Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,724,695–56,725,713 | 281.2 kb | Distal (>10kb) Multiome | 972 | |
| chr12:56,751,814–56,752,566 | 254.3 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr12:57,001,512–57,001,726 | 4.8 kb | Proximal (<10kb) | 504 | |
| chr12:57,006,056–57,006,942 | 1 bp | At TSS Multiome | 422 | |
| chr12:57,016,368–57,016,692 | 9.8 kb | Proximal (<10kb) | 58 | |
| chr12:57,078,210–57,079,177 | 72.3 kb | Distal (>10kb) Multiome | 778 | |
| chr12:57,086,367–57,089,469 | 82.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr12:57,093,695–57,094,140 | 87.6 kb | Distal (>10kb) Multiome HiCAR | 243 | |
| chr12:57,110,045–57,111,598 | 103.9 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr12:57,111,611–57,112,633 | 105.8 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr12:57,127,277–57,129,227 | 121.6 kb | Distal (>10kb) Multiome | 725 | |
| chr12:57,214,315–57,214,722 | 208.0 kb | Distal (>10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 210.1 kb | Distal (>10kb) Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 212.9 kb | Distal (>10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 218.5 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 220.5 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 223.3 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 232.7 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 237.2 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 264.6 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 266.3 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the ZBTB39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.