This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for GSPT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSPT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSPT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:51,496,289–51,497,240 | 246.7 kb | Distal (>10kb) Multiome | 219 | |
| chrX:51,743,291–51,743,892 | at TSS | At TSS | 284 | |
| chrX:51,802,904–51,803,632 | 59.9 kb | Distal (>10kb) Multiome | 337 | |
| chrX:51,893,033–51,893,969 | 150.0 kb | Distal (>10kb) Multiome | 381 | |
| chrX:51,922,459–51,922,905 | 179.2 kb | Distal (>10kb) Multiome | 110 |
Genomic view of the GSPT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.