Predicted to enable signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in GABA-ergic synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NXPH4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NXPH4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NXPH4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,006,056–57,006,942 | 210.2 kb | Distal (>10kb) Multiome | 422 | |
| chr12:57,078,210–57,079,177 | 137.9 kb | Distal (>10kb) Multiome | 778 | |
| chr12:57,086,367–57,089,469 | 127.9 kb | Distal (>10kb) Multiome | 1047 | |
| chr12:57,110,045–57,111,598 | 106.4 kb | Distal (>10kb) Multiome | 656 | |
| chr12:57,111,611–57,112,633 | 104.4 kb | Distal (>10kb) Multiome | 940 | |
| chr12:57,127,277–57,129,227 | 88.7 kb | Distal (>10kb) Multiome | 725 | |
| chr12:57,213,358–57,213,587 | 3.2 kb | Proximal (<10kb) | 312 | |
| chr12:57,214,315–57,214,722 | 2.2 kb | Proximal (<10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 104 bp | At TSS Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 2.7 kb | Proximal (<10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 8.2 kb | Proximal (<10kb) Multiome HiCAR | 267 | |
| chr12:57,225,987–57,227,617 | 10.3 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr12:57,229,358–57,230,407 | 13.0 kb | Distal (>10kb) Multiome HiCAR | 739 | |
| chr12:57,237,805–57,241,749 | 22.4 kb | Distal (>10kb) Multiome HiCAR | 846 | |
| chr12:57,242,371–57,244,402 | 27.0 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 54.3 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 56.0 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 160.9 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 214.2 kb | Distal (>10kb) Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 239.5 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 244.6 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 258.8 kb | Distal (>10kb) Multiome | 194 | |
| chr12:57,487,577–57,488,336 | 271.1 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the NXPH4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.