This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for PAX9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAX9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAX9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:36,646,734–36,648,858 | 8.8 kb | Proximal (<10kb) | 499 | |
| chr14:36,653,000–36,653,259 | 4.4 kb | Proximal (<10kb) | 70 | |
| chr14:36,655,705–36,656,663 | 1.0 kb | Proximal (<10kb) | 313 | |
| chr14:36,657,526–36,658,352 | at TSS | At TSS | 107 | |
| chr14:36,658,495–36,659,134 | 825 bp | At TSS | 113 | |
| chr14:36,660,899–36,662,390 | 3.2 kb | Proximal (<10kb) | 408 | |
| chr14:36,662,473–36,663,979 | 4.8 kb | Proximal (<10kb) | 279 | |
| chr14:36,666,238–36,667,190 | 8.6 kb | Proximal (<10kb) | 185 |
Genomic view of the PAX9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.