chr7 : 33,901,770 33,903,544
1,774 bp 108 TFs 1 linked gene
This 1.8 kb open chromatin element is linked to BMPER and is bound by 108 transcription factors.
Linked Genes
1 gene
Gene Expression Dist. to TSS Distance Link type
BMPER 2.0 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr7:33,896,770 – 33,908,544
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
108 transcription factors
Source
Cell type
ARID1A 2 datasets
ChIP 12Z GSE129781.ARID1A.12Z 386 bp overlap
ChIP 12Z GSE129781.ARID1A.12Z 553 bp overlap
ATF2 1 dataset
ChIP WA01 ENCSR000BQU.ATF2.WA01 167 bp overlap
Atoh1 1 dataset
Motif DE_36h DE_36h-Atoh1_MA1467.3 7 bp overlap
BCOR 1 dataset
ChIP WA01 GSE104690.BCOR.WA01 165 bp overlap
BRD4 1 dataset
ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 175 bp overlap
CTBP2 1 dataset
ChIP WA01 ENCSR000EUO.CTBP2.WA01 212 bp overlap
CTCF 5 datasets
ChIP GM23338 ENCFF531QOI 425 bp overlap
ChIP H9 ENCFF152GTF 124 bp overlap
ChIP HFFc6 ENCFF005CJI 565 bp overlap
ChIP endodermal cell ENCFF471YCZ 191 bp overlap
ChIP hESC_D5 GSE116862.CTCF.hESC_D5 357 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF274GAT 385 bp overlap
DUX4 1 dataset
ChIP WA01 GSE94322.DUX4.WA01 294 bp overlap
EOMES 3 datasets
ChIP hESC GSE26097.EOMES.hESC 520 bp overlap
ChIP hESC GSE26097.EOMES.hESC 136 bp overlap
ChIP hESC GSE26097.EOMES.hESC 160 bp overlap
ETV1 5 datasets
Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap
Motif DE_36h DE_36h-ETV1_MA0761.3 9 bp overlap
Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap
Motif DE_60h DE_60h-ETV1_MA0761.3 9 bp overlap
Motif DE_72h DE_72h-ETV1_MA0761.3 9 bp overlap
EZH2 1 dataset
ChIP A-1847 GSE95643.EZH2.A-1847 446 bp overlap
FOXA1 3 datasets
ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 534 bp overlap
ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 243 bp overlap
ChIP breast-cancer_Veh-2860 GSE128018.FOXA1.breast-cancer_Veh-2860 230 bp overlap
FOXA2 3 datasets
ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 206 bp overlap
ChIP DE DE-FOXA2-1 1718 bp overlap
ChIP DE DE-FOXA2-2 1705 bp overlap
Foxl2 4 datasets
Motif DE_36h DE_36h-Foxl2_MA1607.2 10 bp overlap
Motif DE_48h DE_48h-Foxl2_MA1607.2 10 bp overlap
Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap
Motif DE_72h DE_72h-Foxl2_MA1607.2 10 bp overlap
GATA2 2 datasets
ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 320 bp overlap
ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 219 bp overlap
GATA4 6 datasets
ChIP DE DE-GATA4-1 1760 bp overlap
ChIP DE DE-GATA4-2 1740 bp overlap
ChIP Hep-G2 GSE135714.GATA4.Hep-G2 197 bp overlap
ChIP foregut GSE117136.GATA4.foregut 340 bp overlap
ChIP foregut GSE117136.GATA4.foregut 407 bp overlap
ChIP foregut GSE117136.GATA4.foregut 262 bp overlap
GATA6 16 datasets
ChIP DE DE-GATA6-1 1767 bp overlap
ChIP DE DE-GATA6-2 1773 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 806 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 875 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 1773 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 574 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 703 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 1740 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 778 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 692 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 561 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 294 bp overlap
ChIP foregut GSE117136.GATA6.foregut 306 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 426 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 289 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 429 bp overlap
HAND2 1 dataset
Motif DE_36h DE_36h-HAND2_MA1638.2 6 bp overlap
HOXA9 1 dataset
ChIP HEK293-FT GSE62586.HOXA9.HEK293-FT 152 bp overlap
Hic1 4 datasets
Motif DE_36h DE_36h-Hic1_MA0739.2 8 bp overlap
Motif DE_48h DE_48h-Hic1_MA0739.2 8 bp overlap
Motif DE_60h DE_60h-Hic1_MA0739.2 8 bp overlap
Motif DE_72h DE_72h-Hic1_MA0739.2 8 bp overlap
IKZF1 1 dataset
Motif DE_36h DE_36h-IKZF1_MA1508.2 8 bp overlap
IKZF2 4 datasets
Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap
Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap
Motif DE_60h DE_60h-IKZF2_MA2326.1 6 bp overlap
Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap
IRF5 4 datasets
Motif DE_36h DE_36h-IRF5_MA1420.1 14 bp overlap
Motif DE_48h DE_48h-IRF5_MA1420.1 14 bp overlap
Motif DE_60h DE_60h-IRF5_MA1420.1 14 bp overlap
Motif DE_72h DE_72h-IRF5_MA1420.1 14 bp overlap
IRF6 4 datasets
Motif DE_36h DE_36h-IRF6_MA1509.1 9 bp overlap
Motif DE_48h DE_48h-IRF6_MA1509.1 9 bp overlap
Motif DE_60h DE_60h-IRF6_MA1509.1 9 bp overlap
Motif DE_72h DE_72h-IRF6_MA1509.1 9 bp overlap
Ikzf3 4 datasets
Motif DE_36h DE_36h-Ikzf3_MA1992.2 9 bp overlap
Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap
Motif DE_60h DE_60h-Ikzf3_MA1992.2 9 bp overlap
Motif DE_72h DE_72h-Ikzf3_MA1992.2 9 bp overlap
JARID2 1 dataset
ChIP UTEIPS6 GSE48516.JARID2.UTEIPS6 306 bp overlap
JUN 1 dataset
ChIP DE_D2 S02-DE-d2-JUN-exp1 365 bp overlap
JUNB 1 dataset
ChIP HAEC GSE89970.JUNB.HAEC 275 bp overlap
KDM1A 1 dataset
ChIP NCI-H526_DMSO GSE66297.KDM1A.NCI-H526_DMSO 284 bp overlap
KLF4 1 dataset
ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 139 bp overlap
LIN54 4 datasets
Motif DE_36h DE_36h-LIN54_MA0619.2 7 bp overlap
Motif DE_48h DE_48h-LIN54_MA0619.2 7 bp overlap
Motif DE_60h DE_60h-LIN54_MA0619.2 7 bp overlap
Motif DE_72h DE_72h-LIN54_MA0619.2 7 bp overlap
MEIS1 1 dataset
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
MITF 2 datasets
ChIP 501-mel GSE137522.MITF.501-mel 292 bp overlap
ChIP 501-mel_K243Q GSE137522.MITF.501-mel_K243Q 267 bp overlap
MYB 1 dataset
Motif DE_60h DE_60h-MYB_MA0100.4 6 bp overlap
Msgn1 1 dataset
Motif DE_60h DE_60h-Msgn1_MA1524.3 10 bp overlap
NANOG 4 datasets
ChIP HUES-8 GSE109524.NANOG.HUES-8 307 bp overlap
ChIP WA01 ERP004238.NANOG.WA01 273 bp overlap
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 417 bp overlap
ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 219 bp overlap
NFYB 1 dataset
Motif DE_36h DE_36h-NFYB_MA0502.3 9 bp overlap
NRL 1 dataset
Motif DE_60h DE_60h-NRL_MA0842.3 12 bp overlap
Neurod2 2 datasets
Motif DE_36h DE_36h-Neurod2_MA0668.3 8 bp overlap
Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap
Nkx2-1 1 dataset
Motif DE_60h DE_60h-Nkx2-1_MA1994.2 7 bp overlap
Nr2e3 2 datasets
Motif DE_36h DE_36h-Nr2e3_MA0164.2 6 bp overlap
Motif DE_60h DE_60h-Nr2e3_MA0164.2 6 bp overlap
OTX2 1 dataset
ChIP WTC11 ENCFF634NAO 245 bp overlap
Olig2 1 dataset
Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap
PHOX2B 2 datasets
ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 277 bp overlap
ChIP SK-N-BE2-C GSE94822.PHOX2B.SK-N-BE2-C 160 bp overlap
POU2F3 1 dataset
ChIP NCI-H1048 GSE115123.POU2F3.NCI-H1048 261 bp overlap
POU3F1 1 dataset
ChIP SKM-1_D2 GSE93706.POU3F1.SKM-1_D2 212 bp overlap
POU3F2 1 dataset
ChIP hiPSC_SGC0946 GSE149017.POU3F2.hiPSC_SGC0946 211 bp overlap
POU5F1 1 dataset
ChIP BJ_INDUCED GSE36570.POU5F1.BJ_INDUCED 225 bp overlap
PSIP1 1 dataset
ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 151 bp overlap
Plagl1 1 dataset
Motif DE_36h DE_36h-Plagl1_MA1615.2 8 bp overlap
RING1 2 datasets
ChIP SYO-1_shCt GSE139053.RING1.SYO-1_shCt 298 bp overlap
ChIP SYO-1_shRING1A-B GSE139053.RING1.SYO-1_shRING1A-B 827 bp overlap
RNF2 4 datasets
ChIP SYO-1_shCt GSE139053.RNF2.SYO-1_shCt 772 bp overlap
ChIP SYO-1_shRING1A-B GSE139053.RNF2.SYO-1_shRING1A-B 489 bp overlap
ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 216 bp overlap
ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 251 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 689 bp overlap
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 414 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 691 bp overlap
SMAD2_3 7 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 369 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 392 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 905 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 1681 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 665 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 300 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 250 bp overlap
SMARCA4 2 datasets
ChIP SYO-1 GSE108025.SMARCA4.SYO-1 1031 bp overlap
ChIP SYO-1 GSE108025.SMARCA4.SYO-1 341 bp overlap
SMARCC1 5 datasets
ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 187 bp overlap
ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 457 bp overlap
ChIP DE_D1 S15-DE-d1-BAF155-exp1 952 bp overlap
ChIP SYO-1_shCt GSE139053.SMARCC1.SYO-1_shCt 245 bp overlap
ChIP SYO-1_shCt GSE139053.SMARCC1.SYO-1_shCt 449 bp overlap
SOX10 4 datasets
Motif DE_36h DE_36h-SOX10_MA0442.3 6 bp overlap
Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap
Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap
Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap
SOX17 2 datasets
ChIP DE_D2 DED2-SOX17_Batch_II 268 bp overlap
ChIP DE_D2 DED2-SOX17_Batch_II 270 bp overlap
SOX17_M 2 datasets
ChIP DE_D2 DED2-SOX17-M_Batch_II 376 bp overlap
ChIP DE_D2 DED2-SOX17-M_Batch_II 293 bp overlap
SOX2 1 dataset
ChIP hiPSC GSE56567.SOX2.hiPSC 178 bp overlap
SREBF1 1 dataset
Motif DE_60h DE_60h-SREBF1_MA0829.3 10 bp overlap
SREBF2 1 dataset
Motif DE_60h DE_60h-SREBF2_MA0828.3 10 bp overlap
SS18 2 datasets
ChIP Aska-SS_BAF47KO1 GSE108025.SS18.Aska-SS_BAF47KO1 611 bp overlap
ChIP SYO-1_shRING1A-B GSE139053.SS18.SYO-1_shRING1A-B 762 bp overlap
STAT1 4 datasets
Motif DE_36h DE_36h-STAT1_MA0137.4 9 bp overlap
Motif DE_48h DE_48h-STAT1_MA0137.4 9 bp overlap
Motif DE_60h DE_60h-STAT1_MA0137.4 9 bp overlap
Motif DE_72h DE_72h-STAT1_MA0137.4 9 bp overlap
Spz1 4 datasets
Motif DE_36h DE_36h-Spz1_MA0111.1 11 bp overlap
Motif DE_48h DE_48h-Spz1_MA0111.1 11 bp overlap
Motif DE_60h DE_60h-Spz1_MA0111.1 11 bp overlap
Motif DE_72h DE_72h-Spz1_MA0111.1 11 bp overlap
Stat5a 4 datasets
Motif DE_36h DE_36h-Stat5a_MA1624.2 9 bp overlap
Motif DE_48h DE_48h-Stat5a_MA1624.2 9 bp overlap
Motif DE_60h DE_60h-Stat5a_MA1624.2 9 bp overlap
Motif DE_72h DE_72h-Stat5a_MA1624.2 9 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 193 bp overlap
TCF12 2 datasets
ChIP SK-N-SH ENCFF147AHB 107 bp overlap
ChIP WA01 ENCSR000BIT.TCF12.WA01 159 bp overlap
TCF3 1 dataset
ChIP NPC GSE154479.TCF3.NPC 285 bp overlap
TEAD4 1 dataset
ChIP H1 ENCFF778PAX 245 bp overlap
TFAP4 1 dataset
Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap
TGIF2LX 1 dataset
Motif DE_60h DE_60h-TGIF2LX_MA1571.1 12 bp overlap
TGIF2LY 1 dataset
Motif DE_60h DE_60h-TGIF2LY_MA1572.1 12 bp overlap
THAP1 4 datasets
Motif DE_36h DE_36h-THAP1_MA0597.3 8 bp overlap
Motif DE_48h DE_48h-THAP1_MA0597.3 8 bp overlap
Motif DE_60h DE_60h-THAP1_MA0597.3 8 bp overlap
Motif DE_72h DE_72h-THAP1_MA0597.3 8 bp overlap
THRA 1 dataset
Motif DE_36h DE_36h-THRA_MA1969.2 18 bp overlap
TRIM28 1 dataset
ChIP hESC GSE115387.TRIM28.hESC 345 bp overlap
TRPS1 1 dataset
ChIP T-47D GSE107013.TRPS1.T-47D 121 bp overlap
Tcf12 1 dataset
Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap
Tfcp2l1 4 datasets
Motif DE_36h DE_36h-Tfcp2l1_MA0145.2 14 bp overlap
Motif DE_48h DE_48h-Tfcp2l1_MA0145.2 14 bp overlap
Motif DE_60h DE_60h-Tfcp2l1_MA0145.2 14 bp overlap
Motif DE_72h DE_72h-Tfcp2l1_MA0145.2 14 bp overlap
Twist2 1 dataset
Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap
UBN1 1 dataset
ChIP HeLa GSE45024.UBN1.HeLa 279 bp overlap
YAP1 1 dataset
ChIP MCF-10A GSE97972.YAP1.MCF-10A 140 bp overlap
YY1 1 dataset
ChIP WA01 ENCSR000BKD.YY1.WA01 150 bp overlap
ZBTB6 4 datasets
Motif DE_36h DE_36h-ZBTB6_MA1581.2 9 bp overlap
Motif DE_48h DE_48h-ZBTB6_MA1581.2 9 bp overlap
Motif DE_60h DE_60h-ZBTB6_MA1581.2 9 bp overlap
Motif DE_72h DE_72h-ZBTB6_MA1581.2 9 bp overlap
ZIC1 4 datasets
Motif DE_36h DE_36h-ZIC1_MA0696.1 14 bp overlap
Motif DE_48h DE_48h-ZIC1_MA0696.1 14 bp overlap
Motif DE_60h DE_60h-ZIC1_MA0696.1 14 bp overlap
Motif DE_72h DE_72h-ZIC1_MA0696.1 14 bp overlap
ZIC4 4 datasets
Motif DE_36h DE_36h-ZIC4_MA0751.2 14 bp overlap
Motif DE_48h DE_48h-ZIC4_MA0751.2 14 bp overlap
Motif DE_60h DE_60h-ZIC4_MA0751.2 14 bp overlap
Motif DE_72h DE_72h-ZIC4_MA0751.2 14 bp overlap
ZIC5 4 datasets
Motif DE_36h DE_36h-ZIC5_MA1584.2 15 bp overlap
Motif DE_48h DE_48h-ZIC5_MA1584.2 15 bp overlap
Motif DE_60h DE_60h-ZIC5_MA1584.2 15 bp overlap
Motif DE_72h DE_72h-ZIC5_MA1584.2 15 bp overlap
ZNF175 1 dataset
Motif DE_36h DE_36h-ZNF175_MA2332.1 9 bp overlap
ZNF189 1 dataset
Motif DE_36h DE_36h-ZNF189_MA1725.2 9 bp overlap
ZNF213 4 datasets
Motif DE_36h DE_36h-ZNF213_MA2121.1 12 bp overlap
Motif DE_48h DE_48h-ZNF213_MA2121.1 12 bp overlap
Motif DE_60h DE_60h-ZNF213_MA2121.1 12 bp overlap
Motif DE_72h DE_72h-ZNF213_MA2121.1 12 bp overlap
ZNF317 4 datasets
Motif DE_36h DE_36h-ZNF317_MA1593.2 8 bp overlap
Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap
Motif DE_60h DE_60h-ZNF317_MA1593.2 8 bp overlap
Motif DE_72h DE_72h-ZNF317_MA1593.2 8 bp overlap
ZNF320 1 dataset
Motif DE_36h DE_36h-ZNF320_MA1976.2 20 bp overlap
ZNF436 1 dataset
ChIP HEK293 GSE76494.ZNF436.HEK293 177 bp overlap
ZNF462 2 datasets
ChIP GM23338 ENCFF896CCA 251 bp overlap
ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 303 bp overlap
ZNF549 4 datasets
Motif DE_36h DE_36h-ZNF549_MA1728.2 8 bp overlap
Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap
Motif DE_60h DE_60h-ZNF549_MA1728.2 8 bp overlap
Motif DE_72h DE_72h-ZNF549_MA1728.2 8 bp overlap
ZNF573 1 dataset
ChIP HEK293T GSE78099.ZNF573.HEK293T 185 bp overlap
ZNF667 4 datasets
Motif DE_36h DE_36h-ZNF667_MA1984.2 11 bp overlap
Motif DE_48h DE_48h-ZNF667_MA1984.2 11 bp overlap
Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap
Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap
ZNF768 4 datasets
Motif DE_36h DE_36h-ZNF768_MA1731.2 9 bp overlap
Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap
Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap
Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap
Zic1::Zic2 4 datasets
Motif DE_36h DE_36h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap
Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap
Zic2 4 datasets
Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap
Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap
Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap
Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap
Zic3 4 datasets
Motif DE_36h DE_36h-Zic3_MA0697.3 7 bp overlap
Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap
Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap
Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap