Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF507. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF507 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF507, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:30,584,020–30,584,654 | 1761.3 kb | Distal (>10kb) Multiome HiCAR | 70 | |
| chr19:31,348,590–31,352,149 | 996.1 kb | Distal (>10kb) Multiome HiCAR | 483 | |
| chr19:32,340,137–32,340,568 | 5.1 kb | Proximal (<10kb) | 171 | |
| chr19:32,341,758–32,342,555 | 3.1 kb | Proximal (<10kb) | 26 | |
| chr19:32,345,298–32,346,342 | 35 bp | At TSS Multiome | 791 | |
| chr19:32,403,163–32,403,921 | 57.9 kb | Distal (>10kb) Multiome | 151 | |
| chr19:32,405,092–32,406,553 | 60.2 kb | Distal (>10kb) Multiome | 914 | |
| chr19:32,580,669–32,581,896 | 235.5 kb | Distal (>10kb) Multiome | 774 |
Genomic view of the ZNF507 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.