chr8 : 133,039,954 – 133,040,830

876 bp 85 TFs 1 linked gene

This 876 bp open chromatin element is linked to SLA and is bound by 85 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
SLA		at TSS	At TSS	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

85 transcription factors

ARNTL 1 dataset

ChIP U2OS GSE44236.ARNTL.U2OS 238 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 478 bp overlap

ATF2 1 dataset

ChIP WA01 ENCSR000BQU.ATF2.WA01 257 bp overlap

Ahr::Arnt 2 datasets

Motif DE_12h DE_12h-AhrArnt_MA0006.2 5 bp overlap

Ascl2 1 dataset

Motif DE_12h DE_12h-Ascl2_MA0816.1 10 bp overlap

BCOR 1 dataset

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 167 bp overlap

BHLHE22 1 dataset

Motif DE_12h DE_12h-BHLHE22_MA1635.2 6 bp overlap

BRD2 1 dataset

ChIP MV4-11_IBET151_500nM GSE120715.BRD2.MV4-11_IBET151_500nM 155 bp overlap

BRD3 1 dataset

ChIP LPS141 GSE111253.BRD3.LPS141 213 bp overlap

BRD4 1 dataset

ChIP LPS141 GSE111253.BRD4.LPS141 199 bp overlap

Bhlha15 1 dataset

Motif DE_12h DE_12h-Bhlha15_MA1472.3 8 bp overlap

CHD8 1 dataset

ChIP T-47D_ETOH_45 GSE62428.CHD8.T-47D_ETOH_45 227 bp overlap

CRY1 1 dataset

ChIP U2OS GSE44236.CRY1.U2OS 130 bp overlap

CTCF 1 dataset

ChIP GM13976 ENCFF896BYT 161 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF031ISE 395 bp overlap

E2F6 3 datasets

ChIP H1 ENCFF785DWK 451 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 120 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 257 bp overlap

ERG 1 dataset

ChIP SKNO-1 GSE23730.ERG.SKNO-1 225 bp overlap

ESR1 7 datasets

ChIP Ishikawa_DMSO_D538G_clone3 GSE132426.ESR1.Ishikawa_DMSO_D538G_clone3 194 bp overlap

ChIP Ishikawa_E2-1h GSE129803.ESR1.Ishikawa_E2-1h 246 bp overlap

ChIP Ishikawa_ETV4-KO1_Mili GSE129803.ESR1.Ishikawa_ETV4-KO1_Mili 139 bp overlap

ChIP Ishikawa_siETV4-72h GSE129803.ESR1.Ishikawa_siETV4-72h 222 bp overlap

ChIP MCF-7_E2_45m GSE67295.ESR1.MCF-7_E2_45m 184 bp overlap

ChIP MCF-7_Veh_OA GSE93510.ESR1.MCF-7_Veh_OA 164 bp overlap

ChIP MCF-7_aldosterone GSE99626.ESR1.MCF-7_aldosterone 245 bp overlap

EZH1 1 dataset

ChIP ProEs GSE59087.EZH1.ProEs 156 bp overlap

EZH2 4 datasets

ChIP Hep-3B2-1-7 GSE128137.EZH2.Hep-3B2-1-7 529 bp overlap

ChIP Hep-3B2-1-7 GSE128137.EZH2.Hep-3B2-1-7 194 bp overlap

ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 342 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 273 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 354 bp overlap

ChIP DE DE-GATA4-2 327 bp overlap

GATA6 6 datasets

ChIP DE DE-GATA6-1 315 bp overlap

ChIP DE DE-GATA6-2 316 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 324 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 462 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 400 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 391 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 183 bp overlap

GSPT2 1 dataset

ChIP HEK293T GSE35197.GSPT2.HEK293T 183 bp overlap

HES1 1 dataset

Motif DE_12h DE_12h-HES1_MA1099.3 8 bp overlap

HEXIM1 1 dataset

ChIP HCT-116 GSE72622.HEXIM1.HCT-116 239 bp overlap

HIF3A 1 dataset

ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 237 bp overlap

HIVEP1 1 dataset

ChIP Hep-G2 ENCSR697WMX.HIVEP1.Hep-G2 198 bp overlap

HNF4A 1 dataset

ChIP Caco-2_DIFF GSE23436.HNF4A.Caco-2_DIFF 129 bp overlap

ISL2 1 dataset

Motif DE_12h DE_12h-ISL2_MA0914.2 6 bp overlap

JUN 1 dataset

ChIP HUES-8 GSE109524.JUN.HUES-8 352 bp overlap

JUNB 1 dataset

ChIP Karpas-299 GSE151413.JUNB.Karpas-299 460 bp overlap

MAFF 1 dataset

Motif DE_12h DE_12h-MAFF_MA0495.4 11 bp overlap

MAX 1 dataset

ChIP H1 ENCFF914VQY 357 bp overlap

MCM3 1 dataset

ChIP K-562 ENCSR990AZC.MCM3.K-562 220 bp overlap

MCM5 2 datasets

ChIP K-562 ENCSR628APV.MCM5.K-562 216 bp overlap

ChIP K-562 ENCSR628APV.MCM5.K-562 316 bp overlap

MEIS1 1 dataset

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

MGA::EVX1 1 dataset

Motif DE_12h DE_12h-MGAEVX1_MA1960.2 11 bp overlap

MLLT1 1 dataset

ChIP K-562 ENCSR675LRO.MLLT1.K-562 206 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 293 bp overlap

MSC 1 dataset

Motif DE_12h DE_12h-MSC_MA0665.1 10 bp overlap

MYF5 1 dataset

Motif DE_12h DE_12h-MYF5_MA1641.2 8 bp overlap

MYOD1 3 datasets

Motif DE_12h DE_12h-MYOD1_MA0499.3 9 bp overlap

ChIP IMR-90_GM GSE128527.MYOD1.IMR-90_GM 254 bp overlap

ChIP RD GSE137168.MYOD1.RD 218 bp overlap

NANOG 4 datasets

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 502 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 243 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 350 bp overlap

NCOA3 1 dataset

ChIP MCF-7_E2 ERP000901.NCOA3.MCF-7_E2 107 bp overlap

NEUROD1 1 dataset

Motif DE_12h DE_12h-NEUROD1_MA1109.2 8 bp overlap

NR3C1 1 dataset

ChIP A-549 ENCSR000BJR.NR3C1.A-549 147 bp overlap

Neurod2 2 datasets

Motif DE_12h DE_12h-Neurod2_MA0668.3 8 bp overlap

Motif DE_12h DE_12h-Neurod2_MA1993.2 6 bp overlap

Olig2 1 dataset

Motif DE_12h DE_12h-Olig2_MA1997.2 6 bp overlap

PAX5 1 dataset

Motif DE_12h DE_12h-PAX5_MA0014.4 8 bp overlap

PDX1 1 dataset

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 364 bp overlap

PKNOX1 1 dataset

ChIP MCF-7 ENCSR986XYK.PKNOX1.MCF-7 142 bp overlap

POLR2A 5 datasets

ChIP spleen ENCFF044PYR 242 bp overlap

ChIP spleen ENCFF446ZGT 367 bp overlap

ChIP spleen ENCFF706IUS 406 bp overlap

ChIP thyroid gland ENCFF979LRR 220 bp overlap

ChIP thyroid gland ENCFF979LRR 411 bp overlap

POU5F1 2 datasets

ChIP BG03 GSE21614.POU5F1.BG03 307 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 362 bp overlap

Ptf1A 1 dataset

Motif DE_12h DE_12h-Ptf1A_MA1619.2 8 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 159 bp overlap

RELA 1 dataset

ChIP MCF-7_IL1b_45m GSE67295.RELA.MCF-7_IL1b_45m 144 bp overlap

RUNX1T1 1 dataset

ChIP Kasumi-1_E2 GSE102697.RUNX1T1.Kasumi-1_E2 153 bp overlap

SCRT1 2 datasets

ChIP HEK293 ENCFF513YVP 417 bp overlap

ChIP HEK293 ENCSR605MGM.SCRT1.HEK293 425 bp overlap

SCRT2 1 dataset

ChIP HEK293 ENCFF711QQB 521 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 311 bp overlap

SMAD2_3 3 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 249 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 430 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 264 bp overlap

SMARCA4 1 dataset

ChIP K-562 ENCSR643VTW.SMARCA4.K-562 230 bp overlap

SNAI2 1 dataset

ChIP RD GSE137168.SNAI2.RD 317 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 484 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 269 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 259 bp overlap

TAL1::TCF3 1 dataset

Motif DE_12h DE_12h-TAL1TCF3_MA0091.2 10 bp overlap

TCF12 2 datasets

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 221 bp overlap

TCFL5 1 dataset

Motif DE_12h DE_12h-TCFL5_MA0632.3 8 bp overlap

TEAD1 2 datasets

ChIP WTC11 ENCFF502QUV 405 bp overlap

ChIP WTC11 ENCFF502QUV 252 bp overlap

TFAP4 1 dataset

Motif DE_12h DE_12h-TFAP4_MA0691.1 10 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_12h DE_12h-TFAP4FLI1_MA1967.2 14 bp overlap

THAP1 1 dataset

Motif DE_12h DE_12h-THAP1_MA0597.3 8 bp overlap

Tcf12 1 dataset

Motif DE_12h DE_12h-Tcf12_MA0521.3 6 bp overlap

Tcf21 1 dataset

Motif DE_12h DE_12h-Tcf21_MA0832.2 10 bp overlap

Twist2 1 dataset

Motif DE_12h DE_12h-Twist2_MA0633.3 6 bp overlap

ZBTB18 1 dataset

Motif DE_12h DE_12h-ZBTB18_MA0698.2 11 bp overlap

ZBTB48 1 dataset

ChIP U2OS_ZBTB48-KO GSE96776.ZBTB48.U2OS_ZBTB48-KO 338 bp overlap

ZEB1 1 dataset

ChIP neuron_bipolar_doxy_4d ENCSR418KUS.ZEB1.neuron_bipolar_doxy_4d 205 bp overlap

ZNF366 1 dataset

ChIP HEK293 ENCSR106EBH.ZNF366.HEK293 233 bp overlap

ZNF512 2 datasets

ChIP K-562 ENCSR591CCL.ZNF512.K-562 201 bp overlap

ChIP K562 ENCFF601EMZ 387 bp overlap

ZNF512B 1 dataset

ChIP MCF-7 ENCSR761LRR.ZNF512B.MCF-7 170 bp overlap

ZNF768 1 dataset

Motif DE_12h DE_12h-ZNF768_MA1731.2 9 bp overlap

ZNF865 1 dataset

ChIP HepG2 ENCFF472KAQ 220 bp overlap