Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for UBN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,585,331–4,585,992 | 261.8 kb | Distal (>10kb) Multiome | 223 | |
| chr16:4,613,912–4,617,164 | 232.6 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:4,624,301–4,625,703 | 222.8 kb | Distal (>10kb) Multiome | 866 | |
| chr16:4,693,016–4,694,663 | 153.9 kb | Distal (>10kb) Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 113.0 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 80.2 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 78.7 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 45.2 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 68 bp | At TSS Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 89.8 kb | Distal (>10kb) Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 95.9 kb | Distal (>10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 110.7 kb | Distal (>10kb) Multiome | 802 | |
| chr16:5,010,592–5,011,132 | 163.3 kb | Distal (>10kb) Multiome | 136 | |
| chr16:5,033,461–5,034,081 | 186.4 kb | Distal (>10kb) Multiome | 932 | |
| chr16:5,071,693–5,072,259 | 224.5 kb | Distal (>10kb) Multiome | 940 | |
| chr16:5,097,069–5,098,979 | 250.6 kb | Distal (>10kb) Multiome | 638 |
Genomic view of the UBN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.