Involved in nuclear membrane organization. Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NEMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,006,056–57,006,942 | 72.2 kb | Distal (>10kb) Multiome | 422 | |
| chr12:57,069,529–57,069,740 | 9.0 kb | Proximal (<10kb) | 288 | |
| chr12:57,078,210–57,079,177 | 113 bp | At TSS Multiome | 778 | |
| chr12:57,086,367–57,089,469 | 10.1 kb | Distal (>10kb) Multiome | 1047 | |
| chr12:57,093,695–57,094,140 | 15.4 kb | Distal (>10kb) Multiome HiCAR | 243 | |
| chr12:57,110,045–57,111,598 | 31.7 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr12:57,111,611–57,112,633 | 33.6 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr12:57,127,277–57,129,227 | 49.4 kb | Distal (>10kb) Multiome | 725 | |
| chr12:57,214,315–57,214,722 | 135.8 kb | Distal (>10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 137.9 kb | Distal (>10kb) Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 140.7 kb | Distal (>10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 146.3 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 148.3 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 151.0 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 160.4 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 165.0 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 192.4 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 194.1 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 298.9 kb | Distal (>10kb) Multiome | 170 |
Genomic view of the NEMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.