GRHL1

grainyhead like transcription factor 1 | LBP-32, MGR, TFCP2L2

This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]

Biological processes 32 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)chromatin DNA binding (GO:0031490)epidermis development (GO:0008544)epidermis development (GO:0008544)identical protein binding (GO:0042802)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating GRHL1 0 TFs

Transcription factors with Perturb-seq knockdown data for GRHL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRHL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GRHL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRHL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:9,770,260–9,771,096	181.1 kb	Distal (>10kb) Multiome	321
chr2:9,813,714–9,814,312	137.6 kb	Distal (>10kb) Multiome	406
chr2:9,843,034–9,844,039	108.2 kb	Distal (>10kb) Multiome	965
chr2:9,950,478–9,952,371	123 bp	At TSS Multiome	704
chr2:10,042,279–10,044,590	92.4 kb	Distal (>10kb) Multiome	999
chr2:10,057,234–10,058,147	106.0 kb	Distal (>10kb) Multiome	504
chr2:10,079,477–10,080,916	128.4 kb	Distal (>10kb) Multiome	381
chr2:10,097,234–10,097,850	145.9 kb	Distal (>10kb) Multiome	372
chr2:10,120,050–10,120,940	168.7 kb	Distal (>10kb) Multiome	1054
chr2:10,121,967–10,123,307	170.9 kb	Distal (>10kb) Multiome	958

Genome Browser

Genomic view of the GRHL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.