Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF283. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF283 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF283, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:41,883,883–41,884,651 | 1943.1 kb | Distal (>10kb) Multiome HiCAR | 917 | |
| chr19:41,887,651–41,888,254 | 1939.5 kb | Distal (>10kb) Multiome HiCAR | 553 | |
| chr19:43,526,489–43,527,639 | 300.2 kb | Distal (>10kb) Multiome | 712 | |
| chr19:43,532,595–43,534,553 | 293.3 kb | Distal (>10kb) Multiome | 698 | |
| chr19:43,575,342–43,576,244 | 251.8 kb | Distal (>10kb) Multiome | 562 | |
| chr19:43,580,271–43,581,020 | 246.8 kb | Distal (>10kb) Multiome | 151 | |
| chr19:43,594,710–43,596,874 | 231.1 kb | Distal (>10kb) Multiome | 998 | |
| chr19:43,618,905–43,620,391 | 207.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr19:43,639,490–43,640,467 | 187.5 kb | Distal (>10kb) Multiome | 545 | |
| chr19:43,667,574–43,669,430 | 158.8 kb | Distal (>10kb) Multiome | 787 | |
| chr19:43,671,889–43,672,687 | 155.2 kb | Distal (>10kb) Multiome | 162 | |
| chr19:43,673,253–43,674,111 | 153.6 kb | Distal (>10kb) Multiome | 55 | |
| chr19:43,754,239–43,755,900 | 72.7 kb | Distal (>10kb) Multiome | 899 | |
| chr19:43,773,845–43,774,908 | 52.9 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,798,557–43,799,046 | 28.6 kb | Distal (>10kb) Multiome | 403 | |
| chr19:43,827,133–43,827,702 | 88 bp | At TSS Multiome | 593 | |
| chr19:43,901,409–43,901,966 | 74.4 kb | Distal (>10kb) Multiome | 528 | |
| chr19:43,934,900–43,935,680 | 107.9 kb | Distal (>10kb) Multiome | 775 | |
| chr19:43,950,951–43,951,533 | 123.8 kb | Distal (>10kb) Multiome | 758 | |
| chr19:43,983,881–43,984,809 | 156.7 kb | Distal (>10kb) Multiome | 634 | |
| chr19:44,002,334–44,003,562 | 175.5 kb | Distal (>10kb) Multiome | 726 | |
| chr19:44,025,169–44,025,638 | 197.9 kb | Distal (>10kb) Multiome | 531 | |
| chr19:44,051,566–44,052,404 | 224.5 kb | Distal (>10kb) Multiome | 706 | |
| chr19:44,071,747–44,072,437 | 244.7 kb | Distal (>10kb) Multiome | 678 | |
| chr19:44,093,936–44,095,205 | 266.9 kb | Distal (>10kb) Multiome | 671 | |
| chr19:44,112,896–44,114,096 | 285.9 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the ZNF283 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.