This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KRAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:24,953,929–24,954,769 | 296.5 kb | Distal (>10kb) Multiome | 128 | |
| chr12:24,963,126–24,963,906 | 287.4 kb | Distal (>10kb) Multiome | 70 | |
| chr12:25,194,832–25,195,643 | 55.7 kb | Distal (>10kb) Multiome | 778 | |
| chr12:25,249,926–25,251,797 | 199 bp | At TSS Multiome | 848 | |
| chr12:25,256,800–25,257,292 | 5.9 kb | Proximal (<10kb) | 97 | |
| chr12:25,384,448–25,387,046 | 135.3 kb | Distal (>10kb) Multiome HiCAR | 1039 | |
| chr12:25,396,937–25,397,449 | 146.2 kb | Distal (>10kb) Multiome | 117 | |
| chr12:25,491,400–25,492,151 | 240.8 kb | Distal (>10kb) Multiome | 132 |
Genomic view of the KRAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.