Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KATNB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KATNB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KATNB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:57,446,894–57,447,991 | 288.4 kb | Distal (>10kb) Multiome | 958 | |
| chr16:57,462,496–57,462,948 | 273.2 kb | Distal (>10kb) Multiome | 903 | |
| chr16:57,475,764–57,476,257 | 259.8 kb | Distal (>10kb) Multiome | 391 | |
| chr16:57,485,922–57,486,831 | 249.4 kb | Distal (>10kb) Multiome | 527 | |
| chr16:57,528,258–57,529,545 | 207.2 kb | Distal (>10kb) Multiome | 230 | |
| chr16:57,535,588–57,536,986 | 199.7 kb | Distal (>10kb) Multiome | 726 | |
| chr16:57,600,258–57,600,842 | 135.3 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr16:57,630,443–57,631,059 | 105.2 kb | Distal (>10kb) Multiome HiCAR | 129 | |
| chr16:57,734,819–57,736,404 | 314 bp | At TSS Multiome | 885 | |
| chr16:57,736,657–57,736,821 | 794 bp | At TSS | 359 | |
| chr16:57,757,066–57,757,860 | 21.5 kb | Distal (>10kb) Multiome | 470 | |
| chr16:57,774,953–57,776,466 | 40.0 kb | Distal (>10kb) Multiome | 273 | |
| chr16:57,801,721–57,803,781 | 66.6 kb | Distal (>10kb) Multiome | 918 | |
| chr16:57,846,136–57,846,734 | 110.7 kb | Distal (>10kb) Multiome | 213 | |
| chr16:57,859,222–57,859,950 | 123.7 kb | Distal (>10kb) Multiome | 269 | |
| chr16:57,984,418–57,986,121 | 249.2 kb | Distal (>10kb) Multiome | 447 | |
| chr16:57,999,954–58,001,881 | 265.4 kb | Distal (>10kb) Multiome | 920 | |
| chr16:58,024,574–58,028,306 | 289.7 kb | Distal (>10kb) Multiome | 1046 | |
| chr16:58,032,341–58,033,244 | 297.0 kb | Distal (>10kb) Multiome | 283 |
Genomic view of the KATNB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.