This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for ASCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:71,963,568–71,965,093 | 251.8 kb | Distal (>10kb) Multiome | 614 | |
| chr10:72,048,540–72,049,027 | 167.5 kb | Distal (>10kb) Multiome | 552 | |
| chr10:72,215,518–72,216,511 | 166 bp | At TSS Multiome | 971 | |
| chr10:72,244,755–72,245,425 | 28.9 kb | Distal (>10kb) Multiome | 394 | |
| chr10:72,254,948–72,255,560 | 38.9 kb | Distal (>10kb) Multiome | 585 | |
| chr10:72,259,944–72,262,216 | 44.7 kb | Distal (>10kb) Multiome | 1074 | |
| chr10:72,272,463–72,275,209 | 57.5 kb | Distal (>10kb) Multiome | 1276 | |
| chr10:72,297,342–72,298,653 | 81.8 kb | Distal (>10kb) Multiome | 804 | |
| chr10:72,319,311–72,320,392 | 103.5 kb | Distal (>10kb) Multiome | 894 | |
| chr10:72,328,158–72,328,974 | 112.2 kb | Distal (>10kb) Multiome | 491 | |
| chr10:72,331,701–72,332,670 | 115.9 kb | Distal (>10kb) Multiome | 707 | |
| chr10:72,353,679–72,355,474 | 138.7 kb | Distal (>10kb) Multiome | 1081 | |
| chr10:72,364,187–72,364,837 | 148.2 kb | Distal (>10kb) Multiome | 539 | |
| chr10:72,365,363–72,366,008 | 149.5 kb | Distal (>10kb) Multiome | 20 | |
| chr10:72,456,009–72,456,568 | 240.1 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the ASCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.