Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NDUFA4L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFA4L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFA4L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,006,056–57,006,942 | 230.6 kb | Distal (>10kb) Multiome | 422 | |
| chr12:57,078,210–57,079,177 | 158.2 kb | Distal (>10kb) Multiome | 778 | |
| chr12:57,086,367–57,089,469 | 148.2 kb | Distal (>10kb) Multiome | 1047 | |
| chr12:57,110,045–57,111,598 | 126.7 kb | Distal (>10kb) Multiome | 656 | |
| chr12:57,111,611–57,112,633 | 124.7 kb | Distal (>10kb) Multiome | 940 | |
| chr12:57,127,277–57,129,227 | 109.0 kb | Distal (>10kb) Multiome | 725 | |
| chr12:57,214,315–57,214,722 | 22.5 kb | Distal (>10kb) Multiome HiCAR | 318 | |
| chr12:57,215,826–57,217,972 | 20.4 kb | Distal (>10kb) Multiome HiCAR | 525 | |
| chr12:57,219,094–57,219,803 | 17.6 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr12:57,224,526–57,225,152 | 12.1 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr12:57,225,987–57,227,617 | 10.0 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr12:57,229,358–57,230,407 | 7.3 kb | Proximal (<10kb) Multiome HiCAR | 739 | |
| chr12:57,234,986–57,235,550 | 1.6 kb | Proximal (<10kb) | 365 | |
| chr12:57,236,204–57,236,680 | 423 bp | At TSS | 133 | |
| chr12:57,237,027–57,237,584 | at TSS | At TSS | 93 | |
| chr12:57,237,805–57,241,749 | 2.1 kb | Proximal (<10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 6.7 kb | Proximal (<10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 34.0 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 35.7 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 140.6 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 193.9 kb | Distal (>10kb) Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 219.2 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 224.3 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 238.5 kb | Distal (>10kb) Multiome | 194 | |
| chr12:57,487,577–57,488,336 | 250.8 kb | Distal (>10kb) Multiome | 784 | |
| chr12:57,519,488–57,521,440 | 283.6 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:57,521,541–57,523,658 | 285.6 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the NDUFA4L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.