This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for BMPER. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMPER upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMPER, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:33,705,164–33,706,374 | 199.9 kb | Distal (>10kb) Multiome | 207 | |
| chr7:33,722,409–33,723,198 | 182.8 kb | Distal (>10kb) Multiome HiCAR | 390 | |
| chr7:33,723,981–33,725,408 | 181.2 kb | Distal (>10kb) Multiome HiCAR | 121 | |
| chr7:33,733,904–33,734,626 | 171.3 kb | Distal (>10kb) Multiome HiCAR | 124 | |
| chr7:33,760,736–33,761,975 | 144.4 kb | Distal (>10kb) Multiome HiCAR | 199 | |
| chr7:33,852,976–33,853,999 | 52.0 kb | Distal (>10kb) Multiome | 71 | |
| chr7:33,885,992–33,886,676 | 19.2 kb | Distal (>10kb) Multiome | 131 | |
| chr7:33,895,137–33,895,794 | 9.8 kb | Proximal (<10kb) | 282 | |
| chr7:33,897,929–33,898,129 | 7.5 kb | Proximal (<10kb) | 7 | |
| chr7:33,899,466–33,900,323 | 5.3 kb | Proximal (<10kb) | 16 | |
| chr7:33,901,770–33,903,544 | 2.0 kb | Proximal (<10kb) | 108 | |
| chr7:33,903,647–33,905,958 | 62 bp | At TSS Multiome | 464 | |
| chr7:33,939,006–33,939,864 | 33.8 kb | Distal (>10kb) Multiome | 113 | |
| chr7:33,945,850–33,946,487 | 40.7 kb | Distal (>10kb) Multiome | 74 |
Genomic view of the BMPER locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.