MEF2D

myocyte enhancer factor 2D

This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Biological processes 28 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)adult heart development (GO:0007512)animal organ development (GO:0048513)cell differentiation (GO:0030154)chromatin (GO:0000785)histone deacetylase binding (GO:0042826)muscle organ development (GO:0007517)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of vascular associated smooth muscle cell proliferation (GO:1904707)protein binding (GO:0005515)protein dimerization activity (GO:0046983)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating MEF2D 0 TFs

Transcription factors with Perturb-seq knockdown data for MEF2D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEF2D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MEF2D

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEF2D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:156,212,611–156,213,686	287.6 kb	Distal (>10kb) Multiome	893
chr1:156,245,413–156,246,269	255.0 kb	Distal (>10kb) Multiome	380
chr1:156,282,165–156,283,323	217.9 kb	Distal (>10kb) Multiome	973
chr1:156,291,233–156,291,857	209.2 kb	Distal (>10kb) Multiome	518
chr1:156,337,825–156,339,056	162.3 kb	Distal (>10kb) Multiome	836
chr1:156,356,873–156,357,393	143.7 kb	Distal (>10kb) Multiome	506
chr1:156,368,893–156,369,552	131.6 kb	Distal (>10kb) Multiome	529
chr1:156,420,712–156,422,291	79.0 kb	Distal (>10kb) Multiome	569
chr1:156,429,277–156,430,847	70.9 kb	Distal (>10kb) Multiome	231
chr1:156,432,112–156,432,986	68.2 kb	Distal (>10kb) Multiome	50
chr1:156,439,076–156,440,265	60.8 kb	Distal (>10kb) Multiome	264
chr1:156,456,348–156,457,982	44.1 kb	Distal (>10kb) Multiome	1033
chr1:156,499,927–156,501,599	191 bp	At TSS Multiome	950
chr1:156,503,226–156,503,606	2.4 kb	Proximal (<10kb)	271
chr1:156,504,626–156,505,685	4.5 kb	Proximal (<10kb) Multiome	911
chr1:156,572,298–156,572,749	71.8 kb	Distal (>10kb) Multiome	580
chr1:156,583,883–156,584,356	83.3 kb	Distal (>10kb) Multiome	183
chr1:156,591,252–156,592,285	91.0 kb	Distal (>10kb) Multiome	706
chr1:156,601,188–156,601,796	100.7 kb	Distal (>10kb) Multiome	759
chr1:156,624,123–156,624,848	123.7 kb	Distal (>10kb) Multiome	472
chr1:156,641,772–156,642,623	141.3 kb	Distal (>10kb) Multiome	211
chr1:156,657,279–156,657,727	156.8 kb	Distal (>10kb) Multiome	357
chr1:156,659,788–156,660,816	159.4 kb	Distal (>10kb) Multiome	901
chr1:156,673,575–156,674,145	173.1 kb	Distal (>10kb) Multiome	269
chr1:156,676,488–156,677,779	176.6 kb	Distal (>10kb) Multiome	449
chr1:156,689,084–156,690,144	188.8 kb	Distal (>10kb) Multiome	508
chr1:156,692,653–156,693,825	192.4 kb	Distal (>10kb) Multiome	493
chr1:156,703,427–156,704,626	203.1 kb	Distal (>10kb) Multiome	182
chr1:156,704,839–156,707,238	205.4 kb	Distal (>10kb) Multiome	728
chr1:156,708,331–156,708,813	207.7 kb	Distal (>10kb) Multiome	108
chr1:156,728,152–156,729,282	227.9 kb	Distal (>10kb) Multiome	815
chr1:156,740,482–156,741,987	240.4 kb	Distal (>10kb) Multiome	1012
chr1:156,746,390–156,748,386	246.4 kb	Distal (>10kb) Multiome	750
chr1:156,751,012–156,752,594	251.1 kb	Distal (>10kb) Multiome	869
chr1:156,766,695–156,768,280	266.6 kb	Distal (>10kb) Multiome	967

Genome Browser

Genomic view of the MEF2D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.