chr16:57,630,443–57,631,059

chr16 : 57,630,443 – 57,631,059

616 bp 129 TFs 6 linked genes

This 616 bp open chromatin element is linked to 6 target genes and is bound by 129 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
CCDC102A		94.1 kb	Distal	Multiome
KATNB1		105.2 kb	Distal	Multiome+HiCAR
POLR2C		168.0 kb	Distal	Multiome
COQ9		183.2 kb	Distal	Multiome
CIAPIN1		183.2 kb	Distal	Multiome
KIFC3		215.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

129 transcription factors

ChIP LNCaP_ETOH GSE69043.AR.LNCaP_ETOH 116 bp overlap

ChIP LNCaP_SHGATA2_R1881 GSE69043.AR.LNCaP_SHGATA2_R1881 121 bp overlap

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 96 bp overlap

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 101 bp overlap

ChIP prostate_fetal-fibroblast GSE90772.AR.prostate_fetal-fibroblast 188 bp overlap

ARID1A 1 dataset

ChIP RMG-I GSE104545.ARID1A.RMG-I 112 bp overlap

ARID2 1 dataset

ChIP Aska-SS GSE108025.ARID2.Aska-SS 152 bp overlap

Ahr::Arnt 1 dataset

Motif DE_36h DE_36h-AhrArnt_MA0006.2 5 bp overlap

BCL11A 1 dataset

ChIP HUDEP-2_BCL11A-ER-V5 GSE103445.BCL11A.HUDEP-2_BCL11A-ER-V5 273 bp overlap

BRD2 3 datasets

ChIP SK-MEL-147 GSE94488.BRD2.SK-MEL-147 112 bp overlap

ChIP SK-MEL-147 GSE94488.BRD2.SK-MEL-147 120 bp overlap

ChIP SK-MEL-147_JQ1 GSE94488.BRD2.SK-MEL-147_JQ1 235 bp overlap

BRD4 2 datasets

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 342 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 115 bp overlap

CTBP1 3 datasets

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 494 bp overlap

ChIP K562 ENCFF403WPG 397 bp overlap

ChIP K562 ENCFF403WPG 544 bp overlap

ChIP 786-O_NORMOXIA GSE78113.CTCF.786-O_NORMOXIA 285 bp overlap

CTCFL 1 dataset

ChIP FT282 GSE131931.CTCFL.FT282 170 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 232 bp overlap

DNMT3B 1 dataset

ChIP HUES-8_TripleKO-TET1-2-3 GSE99346.DNMT3B.HUES-8_TripleKO-TET1-2-3 448 bp overlap

Motif DE_48h DE_48h-EHF_MA0598.4 9 bp overlap

Motif DE_48h DE_48h-ELF1_MA0473.4 9 bp overlap

Motif DE_48h DE_48h-ELF3_MA0640.3 9 bp overlap

EOMES 2 datasets

Motif DE_36h DE_36h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 264 bp overlap

EP300 1 dataset

ChIP HeLa-S3 ENCSR680OFU.EP300.HeLa-S3 145 bp overlap

ERF::FOXI1 1 dataset

Motif DE_48h DE_48h-ERFFOXI1_MA1935.2 10 bp overlap

ERF::FOXO1 1 dataset

Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap

ESR1 8 datasets

ChIP Ishikawa_DMSO GSE132426.ESR1.Ishikawa_DMSO 128 bp overlap

ChIP Ishikawa_DMSO_D538G_clone3 GSE132426.ESR1.Ishikawa_DMSO_D538G_clone3 91 bp overlap

ChIP Ishikawa_E2 GSE132426.ESR1.Ishikawa_E2 184 bp overlap

ChIP T-47D_D538G_E2 GSE148277.ESR1.T-47D_D538G_E2 422 bp overlap

ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 420 bp overlap

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 363 bp overlap

ChIP breast_tumor_Male_10 GSE104399.ESR1.breast_tumor_Male_10 387 bp overlap

ChIP breast_tumor_Male_26 GSE104399.ESR1.breast_tumor_Male_26 169 bp overlap

ESR1_pS118 1 dataset

ChIP MCF-7_E2_sc GSE117569.ESR1_pS118.MCF-7_E2_sc 196 bp overlap

Motif DE_48h DE_48h-ETV1_MA0761.3 9 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap

Motif DE_48h DE_48h-ETV7_MA1708.2 9 bp overlap

ChIP SU-DHL-6_DMSO GSE134136.EZH2.SU-DHL-6_DMSO 235 bp overlap

Motif DE_48h DE_48h-Elf5_MA0136.4 8 bp overlap

Motif DE_48h DE_48h-Erg_MA0474.4 10 bp overlap

FIGLA 1 dataset

Motif DE_36h DE_36h-FIGLA_MA0820.2 6 bp overlap

ChIP HCT-116_A7A GSE152144.FOS.HCT-116_A7A 264 bp overlap

FOXA1 2 datasets

ChIP T-47D_CR3flp GSE99479.FOXA1.T-47D_CR3flp 163 bp overlap

ChIP breast_tumor_Male_13 GSE104399.FOXA1.breast_tumor_Male_13 325 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 397 bp overlap

ChIP DE DE-FOXA2-2 454 bp overlap

FOXJ2 1 dataset

ChIP K562 ENCFF457GZC 530 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_48h DE_48h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_48h DE_48h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap

FOXP2 1 dataset

ChIP PFSK1 ENCSR000BGA.FOXP2.PFSK1 167 bp overlap

GABPA 1 dataset

Motif DE_48h DE_48h-GABPA_MA0062.4 10 bp overlap

GATA1 14 datasets

ChIP CD34_Day7_30min GSE104676.GATA1.CD34_Day7_30min 55 bp overlap

ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 109 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 332 bp overlap

ChIP K-562 ENCSR000EWM.GATA1.K-562 278 bp overlap

ChIP K-562 ENCSR000EFT.GATA1.K-562 152 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 256 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 262 bp overlap

ChIP erythroblast ENCFF867JAR 534 bp overlap

ChIP erythroblast ENCSR000EXP.GATA1.erythroblast 491 bp overlap

ChIP erythroid-progenitor GSE124163.GATA1.erythroid-progenitor 273 bp overlap

ChIP erythroid-progenitor_EPrec GSE124163.GATA1.erythroid-progenitor_EPrec 272 bp overlap

ChIP erythroid_Don001 GSE137982.GATA1.erythroid_Don001 321 bp overlap

ChIP erythroid_Don002 GSE137982.GATA1.erythroid_Don002 345 bp overlap

ChIP erythroid_Don003 GSE137982.GATA1.erythroid_Don003 341 bp overlap

GATA1::TAL1 1 dataset

Motif DE_36h DE_36h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 13 datasets

ChIP CD34_ACY957 GSE60792.GATA2.CD34_ACY957 306 bp overlap

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

ChIP K-562 ENCSR000EWG.GATA2.K-562 122 bp overlap

ChIP K562 ENCFF088XQT 411 bp overlap

ChIP LNCaP GSE38391.GATA2.LNCaP 274 bp overlap

ChIP LNCaP GSE52725.GATA2.LNCaP 274 bp overlap

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 165 bp overlap

ChIP ME-1_CBFB-MYH11-KD GSE117138.GATA2.ME-1_CBFB-MYH11-KD 337 bp overlap

ChIP SH-SY5Y ENCFF485YIB 405 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 217 bp overlap

ChIP SKH1 GSE87283.GATA2.SKH1 219 bp overlap

ChIP SKH1_RUNX1-EVI1_KD GSE87283.GATA2.SKH1_RUNX1-EVI1_KD 216 bp overlap

ChIP endothelial_umbilical-vein ENCSR000EVW.GATA2.endothelial_umbilical-vein 320 bp overlap

GATA3 5 datasets

ChIP Kelly GSE65664.GATA3.Kelly 170 bp overlap

ChIP MCF-7 ENCSR000EWS.GATA3.MCF-7 268 bp overlap

ChIP T-47D GSE51274.GATA3.T-47D 327 bp overlap

ChIP T-47D ENCSR000BMX.GATA3.T-47D 193 bp overlap

ChIP thymocyte GSE71751.GATA3.thymocyte 233 bp overlap

GATA3_Cter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Cter.T-47D_CR3flp 191 bp overlap

GATA3_Nter 2 datasets

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 332 bp overlap

ChIP T-47D_flp-ctrl GSE99479.GATA3_Nter.T-47D_flp-ctrl 308 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 416 bp overlap

ChIP DE DE-GATA4-2 518 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 368 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 277 bp overlap

ChIP DE DE-GATA6-2 415 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 337 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 454 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 434 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 322 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 594 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 445 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 397 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 276 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 199 bp overlap

GLIS2 1 dataset

ChIP HEK293 ENCSR535DIA.GLIS2.HEK293 110 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 419 bp overlap

GTF2I 1 dataset

ChIP K562 ENCFF539BYI 405 bp overlap

Gata3 1 dataset

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

IKZF1 1 dataset

Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap

IKZF2 1 dataset

Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap

Ikzf3 1 dataset

Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap

KDM1A 4 datasets

ChIP SET-2_GSK GSE121424.KDM1A.SET-2_GSK 75 bp overlap

ChIP SKNO-1_RN1 GSE71739.KDM1A.SKNO-1_RN1 443 bp overlap

ChIP pancreatic-progenitor_GT GSE104840.KDM1A.pancreatic-progenitor_GT 542 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 367 bp overlap

KLF11 1 dataset

Motif DE_36h DE_36h-KLF11_MA1512.2 10 bp overlap

ChIP GBM1A GSE62211.KLF9.GBM1A 163 bp overlap

KMT2A 1 dataset

ChIP IMS-M2_DMSO GSE129636.KMT2A.IMS-M2_DMSO 264 bp overlap

MEIS1 2 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_36h DE_36h-MGA_MA0801.1 8 bp overlap

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

Motif DE_36h DE_36h-MYF6_MA0667.1 10 bp overlap

MYOD1 1 dataset

ChIP IMR-90_GM GSE128527.MYOD1.IMR-90_GM 279 bp overlap

NANOG 2 datasets

ChIP LNCaP_pNanog1_Dox GSE74799.NANOG.LNCaP_pNanog1_Dox 240 bp overlap

ChIP LNCaP_pNanog8_Dox GSE74799.NANOG.LNCaP_pNanog8_Dox 369 bp overlap

NEUROD1 1 dataset

ChIP K-562 ENCSR986CDX.NEUROD1.K-562 115 bp overlap

Nr2e3 1 dataset

Motif DE_36h DE_36h-Nr2e3_MA0164.2 6 bp overlap

PATZ1 1 dataset

ChIP HEK293 ENCSR966ULI.PATZ1.HEK293 193 bp overlap

Motif DE_36h DE_36h-PBX3_MA1114.2 11 bp overlap

Motif DE_36h DE_36h-PGR_MA2327.1 9 bp overlap

PKNOX1 3 datasets

ChIP K-562 ENCSR115SMW.PKNOX1.K-562 334 bp overlap

ChIP K562 ENCFF236IUS 390 bp overlap

ChIP MCF-7 ENCSR986XYK.PKNOX1.MCF-7 288 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 326 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 462 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 461 bp overlap

PRDM9 1 dataset

Motif DE_36h DE_36h-PRDM9_MA1723.2 20 bp overlap

PTBP1 2 datasets

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 104 bp overlap

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 57 bp overlap

Prdm5 1 dataset

Motif DE_36h DE_36h-Prdm5_MA1999.2 11 bp overlap

Ptf1A 1 dataset

Motif DE_36h DE_36h-Ptf1A_MA1620.2 8 bp overlap

RBM39 2 datasets

ChIP HepG2 ENCFF084YZE 99 bp overlap

ChIP HepG2 ENCFF801JUH 97 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 201 bp overlap

RPA2_phospho 1 dataset

ChIP HeLa GSE108172.RPA2_phospho.HeLa 616 bp overlap

RUNX1_mut 1 dataset

ChIP CD34 GSE111917.RUNX1_mut.CD34 256 bp overlap

SIRT6 1 dataset

ChIP SK-MEL-239_L-C-B GSE102813.SIRT6.SK-MEL-239_L-C-B 113 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 254 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 598 bp overlap

SMARCA4 3 datasets

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 357 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 291 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 174 bp overlap

SMARCE1 1 dataset

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 237 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 372 bp overlap

SOX6 2 datasets

ChIP K-562 ENCSR788RSW.SOX6.K-562 312 bp overlap

ChIP K562 ENCFF059YCJ 437 bp overlap

ChIP Hep-G2 ENCSR460YAM.SP1.Hep-G2 104 bp overlap

Motif DE_36h DE_36h-SP9_MA1564.2 10 bp overlap

SPI1 2 datasets

ChIP CTV-1_delQ GSE128835.SPI1.CTV-1_delQ 194 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 150 bp overlap

Motif DE_48h DE_48h-SPIB_MA0081.3 13 bp overlap

Motif DE_48h DE_48h-SPIC_MA0687.2 13 bp overlap

SREBF1 2 datasets

Motif DE_36h DE_36h-SREBF1_MA0595.1 10 bp overlap

Motif DE_48h DE_48h-SREBF1_MA0595.1 10 bp overlap

SREBF2 2 datasets

Motif DE_36h DE_36h-SREBF2_MA0596.1 10 bp overlap

Motif DE_48h DE_48h-SREBF2_MA0596.1 10 bp overlap

SREBP2 2 datasets

ChIP monocyte GSE129202.SREBP2.monocyte 309 bp overlap

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 313 bp overlap

ChIP Aska-SS_BAF47KO1 GSE108025.SS18.Aska-SS_BAF47KO1 616 bp overlap

STAT1_pS727 1 dataset

ChIP SET-2 GSE100566.STAT1_pS727.SET-2 202 bp overlap

SUZ12 1 dataset

ChIP Karpas-422_CPI360-D8 GSE134136.SUZ12.Karpas-422_CPI360-D8 274 bp overlap

Motif DE_48h DE_48h-Spi1_MA0080.7 13 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 257 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 295 bp overlap

ChIP CD34 GSE52924.TAL1.CD34 185 bp overlap

Motif DE_36h DE_36h-TBR1_MA0802.2 9 bp overlap

Motif DE_36h DE_36h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_36h DE_36h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_36h DE_36h-TBX18_MA1565.2 9 bp overlap

Motif DE_36h DE_36h-TBX2_MA0688.2 9 bp overlap

TBX21 1 dataset

Motif DE_36h DE_36h-TBX21_MA0690.3 10 bp overlap

Motif DE_36h DE_36h-TBX3_MA1566.3 9 bp overlap

Motif DE_36h DE_36h-TBX4_MA0806.1 8 bp overlap

Motif DE_36h DE_36h-TBX5_MA0807.1 8 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 114 bp overlap

TRPS1 1 dataset

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Motif DE_36h DE_36h-Tbx6_MA1567.3 9 bp overlap

ZBTB18 1 dataset

Motif DE_36h DE_36h-ZBTB18_MA0698.2 11 bp overlap

Motif DE_36h DE_36h-ZEB1_MA0103.4 6 bp overlap

ZEB2 2 datasets

ChIP K-562 ENCSR004GKA.ZEB2.K-562 309 bp overlap

ChIP K562 ENCFF795CMH 398 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 367 bp overlap

ChIP HEK293 ENCFF033NQQ 269 bp overlap

ZKSCAN5 2 datasets

Motif DE_36h DE_36h-ZKSCAN5_MA1652.2 9 bp overlap

ChIP HEK293T GSE78099.ZKSCAN5.HEK293T 232 bp overlap

ZKSCAN8 1 dataset

ChIP K562 ENCFF387ETI 99 bp overlap

ZNF175 1 dataset

Motif DE_48h DE_48h-ZNF175_MA2332.1 9 bp overlap

ZNF257 1 dataset

Motif DE_36h DE_36h-ZNF257_MA1710.2 10 bp overlap

ZNF263 2 datasets

ChIP K-562 ENCSR000EWN.ZNF263.K-562 159 bp overlap

ChIP K562 ENCFF640RNA 517 bp overlap

ZNF558 1 dataset

ChIP HEK293T GSE78099.ZNF558.HEK293T 93 bp overlap

ZNF610 1 dataset

Motif DE_36h DE_36h-ZNF610_MA1713.2 10 bp overlap

ZNF691 1 dataset

ChIP HepG2 ENCFF427OHT 515 bp overlap

ZNF692 1 dataset

Motif DE_36h DE_36h-ZNF692_MA1986.2 8 bp overlap

ZNF740 1 dataset

ChIP K562 ENCFF913GVQ 174 bp overlap

ZNF75A 1 dataset

Motif DE_36h DE_36h-ZNF75A_MA2097.1 12 bp overlap

Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap