This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HNRNPC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:20,970,757–20,971,991 | 298.0 kb | Distal (>10kb) Multiome | 745 | |
| chr14:20,989,595–20,990,562 | 279.6 kb | Distal (>10kb) Multiome | 835 | |
| chr14:21,024,660–21,026,214 | 244.3 kb | Distal (>10kb) Multiome | 768 | |
| chr14:21,069,280–21,071,963 | 197.8 kb | Distal (>10kb) Multiome | 899 | |
| chr14:21,092,184–21,093,275 | 176.7 kb | Distal (>10kb) Multiome | 774 | |
| chr14:21,094,184–21,094,833 | 175.0 kb | Distal (>10kb) Multiome | 210 | |
| chr14:21,097,193–21,098,877 | 171.0 kb | Distal (>10kb) Multiome | 469 | |
| chr14:21,103,222–21,104,876 | 165.5 kb | Distal (>10kb) Multiome | 1128 | |
| chr14:21,191,911–21,192,845 | 77.3 kb | Distal (>10kb) Multiome | 463 | |
| chr14:21,268,822–21,270,154 | 213 bp | At TSS Multiome | 1029 | |
| chr14:21,308,204–21,309,328 | 39.4 kb | Distal (>10kb) Multiome | 647 | |
| chr14:21,383,896–21,384,850 | 114.8 kb | Distal (>10kb) Multiome | 931 | |
| chr14:21,436,834–21,437,890 | 167.9 kb | Distal (>10kb) Multiome | 875 | |
| chr14:21,455,683–21,456,683 | 186.8 kb | Distal (>10kb) Multiome | 862 | |
| chr14:21,476,573–21,477,687 | 207.6 kb | Distal (>10kb) Multiome | 931 | |
| chr14:21,510,804–21,511,761 | 241.9 kb | Distal (>10kb) Multiome | 972 | |
| chr14:21,525,630–21,527,355 | 257.0 kb | Distal (>10kb) Multiome | 627 | |
| chr14:21,534,439–21,535,312 | 265.4 kb | Distal (>10kb) Multiome | 146 | |
| chr14:21,536,256–21,537,359 | 267.5 kb | Distal (>10kb) Multiome | 181 | |
| chr14:21,557,417–21,557,905 | 288.2 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the HNRNPC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.