chr12:57,219,094–57,219,803

chr12 : 57,219,094 – 57,219,803

709 bp 71 TFs 9 linked genes

This 709 bp open chromatin element is linked to 9 target genes and is bound by 71 transcription factors.

Linked Genes

9 genes

Gene	Expression	Dist. to TSS	Distance	Link type
NXPH4		2.3 kb	Proximal	Proximity
SHMT2		9.9 kb	Proximal	Proximity
NDUFA4L2		17.6 kb	Distal	Multiome+HiCAR
LRP1		90.6 kb	Distal	Multiome
STAT6		108.1 kb	Distal	Multiome
NEMP1		140.7 kb	Distal	Multiome
R3HDM2		211.5 kb	Distal	Multiome
ZBTB39		212.9 kb	Distal	Multiome
MARS1		268.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

71 transcription factors

ChIP LNCaP_androgen-N_hypoxia-Y GSE114732.AR.LNCaP_androgen-N_hypoxia-Y 168 bp overlap

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 135 bp overlap

ARID2 1 dataset

ChIP Aska-SS GSE108025.ARID2.Aska-SS 395 bp overlap

ASCL1 1 dataset

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 224 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 369 bp overlap

ChIP H1 ENCFF399KAM 709 bp overlap

BCOR 2 datasets

ChIP WA01 GSE104690.BCOR.WA01 602 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 303 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 172 bp overlap

BRD4 8 datasets

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 352 bp overlap

ChIP CLL_patient2_4h_CpG_BET GSE109411.BRD4.CLL_patient2_4h_CpG_BET 367 bp overlap

ChIP CLL_patient3_4h_CpG_BET GSE109411.BRD4.CLL_patient3_4h_CpG_BET 220 bp overlap

ChIP LNCaP-C4-2_OE GSE88871.BRD4.LNCaP-C4-2_OE 253 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 538 bp overlap

ChIP retina_AB1-FW20 GSE86981.BRD4.retina_AB1-FW20 339 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 564 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 315 bp overlap

CBFA2T2 1 dataset

ChIP NCCIT GSE71675.CBFA2T2.NCCIT 553 bp overlap

ChIP hESC_TKO GSE133412.CBX7.hESC_TKO 303 bp overlap

CEBPD 1 dataset

ChIP Hep-G2 ENCSR000BQJ.CEBPD.Hep-G2 116 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 246 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 254 bp overlap

ChIP T-47D_Y537S GSE148277.CTCF.T-47D_Y537S 219 bp overlap

ChIP MCF-7 ENCSR017CEO.CUX1.MCF-7 316 bp overlap

DACH1 1 dataset

ChIP K-562 ENCSR030TJP.DACH1.K-562 201 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 139 bp overlap

EZH2 30 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 405 bp overlap

ChIP B cell ENCFF803EMO 227 bp overlap

ChIP B cell ENCFF803EMO 179 bp overlap

ChIP GM23338 ENCFF613YON 95 bp overlap

ChIP GM23338 ENCFF613YON 262 bp overlap

ChIP H1 ENCFF232NZA 709 bp overlap

ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 112 bp overlap

ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 128 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.EZH2.HUVEC-C_VEGF_12h 256 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.EZH2.HUVEC-C_VEGF_12h 89 bp overlap

ChIP HUVEC-C_VEGF_1h GSE109625.EZH2.HUVEC-C_VEGF_1h 126 bp overlap

ChIP HUVEC-C_VEGF_1h GSE109625.EZH2.HUVEC-C_VEGF_1h 262 bp overlap

ChIP Hep-3B2-1-7 GSE128137.EZH2.Hep-3B2-1-7 92 bp overlap

ChIP Hep-G2 ENCSR000ARI.EZH2.Hep-G2 234 bp overlap

ChIP Hep-G2 ENCSR000ARI.EZH2.Hep-G2 438 bp overlap

ChIP HepG2 ENCFF912EIW 496 bp overlap

ChIP HepG2 ENCFF912EIW 246 bp overlap

ChIP Karpas-422_DMSO-D8 GSE134136.EZH2.Karpas-422_DMSO-D8 104 bp overlap

ChIP astrocyte ENCFF365JTP 579 bp overlap

ChIP astrocyte ENCFF365JTP 65 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 398 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 404 bp overlap

ChIP fibroblast_LUNG ENCSR000ARO.EZH2.fibroblast_LUNG 292 bp overlap

ChIP hepatocyte ENCFF552DZB 301 bp overlap

ChIP keratinocyte ENCFF070STK 62 bp overlap

ChIP keratinocyte ENCFF070STK 318 bp overlap

ChIP keratinocyte ENCFF070STK 546 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 709 bp overlap

ChIP mammary epithelial cell ENCFF224GAI 75 bp overlap

ChIP neural progenitor cell ENCFF472NFV 621 bp overlap

EZH2_phosphoT487 2 datasets

ChIP hepatocyte ENCSR341VYI.EZH2_phosphoT487.hepatocyte 387 bp overlap

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 693 bp overlap

FOXA1 4 datasets

ChIP A1A3_EtOH GSE112491.FOXA1.A1A3_EtOH 59 bp overlap

ChIP VCaP_DHT24H GSE58428.FOXA1.VCaP_DHT24H 230 bp overlap

ChIP VCaP_ETOH24H GSE58428.FOXA1.VCaP_ETOH24H 324 bp overlap

ChIP primary-prostate-cancer_G2_DSG GSE114737.FOXA1.primary-prostate-cancer_G2_DSG 76 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-2 316 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-2 266 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 514 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 424 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 570 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 266 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 582 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 603 bp overlap

GLIS2 1 dataset

ChIP HEK293 ENCSR535DIA.GLIS2.HEK293 238 bp overlap

HEXIM1 1 dataset

ChIP HCT-116 GSE72622.HEXIM1.HCT-116 231 bp overlap

HIC1 3 datasets

ChIP HEK293 ENCFF252CFL 245 bp overlap

ChIP HEK293 ENCFF252CFL 441 bp overlap

ChIP HEK293 ENCSR803GYT.HIC1.HEK293 184 bp overlap

HIF3A 1 dataset

ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 164 bp overlap

IKZF3 2 datasets

ChIP HEK293 ENCFF518OXG 371 bp overlap

ChIP HEK293 ENCSR304AMN.IKZF3.HEK293 306 bp overlap

JARID2 4 datasets

ChIP AMIPS6 GSE48516.JARID2.AMIPS6 215 bp overlap

ChIP EDOMIPS2 GSE48516.JARID2.EDOMIPS2 598 bp overlap

ChIP UTEIPS6 GSE48516.JARID2.UTEIPS6 673 bp overlap

ChIP UTEIPS7 GSE48516.JARID2.UTEIPS7 476 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 373 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 302 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 432 bp overlap

KMT2A 1 dataset

ChIP RS4-11_DMSO-D3-180402 GSE127507.KMT2A.RS4-11_DMSO-D3-180402 288 bp overlap

ChIP CD4_Th1 GSE72266.MAF.CD4_Th1 269 bp overlap

MEF2D 2 datasets

ChIP retina_Hu21 GSE137311.MEF2D.retina_Hu21 217 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 237 bp overlap

ChIP DU145_SH4 GSE135623.MTF2.DU145_SH4 495 bp overlap

ChIP LNCaP_MYC GSE73994.MYC.LNCaP_MYC 110 bp overlap

ChIP LNCaP_DHT GSE117304.MYCN.LNCaP_DHT 130 bp overlap

NELFE 1 dataset

ChIP K-562_NHS GSE112379.NELFE.K-562_NHS 152 bp overlap

NEUROD1 2 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 509 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 340 bp overlap

NFKB1 1 dataset

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 216 bp overlap

NR3C1 1 dataset

ChIP breast_tumor_Male_21 GSE104399.NR3C1.breast_tumor_Male_21 132 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 227 bp overlap

POU2F1 3 datasets

ChIP T-47D GSE148277.POU2F1.T-47D 115 bp overlap

ChIP T-47D GSE148277.POU2F1.T-47D 191 bp overlap

ChIP T-47D_D538G GSE148277.POU2F1.T-47D_D538G 79 bp overlap

POU5F1 1 dataset

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 249 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 354 bp overlap

PRDM14 1 dataset

ChIP NCCIT GSE71675.PRDM14.NCCIT 449 bp overlap

RARA 2 datasets

ChIP hiPSC_D2 GSE132532.RARA.hiPSC_D2 374 bp overlap

ChIP hiPSC_D4 GSE109172.RARA.hiPSC_D4 179 bp overlap

ChIP HUES-64 GSE104059.RNF2.HUES-64 229 bp overlap

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 208 bp overlap

RYBP 2 datasets

ChIP WA01 GSE104690.RYBP.WA01 206 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 450 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 661 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 695 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 599 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 383 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 633 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 483 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 253 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 329 bp overlap

SMARCA4 5 datasets

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 139 bp overlap

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 344 bp overlap

ChIP Aska-SS_shSSX GSE108025.SMARCA4.Aska-SS_shSSX 224 bp overlap

ChIP NSC GSE125033.SMARCA4.NSC 156 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 64 bp overlap

SMARCC1 3 datasets

ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 397 bp overlap

ChIP Aska-SS_shSSX GSE108025.SMARCC1.Aska-SS_shSSX 149 bp overlap

ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 709 bp overlap

ChIP HEK293 ENCFF733RBE 54 bp overlap

ChIP Aska-SS GSE108025.SS18.Aska-SS 426 bp overlap

SUZ12 8 datasets

ChIP GM12878 ENCFF498QAM 371 bp overlap

ChIP GM12878 ENCSR744XTG.SUZ12.GM12878 235 bp overlap

ChIP GM12878 ENCSR744XTG.SUZ12.GM12878 210 bp overlap

ChIP H1 ENCFF881NFR 709 bp overlap

ChIP K-562 ENCSR000AUC.SUZ12.K-562 194 bp overlap

ChIP LNCaP-abl GSE39459.SUZ12.LNCaP-abl 154 bp overlap

ChIP NT2/D1 ENCFF574SXS 619 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 118 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 305 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 184 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 489 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 141 bp overlap

ZBTB8A 1 dataset

ChIP HEK293 ENCSR481FEC.ZBTB8A.HEK293 102 bp overlap

ChIP HEK293 ENCFF847JIE 130 bp overlap

ZFP69B 1 dataset

ChIP HEK293 ENCFF942LFP 173 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 309 bp overlap

ChIP HeLa-S3 ENCSR887MXT.ZHX1.HeLa-S3 64 bp overlap

ChIP HEK293 ENCFF641ICT 217 bp overlap

ZNF263 5 datasets

ChIP HEK293 ENCFF336CWQ 306 bp overlap

ChIP HEK293T GSE78099.ZNF263.HEK293T 169 bp overlap

ChIP K-562 ENCSR000EWN.ZNF263.K-562 179 bp overlap

ChIP K562 ENCFF640RNA 360 bp overlap

ChIP K562 ENCFF640RNA 521 bp overlap

ZNF283 1 dataset

ChIP HEK293T GSE78099.ZNF283.HEK293T 219 bp overlap

ZNF366 1 dataset

ChIP HEK293 ENCFF799ATK 165 bp overlap

ZNF394 3 datasets

ChIP HEK293 ENCFF236OPX 403 bp overlap

ChIP HEK293 ENCFF236OPX 201 bp overlap

ChIP HEK293 ENCSR125DNC.ZNF394.HEK293 428 bp overlap

ZNF398 1 dataset

ChIP HEK293 ENCSR676ZEF.ZNF398.HEK293 182 bp overlap

ZNF687 1 dataset

ChIP MCF-7 ENCSR899BKM.ZNF687.MCF-7 50 bp overlap

ZNF707 1 dataset

ChIP HEK293 ENCSR854IPI.ZNF707.HEK293 67 bp overlap

ZNF76 1 dataset

ChIP HEK293 ENCSR072LQF.ZNF76.HEK293 61 bp overlap