Enables methylated histone binding activity. Involved in negative regulation of gene expression, epigenetic. Located in ESC/E(Z) complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PHF19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHF19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHF19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:120,579,589–120,580,675 | 297.0 kb | Distal (>10kb) Multiome | 900 | |
| chr9:120,713,676–120,715,795 | 162.6 kb | Distal (>10kb) Multiome | 761 | |
| chr9:120,730,681–120,731,453 | 146.2 kb | Distal (>10kb) Multiome | 456 | |
| chr9:120,792,955–120,793,917 | 83.8 kb | Distal (>10kb) Multiome | 991 | |
| chr9:120,842,458–120,843,456 | 34.2 kb | Distal (>10kb) Multiome | 838 | |
| chr9:120,868,216–120,869,551 | 8.3 kb | Proximal (<10kb) Multiome | 643 | |
| chr9:120,873,261–120,874,043 | 3.6 kb | Proximal (<10kb) Multiome | 247 | |
| chr9:120,875,854–120,877,760 | 903 bp | At TSS Multiome | 982 | |
| chr9:120,928,372–120,929,413 | 51.8 kb | Distal (>10kb) Multiome HiCAR | 626 | |
| chr9:121,074,349–121,075,511 | 197.8 kb | Distal (>10kb) Multiome | 1041 | |
| chr9:121,121,551–121,122,082 | 244.6 kb | Distal (>10kb) Multiome | 539 |
Genomic view of the PHF19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.