This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for POLR2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:57,185,577–57,186,853 | 276.5 kb | Distal (>10kb) Multiome | 925 | |
| chr16:57,244,660–57,245,782 | 217.5 kb | Distal (>10kb) Multiome | 949 | |
| chr16:57,256,968–57,257,582 | 205.4 kb | Distal (>10kb) Multiome | 94 | |
| chr16:57,284,181–57,285,057 | 178.0 kb | Distal (>10kb) Multiome | 883 | |
| chr16:57,299,458–57,301,365 | 162.7 kb | Distal (>10kb) Multiome | 1112 | |
| chr16:57,416,668–57,417,660 | 45.5 kb | Distal (>10kb) Multiome | 597 | |
| chr16:57,427,202–57,428,139 | 35.0 kb | Distal (>10kb) Multiome | 105 | |
| chr16:57,446,894–57,447,991 | 15.2 kb | Distal (>10kb) Multiome | 958 | |
| chr16:57,462,496–57,462,948 | 34 bp | At TSS Multiome | 903 | |
| chr16:57,472,646–57,472,994 | 10.0 kb | Proximal (<10kb) | 202 | |
| chr16:57,475,764–57,476,257 | 13.4 kb | Distal (>10kb) Multiome | 391 | |
| chr16:57,485,922–57,486,831 | 23.8 kb | Distal (>10kb) Multiome | 527 | |
| chr16:57,528,258–57,529,545 | 66.0 kb | Distal (>10kb) Multiome | 230 | |
| chr16:57,535,588–57,536,986 | 73.5 kb | Distal (>10kb) Multiome | 726 | |
| chr16:57,600,258–57,600,842 | 137.9 kb | Distal (>10kb) Multiome | 438 | |
| chr16:57,630,443–57,631,059 | 168.0 kb | Distal (>10kb) Multiome | 129 | |
| chr16:57,734,819–57,736,404 | 272.9 kb | Distal (>10kb) Multiome | 885 | |
| chr16:57,757,066–57,757,860 | 294.7 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the POLR2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.