This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for HIC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:2,048,764–2,051,218 | 2.9 kb | Proximal (<10kb) | 658 | |
| chr17:2,053,643–2,054,179 | at TSS | At TSS | 473 | |
| chr17:2,054,616–2,055,766 | 463 bp | At TSS | 544 | |
| chr17:2,057,019–2,057,413 | 2.9 kb | Proximal (<10kb) | 98 | |
| chr17:2,058,401–2,059,503 | 4.2 kb | Proximal (<10kb) | 366 |
Genomic view of the HIC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.