chr12 : 25,256,800 – 25,257,292
492 bp 97 TFs 1 linked gene
This 492 bp open chromatin element is linked to KRAS and is bound by 97 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
KRAS 5.9 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr12:25,251,800 – 25,262,292
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
97 transcription factors
Source
Cell type
AR 1 dataset
ChIP LNCaP_G87R_shFOXA1_Ethanol GSE128883.AR.LNCaP_G87R_shFOXA1_Ethanol 165 bp overlap
ARID1A 2 datasets
ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 379 bp overlap
ChIP MCF-7_DCDT GSE123284.ARID1A.MCF-7_DCDT 280 bp overlap
ASH2L 2 datasets
ChIP VCaP_R1881 GSE60841.ASH2L.VCaP_R1881 188 bp overlap
ChIP WA01 ENCSR850KIP.ASH2L.WA01 466 bp overlap
ATF3 1 dataset
ChIP WA01 ENCSR000BKC.ATF3.WA01 226 bp overlap
ATF4 1 dataset
Motif ES_0h ES_0h-ATF4_MA0833.3 10 bp overlap
BHLHE22 1 dataset
Motif ES_0h ES_0h-BHLHE22_MA1635.2 6 bp overlap
BRD4 4 datasets
ChIP HCC1806_100nMtrametinib300nMJQ1_24h GSE87418.BRD4.HCC1806_100nMtrametinib300nMJQ1_24h 261 bp overlap
ChIP LNCaP-C4-2_F133V GSE88871.BRD4.LNCaP-C4-2_F133V 287 bp overlap
ChIP VCaP GSE148358.BRD4.VCaP 242 bp overlap
ChIP keratinocyte GSE140992.BRD4.keratinocyte 377 bp overlap
CBFA2T2 2 datasets
ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 219 bp overlap
ChIP K562 ENCFF963TXY 324 bp overlap
CEBPG 1 dataset
Motif ES_0h ES_0h-CEBPG_MA1636.2 10 bp overlap
CREBBP 1 dataset
ChIP MCF-7 ERP000901.CREBBP.MCF-7 136 bp overlap
CTBP1 1 dataset
ChIP MCF-7 ENCSR636EYA.CTBP1.MCF-7 373 bp overlap
CTCF 3 datasets
ChIP MCF-7 ENCFF198DQX 231 bp overlap
ChIP MCF-7 ENCFF494VXA 231 bp overlap
ChIP hESC_NAIVE GSE69646.CTCF.hESC_NAIVE 303 bp overlap
Cebpa 3 datasets
ChIP BLaER1 ENCFF093OYK 254 bp overlap
ChIP BLaER1 ENCFF262VBH 280 bp overlap
ChIP BLaER1 ENCFF335XTP 176 bp overlap
DPF1 1 dataset
ChIP MCF-7 GSE97661.DPF1.MCF-7 269 bp overlap
DPF2 1 dataset
ChIP MCF-7 ENCSR234VCE.DPF2.MCF-7 307 bp overlap
ERG 1 dataset
ChIP VCaP_R1881 GSE49091.ERG.VCaP_R1881 196 bp overlap
ESR1 4 datasets
ChIP MCF-7_E2 GSE14664.ESR1.MCF-7_E2 232 bp overlap
ChIP MCF-7_E2 GSE14664.ESR1.MCF-7_E2 94 bp overlap
ChIP MCF-7_E2+4OHT_SRC-3 GSE119702.ESR1.MCF-7_E2+4OHT_SRC-3 227 bp overlap
ChIP MCF-7_SRC3_OHT GSE119702.ESR1.MCF-7_SRC3_OHT 227 bp overlap
FEZF1 3 datasets
ChIP HEK293 ENCFF528YED 330 bp overlap
ChIP HEK293 ENCSR827NWO.FEZF1.HEK293 389 bp overlap
ChIP HEK293 GSE76494.FEZF1.HEK293 320 bp overlap
FIGLA 1 dataset
Motif ES_0h ES_0h-FIGLA_MA0820.2 6 bp overlap
FOXA1 4 datasets
ChIP LNCaP_DHT24H GSE58428.FOXA1.LNCaP_DHT24H 234 bp overlap
ChIP LNCaP_S2101-4H GSE114266.FOXA1.LNCaP_S2101-4H 222 bp overlap
ChIP primary-breast-cancer_B1_DSG GSE114737.FOXA1.primary-breast-cancer_B1_DSG 206 bp overlap
ChIP prostate_2480 GSE130408.FOXA1.prostate_2480 172 bp overlap
GATA6 1 dataset
ChIP HUG1N GSE51936.GATA6.HUG1N 492 bp overlap
GFI1 2 datasets
ChIP HepG2 ENCFF472INF 408 bp overlap
ChIP HepG2 ENCFF472INF 104 bp overlap
GRHL1 1 dataset
ChIP MCF-7 GSE140185.GRHL1.MCF-7 312 bp overlap
GRHL2 9 datasets
ChIP HBE GSE46194.GRHL2.HBE 401 bp overlap
ChIP LNCaP GSE80256.GRHL2.LNCaP 242 bp overlap
ChIP MCF-7 GSE109820.GRHL2.MCF-7 338 bp overlap
ChIP MCF-7 GSE99680.GRHL2.MCF-7 226 bp overlap
ChIP MCF-7-WS8_VEH GSE113092.GRHL2.MCF-7-WS8_VEH 324 bp overlap
ChIP MCF-7_E2_45min GSE109820.GRHL2.MCF-7_E2_45min 357 bp overlap
ChIP OVCA429 GSE71018.GRHL2.OVCA429 249 bp overlap
ChIP OVCAR-3 GSE71018.GRHL2.OVCAR-3 203 bp overlap
ChIP T-47D GSE99680.GRHL2.T-47D 306 bp overlap
GTF2F1 3 datasets
ChIP Hep-G2 GSE120104.GTF2F1.Hep-G2 179 bp overlap
ChIP Hep-G2 ENCSR382PVA.GTF2F1.Hep-G2 200 bp overlap
ChIP MCF-7 ENCSR557JTZ.GTF2F1.MCF-7 309 bp overlap
HOXB13 17 datasets
ChIP prostate-cancer_PDX_141 GSE130408.HOXB13.prostate-cancer_PDX_141 61 bp overlap
ChIP prostate-cancer_PDX_167 GSE130408.HOXB13.prostate-cancer_PDX_167 206 bp overlap
ChIP prostate-cancer_PDX_170-2 GSE130408.HOXB13.prostate-cancer_PDX_170-2 88 bp overlap
ChIP prostate-cancer_PDX_70 GSE130408.HOXB13.prostate-cancer_PDX_70 93 bp overlap
ChIP prostate_2480_T GSE130408.HOXB13.prostate_2480_T 241 bp overlap
ChIP prostate_2483 GSE130408.HOXB13.prostate_2483 182 bp overlap
ChIP prostate_2483_T GSE130408.HOXB13.prostate_2483_T 259 bp overlap
ChIP prostate_2484 GSE130408.HOXB13.prostate_2484 248 bp overlap
ChIP prostate_P13_T GSE130408.HOXB13.prostate_P13_T 298 bp overlap
ChIP prostate_P19 GSE130408.HOXB13.prostate_P19 194 bp overlap
ChIP prostate_P23_T GSE130408.HOXB13.prostate_P23_T 233 bp overlap
ChIP prostate_P25 GSE130408.HOXB13.prostate_P25 398 bp overlap
ChIP prostate_P27 GSE130408.HOXB13.prostate_P27 189 bp overlap
ChIP prostate_P27_T GSE130408.HOXB13.prostate_P27_T 200 bp overlap
ChIP prostate_P29_T GSE130408.HOXB13.prostate_P29_T 261 bp overlap
ChIP prostate_P5_T GSE130408.HOXB13.prostate_P5_T 214 bp overlap
ChIP prostate_P7_T GSE130408.HOXB13.prostate_P7_T 160 bp overlap
KLF4 1 dataset
ChIP keratinocyte_diff GSE57702.KLF4.keratinocyte_diff 133 bp overlap
LIN54 1 dataset
ChIP Hep-G2 ENCSR597MCV.LIN54.Hep-G2 202 bp overlap
MAF1 1 dataset
ChIP THP-1_monocytes GSE96800.MAF1.THP-1_monocytes 153 bp overlap
MAX 1 dataset
ChIP WTC11 ENCFF223QFY 348 bp overlap
MEIS1 1 dataset
Motif ES_0h ES_0h-MEIS1_MA0498.3 5 bp overlap
MITF 7 datasets
ChIP 501-mel GSE137522.MITF.501-mel 376 bp overlap
ChIP 501-mel GSE61965.MITF.501-mel 285 bp overlap
ChIP 501-mel_20ng_K243R GSE137522.MITF.501-mel_20ng_K243R 377 bp overlap
ChIP 501-mel_K243Q GSE137522.MITF.501-mel_K243Q 354 bp overlap
ChIP 501-mel_K243R GSE137522.MITF.501-mel_K243R 226 bp overlap
ChIP K-562 ENCSR797SWM.MITF.K-562 388 bp overlap
ChIP K562 ENCFF731XJJ 319 bp overlap
MXD4 1 dataset
ChIP Hep-G2 ENCSR441KFW.MXD4.Hep-G2 159 bp overlap
MYBL2 1 dataset
ChIP Hep-G2 ENCSR581KCO.MYBL2.Hep-G2 182 bp overlap
NANOG 1 dataset
ChIP HUES-8 GSE109524.NANOG.HUES-8 291 bp overlap
Neurod2 1 dataset
Motif ES_0h ES_0h-Neurod2_MA1993.2 6 bp overlap
Olig2 1 dataset
Motif ES_0h ES_0h-Olig2_MA1997.2 6 bp overlap
PAX1 1 dataset
Motif DE_12h DE_12h-PAX1_MA0779.2 16 bp overlap
PAX9 1 dataset
Motif DE_12h DE_12h-PAX9_MA0781.2 16 bp overlap
PGR 1 dataset
ChIP MCF-7_PROG GSE68355.PGR.MCF-7_PROG 254 bp overlap
PHF19 1 dataset
ChIP DU145_SH4 GSE135623.PHF19.DU145_SH4 297 bp overlap
PKNOX1 1 dataset
Motif ES_0h ES_0h-PKNOX1_MA0782.3 10 bp overlap
PKNOX2 1 dataset
Motif ES_0h ES_0h-PKNOX2_MA0783.1 12 bp overlap
PLAG1 1 dataset
ChIP K-562 GSE111469.PLAG1.K-562 289 bp overlap
POLR2A 3 datasets
ChIP body of pancreas ENCFF727UBE 339 bp overlap
ChIP stomach ENCFF607ZPU 295 bp overlap
ChIP thyroid gland ENCFF979LRR 193 bp overlap
POU2F1 3 datasets
ChIP 22Rv1_Veh GSE123565.POU2F1.22Rv1_Veh 352 bp overlap
ChIP T-47D GSE148277.POU2F1.T-47D 245 bp overlap
ChIP T-47D_D538G GSE148277.POU2F1.T-47D_D538G 279 bp overlap
POU2F3 1 dataset
ChIP NCI-H1048 GSE115123.POU2F3.NCI-H1048 205 bp overlap
POU5F1 3 datasets
ChIP HUES-8 GSE109524.POU5F1.HUES-8 492 bp overlap
ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 245 bp overlap
ChIP hiPSC GSE56567.POU5F1.hiPSC 272 bp overlap
PRDM10 1 dataset
ChIP Hep-G2 ENCSR289PSX.PRDM10.Hep-G2 151 bp overlap
PSIP1 1 dataset
ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 175 bp overlap
Prdm15 1 dataset
Motif ES_0h ES_0h-Prdm15_MA1616.2 11 bp overlap
RAD51 7 datasets
ChIP GM12878 ENCSR482TWQ.RAD51.GM12878 295 bp overlap
ChIP Hep-G2 ENCSR081WLS.RAD51.Hep-G2 232 bp overlap
ChIP HepG2 ENCFF188FEZ 354 bp overlap
ChIP K-562 ENCSR524BUE.RAD51.K-562 376 bp overlap
ChIP K562 ENCFF133ELP 371 bp overlap
ChIP MCF-7 ENCFF128SEB 364 bp overlap
ChIP MCF-7 ENCSR442VBJ.RAD51.MCF-7 360 bp overlap
RBBP5 1 dataset
ChIP WA01 ENCSR000AQC.RBBP5.WA01 492 bp overlap
RCOR1 1 dataset
ChIP keratinocyte_diff GSE57702.RCOR1.keratinocyte_diff 196 bp overlap
SIX2 1 dataset
Motif ES_0h ES_0h-SIX2_MA1119.2 11 bp overlap
SMARCA4 1 dataset
ChIP MCF-7 GSE123284.SMARCA4.MCF-7 398 bp overlap
SMARCB1 4 datasets
ChIP MCF-7 GSE123284.SMARCB1.MCF-7 288 bp overlap
ChIP MCF-7_4-hydroxytamoxifen GSE123284.SMARCB1.MCF-7_4-hydroxytamoxifen 385 bp overlap
ChIP MCF-7_DCDT GSE123284.SMARCB1.MCF-7_DCDT 363 bp overlap
ChIP MCF-7_Fulvestrant GSE123284.SMARCB1.MCF-7_Fulvestrant 455 bp overlap
SOX2 1 dataset
ChIP hiPSC GSE56567.SOX2.hiPSC 178 bp overlap
SP1 2 datasets
ChIP H1 ENCFF263FUH 321 bp overlap
ChIP WA01 ENCSR000BIR.SP1.WA01 244 bp overlap
SREBF1 1 dataset
Motif ES_0h ES_0h-SREBF1_MA0829.3 10 bp overlap
STAT3 1 dataset
ChIP MDA-MB-361 GSE152203.STAT3.MDA-MB-361 479 bp overlap
Stat2 1 dataset
Motif ES_0h ES_0h-Stat2_MA1623.2 10 bp overlap
TAF1 1 dataset
ChIP WA01 ENCSR000BHO.TAF1.WA01 285 bp overlap
TBX1 1 dataset
Motif ES_0h ES_0h-TBX1_MA0805.1 8 bp overlap
TBX15 1 dataset
Motif ES_0h ES_0h-TBX15_MA0803.1 8 bp overlap
TBX18 1 dataset
Motif ES_0h ES_0h-TBX18_MA1565.2 9 bp overlap
TBX2 1 dataset
Motif ES_0h ES_0h-TBX2_MA0688.2 9 bp overlap
TBX3 1 dataset
Motif ES_0h ES_0h-TBX3_MA1566.3 9 bp overlap
TBX4 1 dataset
Motif ES_0h ES_0h-TBX4_MA0806.1 8 bp overlap
TBX5 1 dataset
Motif ES_0h ES_0h-TBX5_MA0807.1 8 bp overlap
TCF3 1 dataset
ChIP NPC GSE154479.TCF3.NPC 224 bp overlap
TFAP4 1 dataset
Motif ES_0h ES_0h-TFAP4_MA0691.1 10 bp overlap
TFE3 2 datasets
ChIP Hep-G2 ENCSR589SNT.TFE3.Hep-G2 163 bp overlap
ChIP K562 ENCFF697ABG 194 bp overlap
TGIF1 1 dataset
Motif ES_0h ES_0h-TGIF1_MA0796.1 12 bp overlap
TGIF2 1 dataset
Motif ES_0h ES_0h-TGIF2_MA0797.1 12 bp overlap
TGIF2LX 1 dataset
Motif ES_0h ES_0h-TGIF2LX_MA1571.1 12 bp overlap
TGIF2LY 1 dataset
Motif ES_0h ES_0h-TGIF2LY_MA1572.1 12 bp overlap
TOE1 2 datasets
ChIP K562 ENCFF728FRA 209 bp overlap
ChIP MCF-7 ENCFF544WQF 252 bp overlap
TP53 11 datasets
ChIP GM06170 GSE55727.TP53.GM06170 210 bp overlap
ChIP H9 GSE142050.TP53.H9 425 bp overlap
ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 481 bp overlap
ChIP H9_ectoderm_IFI16 GSE142050.TP53.H9_ectoderm_IFI16 180 bp overlap
ChIP MCF-7_7-5h_IR_10Gy_Nutlin GSE100099.TP53.MCF-7_7-5h_IR_10Gy_Nutlin 386 bp overlap
ChIP MCF-7_nutlin GSE86164.TP53.MCF-7_nutlin 460 bp overlap
ChIP hESC_DAMAGED GSE39912.TP53.hESC_DAMAGED 373 bp overlap
ChIP hESC_DIFF GSE39912.TP53.hESC_DIFF 404 bp overlap
ChIP keratinocyte GSE56674.TP53.keratinocyte 192 bp overlap
ChIP keratinocyte_ADRIA GSE56674.TP53.keratinocyte_ADRIA 156 bp overlap
ChIP keratinocyte_CISP GSE56674.TP53.keratinocyte_CISP 379 bp overlap
TP63 7 datasets
ChIP keratinocyte GSE56674.TP63.keratinocyte 191 bp overlap
ChIP keratinocyte_CISP GSE56674.TP63.keratinocyte_CISP 210 bp overlap
ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 292 bp overlap
ChIP keratinocyte_D2 GSE59824.TP63.keratinocyte_D2 307 bp overlap
ChIP keratinocyte_D4 GSE59824.TP63.keratinocyte_D4 267 bp overlap
ChIP keratinocyte_D7 GSE59824.TP63.keratinocyte_D7 251 bp overlap
ChIP keratinocyte_epidermal GSE67382.TP63.keratinocyte_epidermal 319 bp overlap
TRIM28 1 dataset
ChIP hESC GSE115387.TRIM28.hESC 252 bp overlap
Tcf12 1 dataset
Motif ES_0h ES_0h-Tcf12_MA0521.3 6 bp overlap
Twist2 1 dataset
Motif ES_0h ES_0h-Twist2_MA0633.3 6 bp overlap
USF1 14 datasets
ChIP H1 ENCFF090WVU 188 bp overlap
ChIP HCT-116 ENCSR000BVK.USF1.HCT-116 305 bp overlap
ChIP HCT116 ENCFF330PYP 350 bp overlap
ChIP Hep-G2 ENCSR000BGM.USF1.Hep-G2 237 bp overlap
ChIP HepG2 ENCFF201JKA 182 bp overlap
ChIP HepG2 ENCFF807KYJ 201 bp overlap
ChIP Ishikawa ENCFF728IEG 104 bp overlap
ChIP Ishikawa ENCSR000BSX.USF1.Ishikawa 293 bp overlap
ChIP K-562 ENCSR000BKT.USF1.K-562 271 bp overlap
ChIP K562 ENCFF633EZB 265 bp overlap
ChIP SK-N-SH ENCSR000BMF.USF1.SK-N-SH 281 bp overlap
ChIP SK-N-SH ENCSR000BTZ.USF1.SK-N-SH 115 bp overlap
ChIP WA01 ENCSR000BIU.USF1.WA01 466 bp overlap
ChIP WTC11 ENCFF699QGS 406 bp overlap
USF2 9 datasets
ChIP A549 ENCFF343KII 333 bp overlap
ChIP GM12878 GSE97661.USF2.GM12878 224 bp overlap
ChIP Hep-G2 GSE97661.USF2.Hep-G2 295 bp overlap
ChIP IMR-90 ENCFF438KUN 257 bp overlap
ChIP IMR-90 ENCSR513UQG.USF2.IMR-90 266 bp overlap
ChIP K-562 ENCSR359NFW.USF2.K-562 256 bp overlap
ChIP K-562 ENCSR578KEN.USF2.K-562 161 bp overlap
ChIP K562 ENCFF306QPU 419 bp overlap
ChIP WTC11 ENCFF139JAW 229 bp overlap
ZBTB24 1 dataset
ChIP HCT-116 GSE111683.ZBTB24.HCT-116 169 bp overlap
ZBTB7B 1 dataset
ChIP Hep-G2 ENCSR322ULL.ZBTB7B.Hep-G2 161 bp overlap
ZEB1 1 dataset
Motif ES_0h ES_0h-ZEB1_MA0103.4 6 bp overlap
ZFX 1 dataset
ChIP C4-2B ENCFF652WZM 491 bp overlap
ZGPAT 1 dataset
ChIP Hep-G2 ENCSR704IGU.ZGPAT.Hep-G2 293 bp overlap
ZIM3 1 dataset
Motif ES_0h ES_0h-ZIM3_MA1709.2 11 bp overlap
ZNF184 1 dataset
Motif DE_12h DE_12h-ZNF184_MA2120.1 13 bp overlap
ZNF507 1 dataset
ChIP MCF-7 ENCFF080XWY 377 bp overlap
ZNF677 1 dataset
Motif DE_12h DE_12h-ZNF677_MA2101.1 12 bp overlap
ZNF687 1 dataset
ChIP MCF-7 ENCSR899BKM.ZNF687.MCF-7 238 bp overlap
ZNF85 1 dataset
Motif ES_0h ES_0h-ZNF85_MA1720.2 12 bp overlap
Zfp335 1 dataset
Motif DE_12h DE_12h-Zfp335_MA2002.2 7 bp overlap
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