This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for KIFC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIFC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIFC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:57,600,258–57,600,842 | 246.0 kb | Distal (>10kb) Multiome | 438 | |
| chr16:57,630,443–57,631,059 | 215.9 kb | Distal (>10kb) Multiome | 129 | |
| chr16:57,734,819–57,736,404 | 111.0 kb | Distal (>10kb) Multiome | 885 | |
| chr16:57,757,066–57,757,860 | 89.1 kb | Distal (>10kb) Multiome | 470 | |
| chr16:57,774,953–57,776,466 | 70.7 kb | Distal (>10kb) Multiome | 273 | |
| chr16:57,801,721–57,803,781 | 44.0 kb | Distal (>10kb) Multiome | 918 | |
| chr16:57,846,136–57,846,734 | 17 bp | At TSS Multiome | 213 | |
| chr16:57,859,222–57,859,950 | 13.0 kb | Distal (>10kb) Multiome | 269 | |
| chr16:57,984,418–57,986,121 | 138.5 kb | Distal (>10kb) Multiome | 447 | |
| chr16:57,999,954–58,001,881 | 154.7 kb | Distal (>10kb) Multiome | 920 | |
| chr16:58,024,574–58,028,306 | 179.1 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:58,032,341–58,033,244 | 186.3 kb | Distal (>10kb) Multiome | 283 | |
| chr16:58,128,725–58,130,027 | 283.0 kb | Distal (>10kb) Multiome | 1095 |
Genomic view of the KIFC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.