This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for LRP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,006,056–57,006,942 | 122.4 kb | Distal (>10kb) Multiome | 422 | |
| chr12:57,078,210–57,079,177 | 50.0 kb | Distal (>10kb) Multiome | 778 | |
| chr12:57,086,367–57,089,469 | 40.0 kb | Distal (>10kb) Multiome | 1047 | |
| chr12:57,093,695–57,094,140 | 34.8 kb | Distal (>10kb) Multiome | 243 | |
| chr12:57,110,045–57,111,598 | 18.5 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr12:57,111,611–57,112,633 | 16.5 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr12:57,124,349–57,124,563 | 4.2 kb | Proximal (<10kb) | 210 | |
| chr12:57,127,277–57,129,227 | 778 bp | At TSS Multiome | 725 | |
| chr12:57,214,315–57,214,722 | 85.7 kb | Distal (>10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 87.8 kb | Distal (>10kb) Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 90.6 kb | Distal (>10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 96.1 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 98.2 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 100.9 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 110.3 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 114.9 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 142.2 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 143.9 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 248.8 kb | Distal (>10kb) Multiome | 170 |
Genomic view of the LRP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.