The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MCM5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCM5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCM5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:35,134,690–35,135,283 | 265.3 kb | Distal (>10kb) Multiome | 87 | |
| chr22:35,257,329–35,258,076 | 142.6 kb | Distal (>10kb) Multiome | 851 | |
| chr22:35,299,271–35,300,787 | 100.2 kb | Distal (>10kb) Multiome | 908 | |
| chr22:35,350,767–35,351,264 | 49.2 kb | Distal (>10kb) Multiome | 589 | |
| chr22:35,371,784–35,372,565 | 28.1 kb | Distal (>10kb) Multiome | 874 | |
| chr22:35,376,743–35,377,378 | 23.1 kb | Distal (>10kb) Multiome | 810 | |
| chr22:35,399,845–35,400,552 | 95 bp | At TSS Multiome | 740 | |
| chr22:35,539,918–35,540,941 | 140.3 kb | Distal (>10kb) Multiome | 411 | |
| chr22:35,627,232–35,627,966 | 227.4 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the MCM5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.