This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for NONO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NONO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NONO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:71,053,141–71,053,663 | 230.2 kb | Distal (>10kb) Multiome | 90 | |
| chrX:71,067,771–71,068,927 | 215.1 kb | Distal (>10kb) Multiome | 846 | |
| chrX:71,095,671–71,096,651 | 187.6 kb | Distal (>10kb) Multiome | 450 | |
| chrX:71,103,137–71,103,903 | 180.1 kb | Distal (>10kb) Multiome | 375 | |
| chrX:71,181,957–71,182,785 | 101.4 kb | Distal (>10kb) Multiome | 615 | |
| chrX:71,253,749–71,255,053 | 29.4 kb | Distal (>10kb) Multiome | 607 | |
| chrX:71,283,100–71,284,134 | 101 bp | At TSS Multiome | 633 | |
| chrX:71,365,705–71,366,636 | 82.5 kb | Distal (>10kb) Multiome | 578 | |
| chrX:71,532,799–71,533,342 | 249.3 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the NONO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.