This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of transcription. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for ZNF512. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF512 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF512, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:27,306,488–27,307,261 | 276.4 kb | Distal (>10kb) Multiome | 115 | |
| chr2:27,322,773–27,323,423 | 259.9 kb | Distal (>10kb) Multiome | 906 | |
| chr2:27,356,094–27,357,596 | 226.1 kb | Distal (>10kb) Multiome | 1084 | |
| chr2:27,369,685–27,371,261 | 212.6 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:27,380,026–27,381,202 | 202.3 kb | Distal (>10kb) Multiome | 821 | |
| chr2:27,408,972–27,410,056 | 173.4 kb | Distal (>10kb) Multiome | 989 | |
| chr2:27,428,202–27,429,633 | 154.4 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:27,441,811–27,442,884 | 140.6 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,489,334–27,490,205 | 93.2 kb | Distal (>10kb) Multiome | 731 | |
| chr2:27,494,797–27,495,577 | 87.8 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,517,085–27,517,958 | 65.5 kb | Distal (>10kb) Multiome | 130 | |
| chr2:27,572,967–27,573,319 | 9.7 kb | Proximal (<10kb) | 17 | |
| chr2:27,582,572–27,583,317 | 91 bp | At TSS Multiome | 843 | |
| chr2:27,628,534–27,629,380 | 46.0 kb | Distal (>10kb) Multiome | 828 | |
| chr2:27,663,338–27,664,216 | 80.7 kb | Distal (>10kb) Multiome | 1035 | |
| chr2:27,681,105–27,682,049 | 98.6 kb | Distal (>10kb) Multiome | 85 | |
| chr2:27,715,293–27,715,981 | 132.9 kb | Distal (>10kb) Multiome | 346 | |
| chr2:27,735,279–27,736,049 | 152.6 kb | Distal (>10kb) Multiome | 395 | |
| chr2:27,752,465–27,753,359 | 169.8 kb | Distal (>10kb) Multiome | 577 | |
| chr2:27,771,346–27,772,271 | 188.7 kb | Distal (>10kb) Multiome | 941 |
Genomic view of the ZNF512 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.