome 763
chr8:144,094,454–144,095,491 196.7 kb Distal (>10kb) Multiome 798
chr8:144,103,485–144,105,242 187.3 kb Distal (>10kb) Multiome 1033
chr8:144,108,038–144,108,663 183.2 kb Distal (>10kb) Multiome 137
chr8:144,137,565–144,138,500 153.9 kb Distal (>10kb) Multiome HiCAR 817
chr8:144,146,820–144,149,073 143.7 kb Distal (>10kb) Multiome 790
chr8:144,266,293–144,267,098 25.1 kb Distal (>10kb) Multiome 162
chr8:144,290,981–144,292,410 93 bp At TSS Multiome 716
chr8:144,315,833–144,316,450 24.5 kb Distal (>10kb) Multiome HiCAR 396
chr8:144,325,768–144,327,719 35.3 kb Distal (>10kb) Multiome HiCAR 1016
chr8:144,331,281–144,333,847 40.4 kb Distal (>10kb) Multiome 406
chr8:144,336,102–144,339,119 45.3 kb Distal (>10kb) Multiome 922
chr8:144,353,907–144,355,227 63.0 kb Distal (>10kb) Multiome 280
chr8:144,358,142–144,359,070 67.0 kb Distal (>10kb) Multiome 719
chr8:144,369,349–144,369,916 78.1 kb Distal (>10kb) Multiome 204
chr8:144,372,497–144,372,883 81.1 kb Distal (>10kb) Multiome 160
chr8:144,372,993–144,375,084 82.4 kb Distal (>10kb) Multiome 903
chr8:144,408,968–144,410,189 117.8 kb Distal (>10kb) Multiome 920
chr8:144,427,691–144,429,571 137.0 kb Distal (>10kb) Multiome 1000
chr8:144,443,691–144,445,047 152.8 kb Distal (>10kb) Multiome 743
chr8:144,462,568–144,463,422 171.3 kb Distal (>10kb) Multiome 548
chr8:144,463,885–144,468,178 174.2 kb Distal (>10kb) Multiome 910
chr8:144,471,960–144,474,391 180.9 kb Distal (>10kb) Multiome 482
chr8:144,474,517–144,476,543 184.3 kb Distal (>10kb) Multiome 321
chr8:144,477,277–144,478,749 186.4 kb Distal (>10kb) Multiome 679
chr8:144,478,851–144,479,509 187.7 kb Distal (>10kb) Multiome 392
chr8:144,483,979–144,484,843 192.8 kb Distal (>10kb) Multiome 125
chr8:144,495,748–144,496,431 204.5 kb Distal (>10kb) Multiome 131
chr8:144,500,182–144,501,505 209.4 kb Distal (>10kb) Multiome 484
chr8:144,507,995–144,510,268 217.3 kb Distal (>10kb) Multiome 1067
chr8:144,517,168–144,518,442 226.3 kb Distal (>10kb) Multiome 637
chr8:144,521,935–144,523,450 230.9 kb Distal (>10kb) Multiome 663
chr8:144,524,105–144,525,099 233.1 kb Distal (>10kb) Multiome 264
chr8:144,526,399–144,529,305 235.5 kb Distal (>10kb) Multiome 934
chr8:144,529,455–144,530,630 238.6 kb Distal (>10kb) Multiome 284
chr8:144,580,290–144,581,657 289.2 kb Distal (>10kb) Multiome 271

Genome Browser

Genomic view of the HSF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:144,039,063 – 144,591,657
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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