ZNF76

zinc finger protein 76 | ZNF523, Zfp523, D6S229E

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6

Biological processes 18 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)chromosome (GO:0005694)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase III (GO:0006359)regulation of transcription by RNA polymerase III (GO:0006359)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating ZNF76 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF76. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF76 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF76

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF76, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:35,141,228–35,141,736	118.1 kb	Distal (>10kb) Multiome	171
chr6:35,193,064–35,193,865	66.0 kb	Distal (>10kb) Multiome	107
chr6:35,213,536–35,214,675	45.4 kb	Distal (>10kb) Multiome	310
chr6:35,258,904–35,260,476	198 bp	At TSS Multiome	1142
chr6:35,297,619–35,298,109	38.3 kb	Distal (>10kb) Multiome	765
chr6:35,317,884–35,318,871	59.0 kb	Distal (>10kb) Multiome	727
chr6:35,342,126–35,343,068	83.0 kb	Distal (>10kb) Multiome	831
chr6:35,451,927–35,453,018	192.8 kb	Distal (>10kb) Multiome	799
chr6:35,467,935–35,469,331	208.8 kb	Distal (>10kb) Multiome	1091
chr6:35,485,138–35,486,890	226.9 kb	Distal (>10kb) Multiome	400
chr6:35,490,011–35,490,813	230.8 kb	Distal (>10kb) Multiome	310
chr6:35,495,972–35,498,486	237.6 kb	Distal (>10kb) Multiome	939
chr6:35,522,668–35,523,295	263.4 kb	Distal (>10kb) Multiome	419

Genome Browser

Genomic view of the ZNF76 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.