This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KMT2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KMT2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KMT2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,471,034–35,471,539 | 246.7 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,509,786–35,510,900 | 207.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 172.3 kb | Distal (>10kb) Multiome | 879 | |
| chr19:35,557,343–35,558,684 | 159.9 kb | Distal (>10kb) Multiome HiCAR | 452 | |
| chr19:35,612,546–35,613,176 | 105.3 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 89.1 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,641,602–35,642,192 | 76.2 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,643,064–35,645,730 | 74.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 69.8 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 44.6 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 15.5 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 236 bp | At TSS Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 22.9 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 27.3 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 30.5 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 40.1 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 50.0 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 57.5 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 66.8 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 143.3 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 150.5 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 152.0 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 181.7 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 213.7 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 218.4 kb | Distal (>10kb) Multiome | 417 | |
| chr19:35,986,945–35,987,622 | 269.3 kb | Distal (>10kb) Multiome | 363 | |
| chr19:35,994,796–35,995,940 | 277.2 kb | Distal (>10kb) Multiome | 897 | |
| chr19:36,008,519–36,009,006 | 290.8 kb | Distal (>10kb) Multiome | 427 | |
| chr19:36,013,972–36,014,810 | 296.4 kb | Distal (>10kb) Multiome | 623 |
Genomic view of the KMT2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.