chr20 : 25,857,954 25,858,847
893 bp 97 TFs 1 linked gene
This 893 bp open chromatin element is linked to FAM182B and is bound by 97 transcription factors.
Linked Genes
1 gene
Gene Expression Dist. to TSS Distance Link type
FAM182B 1.1 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr20:25,852,954 – 25,863,847
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
97 transcription factors
Source
Cell type
AGO1 3 datasets
ChIP Hep-G2 ENCSR555ZMV.AGO1.Hep-G2 315 bp overlap
ChIP Hep-G2 GSE120104.AGO1.Hep-G2 253 bp overlap
ChIP HepG2 ENCFF358CXO 701 bp overlap
AGO2 3 datasets
ChIP HepG2 ENCFF252VFI 503 bp overlap
ChIP HepG2 ENCFF773YDL 503 bp overlap
ChIP HepG2 ENCFF773YDL 665 bp overlap
AR 4 datasets
ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 150 bp overlap
ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 139 bp overlap
ChIP MDA-MB-453_FOXA1 ERP003503.AR.MDA-MB-453_FOXA1 153 bp overlap
ChIP prostate_cancer-associated-fibroblasts GSE90772.AR.prostate_cancer-associated-fibroblasts 216 bp overlap
BCL6 1 dataset
ChIP CD4 GSE59933.BCL6.CD4 141 bp overlap
BCOR 4 datasets
ChIP B-cell_GERMINAL_CENTER GSE43350.BCOR.B-cell_GERMINAL_CENTER 239 bp overlap
ChIP B-cell_GERMINAL_CENTER GSE43350.BCOR.B-cell_GERMINAL_CENTER 69 bp overlap
ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 203 bp overlap
ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 381 bp overlap
BRD3 1 dataset
ChIP MM1-S GSE43743.BRD3.MM1-S 350 bp overlap
CBFB 1 dataset
ChIP ME-1 GSE46044.CBFB.ME-1 271 bp overlap
CDKN1B 1 dataset
ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 297 bp overlap
CREB1 2 datasets
ChIP A-549 ENCSR000BRB.CREB1.A-549 119 bp overlap
ChIP Hep-G2 ENCSR000BVL.CREB1.Hep-G2 195 bp overlap
CTCF 1 dataset
ChIP dorsolateral prefrontal cortex ENCFF433UFM 545 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF335XTP 345 bp overlap
E2F6 2 datasets
ChIP A-549 ENCSR000BTC.E2F6.A-549 153 bp overlap
ChIP WA01 ENCSR000BSI.E2F6.WA01 198 bp overlap
EGR1 1 dataset
ChIP Hep-G2 ENCSR026GSW.EGR1.Hep-G2 142 bp overlap
ERF::FIGLA 3 datasets
Motif DE_12h DE_12h-ERFFIGLA_MA1934.2 13 bp overlap
Motif DE_48h DE_48h-ERFFIGLA_MA1934.2 13 bp overlap
Motif DE_60h DE_60h-ERFFIGLA_MA1934.2 13 bp overlap
ERG 2 datasets
ChIP CD34_NR29 GSE23730.ERG.CD34_NR29 201 bp overlap
ChIP ME-1 GSE46044.ERG.ME-1 263 bp overlap
ESR1 1 dataset
ChIP Ishikawa_ETV4-KO1_Mili GSE129803.ESR1.Ishikawa_ETV4-KO1_Mili 254 bp overlap
ETV2::FIGLA 3 datasets
Motif DE_12h DE_12h-ETV2FIGLA_MA1941.2 13 bp overlap
Motif DE_48h DE_48h-ETV2FIGLA_MA1941.2 13 bp overlap
Motif DE_60h DE_60h-ETV2FIGLA_MA1941.2 13 bp overlap
ETV5::FIGLA 3 datasets
Motif DE_12h DE_12h-ETV5FIGLA_MA1945.2 14 bp overlap
Motif DE_48h DE_48h-ETV5FIGLA_MA1945.2 14 bp overlap
Motif DE_60h DE_60h-ETV5FIGLA_MA1945.2 14 bp overlap
EZH2 3 datasets
ChIP H1 ENCFF232NZA 760 bp overlap
ChIP H1 ENCFF232NZA 428 bp overlap
ChIP keratinocyte ENCFF070STK 526 bp overlap
Foxn1 6 datasets
Motif DE_12h DE_12h-Foxn1_MA1684.1 6 bp overlap
Motif DE_24h DE_24h-Foxn1_MA1684.1 6 bp overlap
Motif DE_36h DE_36h-Foxn1_MA1684.1 6 bp overlap
Motif DE_48h DE_48h-Foxn1_MA1684.1 6 bp overlap
Motif DE_60h DE_60h-Foxn1_MA1684.1 6 bp overlap
Motif DE_72h DE_72h-Foxn1_MA1684.1 6 bp overlap
GABPB1 1 dataset
ChIP HepG2 ENCFF315AWN 581 bp overlap
GATA6 1 dataset
ChIP PATU8988 GSE47535.GATA6.PATU8988 189 bp overlap
HEXIM1 1 dataset
ChIP HCT-116 GSE72622.HEXIM1.HCT-116 330 bp overlap
HNRNPC 1 dataset
ChIP Hep-G2 GSE120104.HNRNPC.Hep-G2 201 bp overlap
HNRNPL 5 datasets
ChIP Hep-G2 GSE120104.HNRNPL.Hep-G2 155 bp overlap
ChIP HepG2 ENCFF671UYF 323 bp overlap
ChIP HepG2 ENCFF671UYF 491 bp overlap
ChIP HepG2 ENCFF684GAM 323 bp overlap
ChIP HepG2 ENCFF684GAM 491 bp overlap
HNRNPLL 5 datasets
ChIP Hep-G2 ENCSR804HMZ.HNRNPLL.Hep-G2 212 bp overlap
ChIP Hep-G2 ENCSR804HMZ.HNRNPLL.Hep-G2 482 bp overlap
ChIP Hep-G2 GSE120104.HNRNPLL.Hep-G2 292 bp overlap
ChIP HepG2 ENCFF355PIC 151 bp overlap
ChIP HepG2 ENCFF952XAB 176 bp overlap
HOXA3 1 dataset
ChIP Hep-G2 ENCSR999JKC.HOXA3.Hep-G2 244 bp overlap
KDM4A 2 datasets
ChIP H1 ENCFF078LED 693 bp overlap
ChIP WA01 ENCSR000AVC.KDM4A.WA01 661 bp overlap
KDM5B 1 dataset
ChIP Hep-G2 ENCSR227MRE.KDM5B.Hep-G2 195 bp overlap
KMT2A 1 dataset
ChIP CCRF-CEM GSE83671.KMT2A.CCRF-CEM 224 bp overlap
LIN54 8 datasets
Motif DE_12h DE_12h-LIN54_MA0619.2 7 bp overlap
Motif DE_24h DE_24h-LIN54_MA0619.2 7 bp overlap
Motif DE_36h DE_36h-LIN54_MA0619.2 7 bp overlap
Motif DE_48h DE_48h-LIN54_MA0619.2 7 bp overlap
Motif DE_60h DE_60h-LIN54_MA0619.2 7 bp overlap
Motif DE_72h DE_72h-LIN54_MA0619.2 7 bp overlap
ChIP Hep-G2 ENCSR597MCV.LIN54.Hep-G2 265 bp overlap
ChIP HepG2 ENCFF662XDE 737 bp overlap
MAF1 1 dataset
ChIP THP-1_macrophage_PMA GSE96800.MAF1.THP-1_macrophage_PMA 163 bp overlap
MAX 9 datasets
ChIP A-549 ENCSR000BTJ.MAX.A-549 234 bp overlap
ChIP Hep-G2 ENCSR168DYA.MAX.Hep-G2 245 bp overlap
ChIP Hep-G2 ENCSR000BTM.MAX.Hep-G2 160 bp overlap
ChIP HepG2 ENCFF479OHI 485 bp overlap
ChIP HepG2 ENCFF507HCX 617 bp overlap
ChIP HepG2 ENCFF507HCX 499 bp overlap
ChIP Ishikawa ENCFF064TDQ 461 bp overlap
ChIP Ishikawa ENCSR000BTY.MAX.Ishikawa 198 bp overlap
ChIP MCF-7 ENCSR000BUL.MAX.MCF-7 169 bp overlap
MEF2A 6 datasets
Motif DE_12h DE_12h-MEF2A_MA0052.5 10 bp overlap
Motif DE_24h DE_24h-MEF2A_MA0052.5 10 bp overlap
Motif DE_36h DE_36h-MEF2A_MA0052.5 10 bp overlap
Motif DE_48h DE_48h-MEF2A_MA0052.5 10 bp overlap
Motif DE_60h DE_60h-MEF2A_MA0052.5 10 bp overlap
Motif DE_72h DE_72h-MEF2A_MA0052.5 10 bp overlap
MEF2C 6 datasets
Motif DE_12h DE_12h-MEF2C_MA0497.2 11 bp overlap
Motif DE_24h DE_24h-MEF2C_MA0497.2 11 bp overlap
Motif DE_36h DE_36h-MEF2C_MA0497.2 11 bp overlap
Motif DE_48h DE_48h-MEF2C_MA0497.2 11 bp overlap
Motif DE_60h DE_60h-MEF2C_MA0497.2 11 bp overlap
Motif DE_72h DE_72h-MEF2C_MA0497.2 11 bp overlap
MEIS1 7 datasets
Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap
Motif DE_24h DE_24h-MEIS1_MA0498.3 5 bp overlap
Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
Motif ES_0h ES_0h-MEIS1_MA0498.3 5 bp overlap
MTA1 1 dataset
ChIP HepG2 ENCFF038CCB 605 bp overlap
MYB 2 datasets
Motif DE_12h DE_12h-MYB_MA0100.4 6 bp overlap
Motif DE_60h DE_60h-MYB_MA0100.4 6 bp overlap
MYOCD 1 dataset
ChIP A-549 GSE128921.MYOCD.A-549 418 bp overlap
MYPOP 1 dataset
ChIP HepG2 ENCFF176TQL 657 bp overlap
NCOA2 1 dataset
ChIP MCF-7 ERP000901.NCOA2.MCF-7 133 bp overlap
NFE2 1 dataset
ChIP ProEs GSE59087.NFE2.ProEs 97 bp overlap
NONO 1 dataset
ChIP HepG2 ENCFF361UQH 302 bp overlap
NR3C1 1 dataset
ChIP A-549 ENCSR000BJR.NR3C1.A-549 138 bp overlap
NRF1 21 datasets
ChIP H1 ENCFF582PEJ 245 bp overlap
ChIP Hep-G2 GSE97661.NRF1.Hep-G2 609 bp overlap
ChIP Hep-G2 ENCSR853ADA.NRF1.Hep-G2 625 bp overlap
ChIP Hep-G2 ENCSR000EEH.NRF1.Hep-G2 101 bp overlap
ChIP HepG2 ENCFF694NVY 612 bp overlap
ChIP HepG2 ENCFF942ICJ 354 bp overlap
ChIP HepG2 ENCFF969ALM 261 bp overlap
ChIP K-562 ENCSR998AJK.NRF1.K-562 512 bp overlap
ChIP K-562 ENCSR837EYC.NRF1.K-562 342 bp overlap
ChIP K-562 ENCSR494TDU.NRF1.K-562 340 bp overlap
ChIP K-562 ENCSR000EHH.NRF1.K-562 108 bp overlap
ChIP K-562_Ab_R157-1-3D4 GSE97661.NRF1.K-562_Ab_R157-1-3D4 299 bp overlap
ChIP K-562_Ab_R157-1-3H1 GSE97661.NRF1.K-562_Ab_R157-1-3H1 184 bp overlap
ChIP K-562_Ab_R157-1-3H3 GSE97661.NRF1.K-562_Ab_R157-1-3H3 313 bp overlap
ChIP K562 ENCFF130SGK 399 bp overlap
ChIP K562 ENCFF689EWI 790 bp overlap
ChIP K562 ENCFF773FOM 241 bp overlap
ChIP K562 ENCFF791UHF 767 bp overlap
ChIP MCF-7_Ab_R157-1-3D4 GSE97661.NRF1.MCF-7_Ab_R157-1-3D4 467 bp overlap
ChIP MCF-7_Ab_R157-1-3H1 GSE97661.NRF1.MCF-7_Ab_R157-1-3H1 129 bp overlap
ChIP WA01 ENCSR000ECC.NRF1.WA01 203 bp overlap
Nrf1 7 datasets
Motif DE_12h DE_12h-Nrf1_MA0506.3 12 bp overlap
Motif DE_24h DE_24h-Nrf1_MA0506.3 12 bp overlap
Motif DE_36h DE_36h-Nrf1_MA0506.3 12 bp overlap
Motif DE_48h DE_48h-Nrf1_MA0506.3 12 bp overlap
Motif DE_60h DE_60h-Nrf1_MA0506.3 12 bp overlap
Motif DE_72h DE_72h-Nrf1_MA0506.3 12 bp overlap
Motif ES_0h ES_0h-Nrf1_MA0506.3 12 bp overlap
OGG1 3 datasets
ChIP HEK293 GSE89017.OGG1.HEK293 690 bp overlap
ChIP HEK293_15min GSE89017.OGG1.HEK293_15min 519 bp overlap
ChIP HEK293_60_min GSE89017.OGG1.HEK293_60_min 447 bp overlap
OLIG2 2 datasets
ChIP brain-prefrontal-cortex_2017014 GSE129039.OLIG2.brain-prefrontal-cortex_2017014 241 bp overlap
ChIP brain-prefrontal-cortex_2018006 GSE129039.OLIG2.brain-prefrontal-cortex_2018006 255 bp overlap
PCBP1 1 dataset
ChIP Hep-G2 GSE120104.PCBP1.Hep-G2 230 bp overlap
PCGF1 1 dataset
ChIP WA01 GSE104690.PCGF1.WA01 338 bp overlap
POLR2A 5 datasets
ChIP esophagus muscularis mucosa ENCFF759BBR 145 bp overlap
ChIP heart left ventricle ENCFF591JWH 445 bp overlap
ChIP heart left ventricle ENCFF591JWH 445 bp overlap
ChIP spleen ENCFF446ZGT 247 bp overlap
ChIP spleen ENCFF706IUS 261 bp overlap
POU5F1 1 dataset
ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 243 bp overlap
RBM39 5 datasets
ChIP Hep-G2 ENCSR339JTP.RBM39.Hep-G2 257 bp overlap
ChIP Hep-G2 GSE120104.RBM39.Hep-G2 261 bp overlap
ChIP HepG2 ENCFF084YZE 588 bp overlap
ChIP HepG2 ENCFF084YZE 681 bp overlap
ChIP HepG2 ENCFF801JUH 677 bp overlap
RBPJ 4 datasets
ChIP CUTLL1 GSE29600.RBPJ.CUTLL1 140 bp overlap
Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap
ChIP NHEK GSE29498.RBPJ.NHEK 190 bp overlap
ChIP NHEK GSE29498.RBPJ.NHEK 139 bp overlap
RORC 2 datasets
ChIP HCC70 GSE126380.RORC.HCC70 287 bp overlap
ChIP HCC70_XY018 GSE126380.RORC.HCC70_XY018 225 bp overlap
RXR 1 dataset
ChIP TSU-1621MT GSE60477.RXR.TSU-1621MT 201 bp overlap
SIRT6 1 dataset
ChIP SK-MEL-239_L-C-B GSE102813.SIRT6.SK-MEL-239_L-C-B 159 bp overlap
SMAD3 3 datasets
ChIP H69_4TGF GSE145250.SMAD3.H69_4TGF 228 bp overlap
ChIP H69_5TGF GSE145250.SMAD3.H69_5TGF 207 bp overlap
ChIP H69_5Veh GSE145250.SMAD3.H69_5Veh 126 bp overlap
SND1 1 dataset
ChIP NHEK GSE29498.SND1.NHEK 110 bp overlap
SP1 1 dataset
Motif DE_60h DE_60h-SP1_MA0079.5 9 bp overlap
SPIC 6 datasets
Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap
Motif DE_24h DE_24h-SPIC_MA0687.2 13 bp overlap
Motif DE_36h DE_36h-SPIC_MA0687.2 13 bp overlap
Motif DE_48h DE_48h-SPIC_MA0687.2 13 bp overlap
Motif DE_60h DE_60h-SPIC_MA0687.2 13 bp overlap
Motif DE_72h DE_72h-SPIC_MA0687.2 13 bp overlap
SREBP2 1 dataset
ChIP HCC70 GSE126380.SREBP2.HCC70 297 bp overlap
STAG2 3 datasets
ChIP HCAEC GSE101921.STAG2.HCAEC 267 bp overlap
ChIP MCF-10A_siSTAG1 GSE101921.STAG2.MCF-10A_siSTAG1 145 bp overlap
ChIP MCF-10A_siSTAG2 GSE101921.STAG2.MCF-10A_siSTAG2 166 bp overlap
STAT3 1 dataset
ChIP WA01 ERP004237.STAT3.WA01 203 bp overlap
SUZ12 1 dataset
ChIP ProEs GSE59087.SUZ12.ProEs 125 bp overlap
TAF15 5 datasets
ChIP Hep-G2 GSE120104.TAF15.Hep-G2 183 bp overlap
ChIP HepG2 ENCFF116QSW 497 bp overlap
ChIP HepG2 ENCFF116QSW 261 bp overlap
ChIP HepG2 ENCFF406BOT 481 bp overlap
ChIP HepG2 ENCFF406BOT 259 bp overlap
TAL1 1 dataset
ChIP ME-1 GSE46044.TAL1.ME-1 252 bp overlap
TFAP2C 1 dataset
ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 380 bp overlap
TFAP4::ETV1 3 datasets
Motif DE_12h DE_12h-TFAP4ETV1_MA1966.2 13 bp overlap
Motif DE_48h DE_48h-TFAP4ETV1_MA1966.2 13 bp overlap
Motif DE_60h DE_60h-TFAP4ETV1_MA1966.2 13 bp overlap
TFAP4::FLI1 3 datasets
Motif DE_12h DE_12h-TFAP4FLI1_MA1967.2 14 bp overlap
Motif DE_48h DE_48h-TFAP4FLI1_MA1967.2 14 bp overlap
Motif DE_60h DE_60h-TFAP4FLI1_MA1967.2 14 bp overlap
TP53 1 dataset
ChIP MDA-MB-231 GSE95303.TP53.MDA-MB-231 191 bp overlap
TP63 2 datasets
ChIP keratinocyte GSE33571.TP63.keratinocyte 134 bp overlap
ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 141 bp overlap
U2AF1 1 dataset
ChIP Hep-G2 GSE120104.U2AF1.Hep-G2 181 bp overlap
WDR5 1 dataset
ChIP SMMC-7721 GSE126982.WDR5.SMMC-7721 346 bp overlap
ZBTB2 2 datasets
ChIP K-562 ENCSR230PTV.ZBTB2.K-562 248 bp overlap
ChIP K562 ENCFF290ESQ 431 bp overlap
ZFP91 5 datasets
ChIP HepG2 ENCFF012CME 546 bp overlap
ChIP K-562 ENCSR898XMH.ZFP91.K-562 382 bp overlap
ChIP K562 ENCFF185FKB 361 bp overlap
ChIP K562 ENCFF501CDP 344 bp overlap
ChIP K562 ENCFF501CDP 456 bp overlap
ZFY 1 dataset
ChIP Hep-G2 ENCSR949OEV.ZFY.Hep-G2 166 bp overlap
ZNF16 2 datasets
Motif DE_60h DE_60h-ZNF16_MA1654.2 21 bp overlap
Motif DE_72h DE_72h-ZNF16_MA1654.2 21 bp overlap
ZNF280B 1 dataset
ChIP HepG2 ENCFF084BYB 248 bp overlap
ZNF320 2 datasets
Motif DE_12h DE_12h-ZNF320_MA1976.2 20 bp overlap
Motif DE_60h DE_60h-ZNF320_MA1976.2 20 bp overlap
ZNF48 1 dataset
ChIP HepG2 ENCFF362CDQ 591 bp overlap
ZNF549 5 datasets
Motif DE_12h DE_12h-ZNF549_MA1728.2 8 bp overlap
Motif DE_24h DE_24h-ZNF549_MA1728.2 8 bp overlap
Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap
Motif DE_60h DE_60h-ZNF549_MA1728.2 8 bp overlap
Motif DE_72h DE_72h-ZNF549_MA1728.2 8 bp overlap
ZNF610 6 datasets
Motif DE_12h DE_12h-ZNF610_MA1713.2 10 bp overlap
Motif DE_24h DE_24h-ZNF610_MA1713.2 10 bp overlap
Motif DE_36h DE_36h-ZNF610_MA1713.2 10 bp overlap
Motif DE_48h DE_48h-ZNF610_MA1713.2 10 bp overlap
Motif DE_60h DE_60h-ZNF610_MA1713.2 10 bp overlap
Motif DE_72h DE_72h-ZNF610_MA1713.2 10 bp overlap
ZNF639 2 datasets
ChIP K-562 ENCSR949NVY.ZNF639.K-562 330 bp overlap
ChIP K562 ENCFF267NLX 320 bp overlap
ZNF687 1 dataset
ChIP HepG2 ENCFF653WIX 478 bp overlap
ZNF865 1 dataset
ChIP HepG2 ENCFF472KAQ 205 bp overlap
ZNF93 6 datasets
Motif DE_12h DE_12h-ZNF93_MA1721.2 14 bp overlap
Motif DE_24h DE_24h-ZNF93_MA1721.2 14 bp overlap
Motif DE_36h DE_36h-ZNF93_MA1721.2 14 bp overlap
Motif DE_48h DE_48h-ZNF93_MA1721.2 14 bp overlap
Motif DE_60h DE_60h-ZNF93_MA1721.2 14 bp overlap
Motif DE_72h DE_72h-ZNF93_MA1721.2 14 bp overlap
ZSCAN21 1 dataset
ChIP HepG2 ENCFF676MFO 541 bp overlap
ZSCAN4 2 datasets
ChIP HEK293 ENCFF381BKT 162 bp overlap
ChIP HEK293 ENCSR211GNP.ZSCAN4.HEK293 133 bp overlap
Zic1::Zic2 4 datasets
Motif DE_12h DE_12h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap
Zic3 4 datasets
Motif DE_12h DE_12h-Zic3_MA0697.3 7 bp overlap
Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap
Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap
Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap