Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYPOP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYPOP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYPOP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,607,096–45,607,695 | 295.2 kb | Distal (>10kb) Multiome | 526 | |
| chr19:45,615,654–45,616,944 | 286.5 kb | Distal (>10kb) Multiome | 480 | |
| chr19:45,632,406–45,633,148 | 269.9 kb | Distal (>10kb) Multiome | 358 | |
| chr19:45,638,965–45,639,696 | 263.3 kb | Distal (>10kb) Multiome | 477 | |
| chr19:45,640,813–45,642,557 | 260.3 kb | Distal (>10kb) Multiome | 865 | |
| chr19:45,643,187–45,644,012 | 259.0 kb | Distal (>10kb) Multiome | 542 | |
| chr19:45,645,389–45,646,343 | 256.7 kb | Distal (>10kb) Multiome | 566 | |
| chr19:45,667,856–45,668,417 | 234.6 kb | Distal (>10kb) Multiome | 386 | |
| chr19:45,668,914–45,669,719 | 233.3 kb | Distal (>10kb) Multiome | 611 | |
| chr19:45,670,481–45,671,446 | 231.6 kb | Distal (>10kb) Multiome | 361 | |
| chr19:45,676,875–45,678,209 | 225.1 kb | Distal (>10kb) Multiome | 418 | |
| chr19:45,681,530–45,682,004 | 220.9 kb | Distal (>10kb) Multiome | 648 | |
| chr19:45,691,622–45,693,062 | 210.2 kb | Distal (>10kb) Multiome | 943 | |
| chr19:45,716,851–45,718,343 | 185.1 kb | Distal (>10kb) Multiome | 895 | |
| chr19:45,730,200–45,731,219 | 171.6 kb | Distal (>10kb) Multiome | 740 | |
| chr19:45,767,223–45,771,892 | 133.2 kb | Distal (>10kb) Multiome | 1161 | |
| chr19:45,779,258–45,780,150 | 123.0 kb | Distal (>10kb) Multiome | 445 | |
| chr19:45,792,338–45,793,273 | 109.7 kb | Distal (>10kb) Multiome | 609 | |
| chr19:45,815,484–45,818,073 | 86.7 kb | Distal (>10kb) Multiome | 623 | |
| chr19:45,862,559–45,864,765 | 38.2 kb | Distal (>10kb) Multiome | 976 | |
| chr19:45,881,480–45,883,645 | 20.5 kb | Distal (>10kb) Multiome | 990 | |
| chr19:45,885,092–45,887,294 | 15.9 kb | Distal (>10kb) Multiome | 913 | |
| chr19:45,901,212–45,903,471 | 234 bp | At TSS Multiome | 780 | |
| chr19:45,952,967–45,953,485 | 50.5 kb | Distal (>10kb) Multiome | 329 | |
| chr19:45,973,761–45,974,227 | 71.4 kb | Distal (>10kb) Multiome | 201 | |
| chr19:45,994,774–45,995,740 | 92.7 kb | Distal (>10kb) Multiome | 660 | |
| chr19:46,014,941–46,015,784 | 112.8 kb | Distal (>10kb) Multiome | 220 | |
| chr19:46,016,414–46,017,078 | 114.3 kb | Distal (>10kb) Multiome | 364 | |
| chr19:46,076,819–46,077,882 | 175.0 kb | Distal (>10kb) Multiome HiCAR | 516 | |
| chr19:46,133,049–46,133,620 | 230.9 kb | Distal (>10kb) Multiome | 189 | |
| chr19:46,186,238–46,186,877 | 284.0 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the MYPOP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.