Enables calcium channel activity; identical protein binding activity; and uniporter activity. Involved in several processes, including cellular response to calcium ion starvation; positive regulation of mitochondrial calcium ion concentration; and positive regulation of mitochondrial fission. Located in mitochondrion. Part of uniplex complex. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MCU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:72,364,187–72,364,837 | 327.7 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr10:72,365,363–72,366,008 | 326.4 kb | Distal (>10kb) Multiome HiCAR | 20 | |
| chr10:72,456,009–72,456,568 | 235.8 kb | Distal (>10kb) Multiome | 83 | |
| chr10:72,625,602–72,626,407 | 66.0 kb | Distal (>10kb) Multiome | 819 | |
| chr10:72,691,777–72,692,827 | 18 bp | At TSS Multiome | 676 | |
| chr10:72,759,040–72,759,484 | 67.2 kb | Distal (>10kb) Multiome | 35 |
Genomic view of the MCU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.