chr10:72,456,009–72,456,568

chr10 : 72,456,009 – 72,456,568

559 bp 83 TFs 6 linked genes

This 559 bp open chromatin element is linked to 6 target genes and is bound by 83 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
DNAJB12		101.4 kb	Distal	Multiome
MICU1		169.7 kb	Distal	Multiome
DDIT4		182.4 kb	Distal	Multiome
MCU		235.8 kb	Distal	Multiome
ASCC1		240.1 kb	Distal	Multiome
ANAPC16		240.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

83 transcription factors

ChIP THP-1_R1881 GSE131381.AR.THP-1_R1881 513 bp overlap

ARID1B 1 dataset

ChIP K-562 ENCSR822CCM.ARID1B.K-562 217 bp overlap

ASCL1 1 dataset

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 188 bp overlap

BRD2 2 datasets

ChIP THP-1_DMSO GSE138084.BRD2.THP-1_DMSO 177 bp overlap

ChIP THP-1_iBET-BD2 GSE138084.BRD2.THP-1_iBET-BD2 198 bp overlap

BRD3 6 datasets

ChIP MV4-11_DMSO GSE120715.BRD3.MV4-11_DMSO 394 bp overlap

ChIP MV4-11_IBET151_500nM GSE120715.BRD3.MV4-11_IBET151_500nM 332 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD3.MV4-11_IBET151_50nM 268 bp overlap

ChIP THP-1_DMSO GSE138084.BRD3.THP-1_DMSO 551 bp overlap

ChIP THP-1_DMSO-PMA GSE138084.BRD3.THP-1_DMSO-PMA 176 bp overlap

ChIP THP-1_iBET-BD2 GSE138084.BRD3.THP-1_iBET-BD2 244 bp overlap

BRD4 13 datasets

ChIP K-562_dilution-6-100 GSE140325.BRD4.K-562_dilution-6-100 80 bp overlap

ChIP MOLM-14_CA25 GSE65138.BRD4.MOLM-14_CA25 488 bp overlap

ChIP MOLM-14_DMSO GSE65138.BRD4.MOLM-14_DMSO 559 bp overlap

ChIP MV4-11-B_BI00894999_100nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_100nM_4h 206 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD4.MV4-11_DMSO 415 bp overlap

ChIP MV4-11_IBET GSE71776.BRD4.MV4-11_IBET 186 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD4.MV4-11_IBET151_50nM 151 bp overlap

ChIP MV4-11_SGC GSE71776.BRD4.MV4-11_SGC 559 bp overlap

ChIP THP-1_DMSO GSE138084.BRD4.THP-1_DMSO 559 bp overlap

ChIP THP-1_iBET-BD1-PMA GSE138084.BRD4.THP-1_iBET-BD1-PMA 194 bp overlap

ChIP THP-1_iBET-BD2 GSE138084.BRD4.THP-1_iBET-BD2 559 bp overlap

ChIP THP-1_iBET-BD2-PMA GSE138084.BRD4.THP-1_iBET-BD2-PMA 235 bp overlap

ChIP THP-1_iBET-BD2-PMA GSE138084.BRD4.THP-1_iBET-BD2-PMA 102 bp overlap

ChIP MOLM-14_IBET GSE65138.CDK8.MOLM-14_IBET 173 bp overlap

CEBPA 7 datasets

ChIP Kasumi-1_CEBPA-ER_E2 GSE102697.CEBPA.Kasumi-1_CEBPA-ER_E2 282 bp overlap

ChIP THP-1_1-25D_24h GSE124032.CEBPA.THP-1_1-25D_24h 99 bp overlap

ChIP THP-1_1-25D_24h GSE124032.CEBPA.THP-1_1-25D_24h 216 bp overlap

ChIP THP-1_1-25D_8h GSE124032.CEBPA.THP-1_1-25D_8h 285 bp overlap

ChIP THP-1_EtOH_24h GSE124032.CEBPA.THP-1_EtOH_24h 116 bp overlap

ChIP THP-1_EtOH_2h GSE124032.CEBPA.THP-1_EtOH_2h 223 bp overlap

ChIP THP-1_EtOH_8h GSE124032.CEBPA.THP-1_EtOH_8h 313 bp overlap

CEBPB 5 datasets

ChIP HL-60_CEBPB_overexpressed GSE100486.CEBPB.HL-60_CEBPB_overexpressed 101 bp overlap

ChIP K562 ENCFF584CTB 525 bp overlap

ChIP MV4-11 GSE88746.CEBPB.MV4-11 258 bp overlap

ChIP THP-1_eGFP-Pam3csk-4h GSE103477.CEBPB.THP-1_eGFP-Pam3csk-4h 171 bp overlap

ChIP monocyte_MACROPHAGE GSE31621.CEBPB.monocyte_MACROPHAGE 113 bp overlap

CTBP1 1 dataset

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 212 bp overlap

Cebpa 4 datasets

ChIP BLaER1 ENCFF093OYK 457 bp overlap

ChIP BLaER1 ENCFF274GAT 559 bp overlap

ChIP BLaER1 ENCFF364PUR 288 bp overlap

ChIP BLaER1 ENCFF844FIP 251 bp overlap

Motif DE_36h DE_36h-Crx_MA0467.3 6 bp overlap

Motif DE_36h DE_36h-DPRX_MA1480.2 9 bp overlap

Dmbx1 1 dataset

Motif DE_36h DE_36h-Dmbx1_MA0883.2 10 bp overlap

EGR1 7 datasets

ChIP HL-60_PMA GSE106359.EGR1.HL-60_PMA 167 bp overlap

ChIP K-562 ENCSR000BNE.EGR1.K-562 117 bp overlap

ChIP K562 ENCFF006PJY 210 bp overlap

ChIP K562 ENCFF895KGN 204 bp overlap

ChIP fibroblast_DOX-CLOB-24h GSE134924.EGR1.fibroblast_DOX-CLOB-24h 320 bp overlap

ChIP macrophage_D3 GSE136216.EGR1.macrophage_D3 247 bp overlap

ChIP macrophage_D4 GSE136216.EGR1.macrophage_D4 233 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 404 bp overlap

EP300 2 datasets

ChIP AML GSE131939.EP300.AML 138 bp overlap

ChIP AML_shaml1-eto GSE131939.EP300.AML_shaml1-eto 185 bp overlap

ChIP pleural-effusion GSE86538.ESR1.pleural-effusion 113 bp overlap

ChIP SKH1_10d GSE87283.EVI1.SKH1_10d 208 bp overlap

ChIP ProEs GSE59087.EZH1.ProEs 91 bp overlap

ChIP NB4 GSE23730.FLI1.NB4 157 bp overlap

FOSL1 2 datasets

ChIP K-562 ENCSR239ZLZ.FOSL1.K-562 246 bp overlap

ChIP K562 ENCFF455MKD 469 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 498 bp overlap

ChIP DE DE-FOXA2-2 459 bp overlap

GATA2 1 dataset

ChIP TF1 GSE73207.GATA2.TF1 401 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 506 bp overlap

ChIP DE DE-GATA4-2 554 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 559 bp overlap

ChIP DE DE-GATA6-2 559 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 515 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 552 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 380 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 549 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 559 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 559 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 547 bp overlap

Motif DE_36h DE_36h-GSC_MA0648.2 6 bp overlap

Motif DE_36h DE_36h-GSC2_MA0891.2 6 bp overlap

HDAC1 1 dataset

ChIP NB4 GSE126720.HDAC1.NB4 214 bp overlap

ChIP Hep-G2 ENCSR528PSI.HLF.Hep-G2 166 bp overlap

ChIP HepG2 ENCFF854JLR 245 bp overlap

HNF4A 1 dataset

ChIP Caco-2_DIFF GSE23436.HNF4A.Caco-2_DIFF 104 bp overlap

IKZF1 3 datasets

ChIP K-562 ENCSR395HWC.IKZF1.K-562 462 bp overlap

ChIP K562 ENCFF348IBL 170 bp overlap

ChIP K562 ENCFF771OHZ 121 bp overlap

ChIP K-562 GSE103215.ILF3.K-562 433 bp overlap

ChIP monocyte_nopretreatment GSE100381.IRF1.monocyte_nopretreatment 104 bp overlap

JMJD1C 1 dataset

ChIP NB4 GSE63484.JMJD1C.NB4 212 bp overlap

ChIP K-562 ENCSR000EGN.JUND.K-562 140 bp overlap

KDM1A 1 dataset

ChIP NB4_DMSO GSE128528.KDM1A.NB4_DMSO 520 bp overlap

KLF16 1 dataset

ChIP K-562 ENCSR760UVO.KLF16.K-562 100 bp overlap

KMT2A 2 datasets

ChIP MV4-11 GSE79899.KMT2A.MV4-11 207 bp overlap

ChIP THP-1 GSE79899.KMT2A.THP-1 101 bp overlap

KMT2B 1 dataset

ChIP AML_OG86 GSE112074.KMT2B.AML_OG86 247 bp overlap

ChIP K-562 ENCSR000EGI.MAFF.K-562 121 bp overlap

ChIP K-562 ENCSR000EFV.MAX.K-562 169 bp overlap

ChIP NB4 ENCFF966MWB 250 bp overlap

ChIP NB4 ENCFF966MWB 199 bp overlap

MECOM 1 dataset

ChIP SKH1_E2 GSE102697.MECOM.SKH1_E2 60 bp overlap

MEIS1 1 dataset

ChIP CHRF28811 ERR063469.MEIS1.CHRF28811 445 bp overlap

ChIP melanocyte_CTR GSE50681.MITF.melanocyte_CTR 291 bp overlap

ChIP THP-1 GSE90769.MYB.THP-1 207 bp overlap

ChIP NB4 ENCFF142PRP 271 bp overlap

NEUROD1 5 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 494 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 405 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 511 bp overlap

ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 340 bp overlap

ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 393 bp overlap

ChIP K-562 ENCSR000FCC.NFE2.K-562 140 bp overlap

Motif DE_36h DE_36h-OTX1_MA0711.2 6 bp overlap

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 238 bp overlap

ChIP K562 ENCFF286KMN 265 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 173 bp overlap

PITX1 1 dataset

Motif DE_36h DE_36h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_36h DE_36h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_36h DE_36h-PITX3_MA0714.2 6 bp overlap

RAD21 2 datasets

ChIP HAP1 GSE152721.RAD21.HAP1 415 bp overlap

ChIP THP-1_Pam3csk-150m-Flavo-030m GSE103477.RAD21.THP-1_Pam3csk-150m-Flavo-030m 345 bp overlap

RHOXF1 1 dataset

Motif DE_36h DE_36h-RHOXF1_MA0719.2 6 bp overlap

RUNX1 3 datasets

ChIP CD34_ADULT GSE70660.RUNX1.CD34_ADULT 265 bp overlap

ChIP MV4-11 GSE79899.RUNX1.MV4-11 310 bp overlap

ChIP NB4 GSE81992.RUNX1.NB4 368 bp overlap

SMAD2-3 4 datasets

ChIP HGrC1_EV GSE138496.SMAD2-3.HGrC1_EV 114 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 481 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 559 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 454 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 388 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 531 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 307 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 549 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 559 bp overlap

SMARCA4 1 dataset

ChIP K562 ENCFF506JCB 292 bp overlap

SMARCC1 1 dataset

ChIP G-401_Dox GSE71504.SMARCC1.G-401_Dox 195 bp overlap

SMARCE1 1 dataset

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 235 bp overlap

SMC1A 1 dataset

ChIP monocyte_INFg GSE98367.SMC1A.monocyte_INFg 559 bp overlap

SNAI2 1 dataset

ChIP SMS-CTR_D48 GSE137168.SNAI2.SMS-CTR_D48 178 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 288 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 391 bp overlap

SPI1 18 datasets

ChIP CD34_FETAL GSE70660.SPI1.CD34_FETAL 189 bp overlap

ChIP CTV-1_delQ GSE128835.SPI1.CTV-1_delQ 172 bp overlap

ChIP DC_96h_donorM GSE128834.SPI1.DC_96h_donorM 145 bp overlap

ChIP EM-3 GSE128834.SPI1.EM-3 158 bp overlap

ChIP HL-60 ENCFF645GBT 189 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 221 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 126 bp overlap

ChIP Kasumi-1_SICTR GSE60130.SPI1.Kasumi-1_SICTR 158 bp overlap

ChIP Kasumi-1_SIRUNX1ETO GSE60130.SPI1.Kasumi-1_SIRUNX1ETO 212 bp overlap

ChIP NB4 GSE128834.SPI1.NB4 266 bp overlap

ChIP THP-1 GSE128834.SPI1.THP-1 138 bp overlap

ChIP U-937 GSE128834.SPI1.U-937 199 bp overlap

ChIP macrophage_D7_donorP GSE128834.SPI1.macrophage_D7_donorP 209 bp overlap

ChIP monocyte GSE31621.SPI1.monocyte 143 bp overlap

ChIP monocyte_MACROPHAGE GSE31621.SPI1.monocyte_MACROPHAGE 157 bp overlap

ChIP primary-monocyte_18h_donorO GSE128834.SPI1.primary-monocyte_18h_donorO 197 bp overlap

ChIP primary-monocyte_4h_donorO GSE128834.SPI1.primary-monocyte_4h_donorO 150 bp overlap

ChIP primary-neutrophil_donorF GSE128834.SPI1.primary-neutrophil_donorF 106 bp overlap

ChIP OCI-Ly3_SHCTR GSE56857.SPIB.OCI-Ly3_SHCTR 179 bp overlap

STAG2 1 dataset

ChIP OCI-AML-3 GSE111537.STAG2.OCI-AML-3 364 bp overlap

STAT3 2 datasets

ChIP T-47D_JC5056 GSE126004.STAT3.T-47D_JC5056 229 bp overlap

ChIP monocyte_IL10 GSE120943.STAT3.monocyte_IL10 133 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 389 bp overlap

TEAD4 1 dataset

ChIP MDA-MB-231 GSE66081.TEAD4.MDA-MB-231 197 bp overlap

TERF1 1 dataset

ChIP LCL GSE55053.TERF1.LCL 117 bp overlap

TFAP2A 1 dataset

Motif DE_36h DE_36h-TFAP2A_MA0003.5 9 bp overlap

TFAP2C 1 dataset

Motif DE_36h DE_36h-TFAP2C_MA0814.3 9 bp overlap

ChIP LNCaP_DHT GSE63202.TOP1.LNCaP_DHT 297 bp overlap

ChIP THP-1_1d_1-25-OH-2D3 GSE89431.VDR.THP-1_1d_1-25-OH-2D3 147 bp overlap

ZBTB17 2 datasets

ChIP HEK293 ENCFF865LIO 330 bp overlap

ChIP K562 ENCFF731UTU 441 bp overlap

ZBTB6 1 dataset

ChIP HEK293 GSE76494.ZBTB6.HEK293 181 bp overlap

ZNF143 2 datasets

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 67 bp overlap

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 279 bp overlap

ZNF317 1 dataset

ChIP HEK293 GSE76494.ZNF317.HEK293 284 bp overlap