DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for DNAJB12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJB12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJB12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:72,215,518–72,216,511 | 138.8 kb | Distal (>10kb) Multiome | 971 | |
| chr10:72,244,755–72,245,425 | 109.8 kb | Distal (>10kb) Multiome | 394 | |
| chr10:72,254,948–72,255,560 | 99.7 kb | Distal (>10kb) Multiome | 585 | |
| chr10:72,259,944–72,262,216 | 93.9 kb | Distal (>10kb) Multiome | 1074 | |
| chr10:72,272,463–72,275,209 | 81.1 kb | Distal (>10kb) Multiome | 1276 | |
| chr10:72,297,342–72,298,653 | 56.8 kb | Distal (>10kb) Multiome | 804 | |
| chr10:72,319,311–72,320,392 | 35.1 kb | Distal (>10kb) Multiome | 894 | |
| chr10:72,328,158–72,328,974 | 26.5 kb | Distal (>10kb) Multiome | 491 | |
| chr10:72,331,701–72,332,670 | 22.8 kb | Distal (>10kb) Multiome | 707 | |
| chr10:72,353,679–72,355,474 | 18 bp | At TSS Multiome | 1081 | |
| chr10:72,364,187–72,364,837 | 9.5 kb | Proximal (<10kb) Multiome | 539 | |
| chr10:72,365,363–72,366,008 | 10.8 kb | Distal (>10kb) Multiome | 20 | |
| chr10:72,456,009–72,456,568 | 101.4 kb | Distal (>10kb) Multiome | 83 | |
| chr10:72,625,602–72,626,407 | 271.2 kb | Distal (>10kb) Multiome HiCAR | 819 |
Genomic view of the DNAJB12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.