DPF1

double PHD fingers 1 | BAF45b, NEUD4, SMARCG1, neuro-d4

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in nervous system development. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of nBAF complex. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC5

Biological processes 22 terms

apoptotic process (GO:0006915)chromatin (GO:0000785)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)nBAF complex (GO:0071565)nBAF complex (GO:0071565)nervous system development (GO:0007399)nervous system development (GO:0007399)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of cell differentiation (GO:0045597)positive regulation of double-strand break repair (GO:2000781)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of G0 to G1 transition (GO:0070316)regulation of G1/S transition of mitotic cell cycle (GO:2000045)regulation of mitotic metaphase/anaphase transition (GO:0030071)regulation of nucleotide-excision repair (GO:2000819)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)sequence-specific double-stranded DNA binding (GO:1990837)transcription coregulator activity (GO:0003712)

Expression (TPM)

TFs regulating DPF1 0 TFs

Transcription factors with Perturb-seq knockdown data for DPF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DPF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:37,906,047–37,907,698	322.8 kb	Distal (>10kb) Multiome HiCAR	915
chr19:38,004,389–38,004,823	224.9 kb	Distal (>10kb) Multiome	367
chr19:38,183,265–38,183,970	46.0 kb	Distal (>10kb) Multiome	156
chr19:38,223,967–38,224,571	5.3 kb	Proximal (<10kb) Multiome	677
chr19:38,229,570–38,230,021	122 bp	At TSS Multiome	354
chr19:38,233,894–38,234,121	9.7 kb	Proximal (<10kb)	287
chr19:38,255,918–38,256,778	26.9 kb	Distal (>10kb) Multiome	371
chr19:38,263,873–38,265,423	34.8 kb	Distal (>10kb) Multiome	590
chr19:38,304,071–38,305,583	75.5 kb	Distal (>10kb) Multiome	531
chr19:38,315,514–38,316,642	86.4 kb	Distal (>10kb) Multiome	747
chr19:38,319,279–38,320,342	90.3 kb	Distal (>10kb) Multiome	359
chr19:38,335,358–38,337,514	106.1 kb	Distal (>10kb) Multiome	898
chr19:38,361,454–38,362,809	132.5 kb	Distal (>10kb) Multiome	604
chr19:38,374,176–38,375,269	145.0 kb	Distal (>10kb) Multiome	1041
chr19:38,385,485–38,386,937	156.3 kb	Distal (>10kb) Multiome	156
chr19:38,387,065–38,389,471	158.4 kb	Distal (>10kb) Multiome	591
chr19:38,394,369–38,395,035	165.0 kb	Distal (>10kb) Multiome	191
chr19:38,402,504–38,403,738	173.4 kb	Distal (>10kb) Multiome	940
chr19:38,417,766–38,418,568	188.5 kb	Distal (>10kb) Multiome	407
chr19:38,434,539–38,435,128	205.2 kb	Distal (>10kb) Multiome	238
chr19:38,452,620–38,453,510	223.5 kb	Distal (>10kb) Multiome	355
chr19:38,506,710–38,507,745	277.6 kb	Distal (>10kb) Multiome	369
chr19:38,514,956–38,515,568	285.6 kb	Distal (>10kb) Multiome	404

Genome Browser

Genomic view of the DPF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.