Transcription factors with Perturb-seq knockdown data for FAM182B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM182B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM182B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:25,857,954–25,858,847 | 1.1 kb | Proximal (<10kb) | 97 | |
| chr20:25,859,716–25,860,312 | at TSS | At TSS | 145 | |
| chr20:25,861,296–25,862,304 | 1.4 kb | Proximal (<10kb) | 271 | |
| chr20:25,863,036–25,863,935 | 3.1 kb | Proximal (<10kb) | 199 | |
| chr20:25,865,564–25,866,351 | 5.7 kb | Proximal (<10kb) | 186 | |
| chr20:25,867,953–25,868,741 | 8.1 kb | Proximal (<10kb) | 94 |
Genomic view of the FAM182B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.