chr4 : 121,765,909 – 121,766,426

517 bp 86 TFs 1 linked gene

This 517 bp open chromatin element is linked to SMIM43 and is bound by 86 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
SMIM43		548 bp	At TSS	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

86 transcription factors

ARNT2 1 dataset

Motif DE_12h DE_12h-ARNT2_MA1464.2 8 bp overlap

ARNT::HIF1A 1 dataset

Motif DE_12h DE_12h-ARNTHIF1A_MA0259.2 5 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 429 bp overlap

Arnt 1 dataset

Motif DE_12h DE_12h-Arnt_MA0004.1 6 bp overlap

Arntl 1 dataset

Motif DE_12h DE_12h-Arntl_MA0603.2 8 bp overlap

BACH2 1 dataset

Motif DE_12h DE_12h-BACH2_MA1101.3 11 bp overlap

BHLHE22 1 dataset

Motif DE_12h DE_12h-BHLHE22_MA1635.2 6 bp overlap

BHLHE40 6 datasets

Motif DE_12h DE_12h-BHLHE40_MA0464.3 8 bp overlap

ChIP GM12878 ENCFF521IZR 299 bp overlap

ChIP GM12878 ENCSR987MTA.BHLHE40.GM12878 207 bp overlap

ChIP Hep-G2 ENCSR000EDT.BHLHE40.Hep-G2 128 bp overlap

ChIP K-562 ENCSR000EGV.BHLHE40.K-562 164 bp overlap

ChIP K562 ENCFF923NJI 269 bp overlap

BHLHE41 1 dataset

Motif DE_12h DE_12h-BHLHE41_MA0636.1 10 bp overlap

BRD1 1 dataset

ChIP HUES-64 GSE104059.BRD1.HUES-64 344 bp overlap

BRD4 1 dataset

ChIP HEK293_sgNT GSE129407.BRD4.HEK293_sgNT 216 bp overlap

BRF1 1 dataset

ChIP H9 GSE94418.BRF1.H9 136 bp overlap

CBX8 1 dataset

ChIP K-562 ENCSR000ATW.CBX8.K-562 351 bp overlap

CTCF 1 dataset

ChIP hiPSC_CVI GSE106870.CTCF.hiPSC_CVI 126 bp overlap

Cebpa 3 datasets

ChIP BLaER1 ENCFF031ISE 302 bp overlap

ChIP BLaER1 ENCFF274GAT 298 bp overlap

ChIP BLaER1 ENCFF364PUR 277 bp overlap

E2F6 2 datasets

ChIP K-562 ENCSR000BLI.E2F6.K-562 117 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 127 bp overlap

EED 1 dataset

ChIP ProEs GSE59087.EED.ProEs 168 bp overlap

EHF 1 dataset

Motif DE_12h DE_12h-EHF_MA0598.4 9 bp overlap

ELF1 1 dataset

Motif DE_12h DE_12h-ELF1_MA0473.4 9 bp overlap

ESR2 1 dataset

Motif DE_12h DE_12h-ESR2_MA0258.2 15 bp overlap

EZH2 3 datasets

ChIP H1 ENCFF232NZA 281 bp overlap

ChIP hepatocyte ENCFF552DZB 70 bp overlap

ChIP hepatocyte ENCFF552DZB 273 bp overlap

FOS 1 dataset

Motif DE_12h DE_12h-FOS_MA0476.2 8 bp overlap

FOS::JUNB 1 dataset

Motif DE_12h DE_12h-FOSJUNB_MA1134.2 9 bp overlap

FOSB::JUNB 1 dataset

Motif DE_12h DE_12h-FOSBJUNB_MA1135.2 9 bp overlap

FOSL2::JUNB 1 dataset

Motif DE_12h DE_12h-FOSL2JUNB_MA1138.2 9 bp overlap

FOSL2::JUND 1 dataset

Motif DE_12h DE_12h-FOSL2JUND_MA1144.2 9 bp overlap

GATA6 1 dataset

ChIP AGS GSE51936.GATA6.AGS 103 bp overlap

HAND2 1 dataset

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

HES1 1 dataset

Motif DE_12h DE_12h-HES1_MA1099.3 8 bp overlap

HES2 1 dataset

Motif DE_12h DE_12h-HES2_MA0616.3 9 bp overlap

HES5 1 dataset

Motif DE_12h DE_12h-HES5_MA0821.2 10 bp overlap

HES6 1 dataset

Motif DE_12h DE_12h-HES6_MA1493.1 10 bp overlap

HES7 1 dataset

Motif DE_12h DE_12h-HES7_MA0822.1 12 bp overlap

HEY1 1 dataset

Motif DE_12h DE_12h-HEY1_MA0823.1 10 bp overlap

HEY2 1 dataset

Motif DE_12h DE_12h-HEY2_MA0649.2 9 bp overlap

HIF1A 1 dataset

Motif DE_12h DE_12h-HIF1A_MA1106.2 6 bp overlap

HNF4A 1 dataset

ChIP Hep-G2 ENCSR469FBY.HNF4A.Hep-G2 143 bp overlap

JARID2 4 datasets

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 517 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 438 bp overlap

ChIP UTEIPS6 GSE48516.JARID2.UTEIPS6 168 bp overlap

ChIP UTEIPS7 GSE48516.JARID2.UTEIPS7 357 bp overlap

JUND 1 dataset

Motif DE_12h DE_12h-JUND_MA0491.3 9 bp overlap

MAX 1 dataset

Motif DE_12h DE_12h-MAX_MA0058.4 6 bp overlap

MEIS1 1 dataset

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

MITF 3 datasets

Motif DE_12h DE_12h-MITF_MA0620.4 10 bp overlap

ChIP K-562 ENCSR797SWM.MITF.K-562 283 bp overlap

ChIP K562 ENCFF731XJJ 156 bp overlap

MLX 1 dataset

Motif DE_12h DE_12h-MLX_MA0663.1 10 bp overlap

MLXIPL 1 dataset

Motif DE_12h DE_12h-MLXIPL_MA0664.2 8 bp overlap

MNT 1 dataset

Motif DE_12h DE_12h-MNT_MA0825.2 6 bp overlap

Mlxip 1 dataset

Motif DE_12h DE_12h-Mlxip_MA0622.2 6 bp overlap

NEUROG2 1 dataset

Motif DE_12h DE_12h-NEUROG2_MA1642.2 7 bp overlap

NR2C1 1 dataset

Motif DE_12h DE_12h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_12h DE_12h-NR2C2_MA1536.2 6 bp overlap

NUTM1 1 dataset

ChIP embryonic-kidney_induced GSE133122.NUTM1.embryonic-kidney_induced 221 bp overlap

Neurod2 1 dataset

Motif DE_12h DE_12h-Neurod2_MA1993.2 6 bp overlap

Nr1H2 1 dataset

Motif DE_12h DE_12h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_12h DE_12h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_12h DE_12h-Nr1h3_MA2337.1 6 bp overlap

Olig2 1 dataset

Motif DE_12h DE_12h-Olig2_MA1997.2 6 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 232 bp overlap

PHF19 1 dataset

ChIP DU145_SH4 GSE135623.PHF19.DU145_SH4 252 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 121 bp overlap

RAD51 2 datasets

ChIP K-562 ENCSR524BUE.RAD51.K-562 263 bp overlap

ChIP K562 ENCFF133ELP 305 bp overlap

RELA 1 dataset

ChIP 786-O GSE86092.RELA.786-O 181 bp overlap

RNF2 3 datasets

ChIP K-562 ENCSR820GND.RNF2.K-562 217 bp overlap

ChIP K-562 ENCSR138FUZ.RNF2.K-562 57 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 342 bp overlap

SIX1 1 dataset

Motif DE_12h DE_12h-SIX1_MA1118.2 9 bp overlap

SMARCA4 1 dataset

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 148 bp overlap

SNAI2 1 dataset

ChIP SMS-CTR_D48 GSE137168.SNAI2.SMS-CTR_D48 253 bp overlap

SOHLH2 1 dataset

Motif DE_12h DE_12h-SOHLH2_MA1560.2 8 bp overlap

SUZ12 1 dataset

ChIP H1 ENCFF881NFR 187 bp overlap

TCF3 1 dataset

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

TCFL5 1 dataset

Motif DE_12h DE_12h-TCFL5_MA0632.3 8 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_12h DE_12h-TFAP4FLI1_MA1967.2 14 bp overlap

TFE3 1 dataset

Motif DE_12h DE_12h-TFE3_MA0831.3 10 bp overlap

TFEB 1 dataset

Motif DE_12h DE_12h-TFEB_MA0692.2 8 bp overlap

TFEC 1 dataset

Motif DE_12h DE_12h-TFEC_MA0871.3 8 bp overlap

Tcf12 1 dataset

Motif DE_12h DE_12h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_12h DE_12h-Twist2_MA0633.3 6 bp overlap

USF1 8 datasets

Motif DE_12h DE_12h-USF1_MA0093.4 10 bp overlap

ChIP H1 ENCFF090WVU 77 bp overlap

ChIP Hep-G2 ENCSR000BGM.USF1.Hep-G2 146 bp overlap

ChIP HepG2 ENCFF201JKA 276 bp overlap

ChIP HepG2 ENCFF807KYJ 199 bp overlap

ChIP K-562 ENCSR000BKT.USF1.K-562 213 bp overlap

ChIP K562 ENCFF633EZB 205 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 218 bp overlap

USF2 8 datasets

Motif DE_12h DE_12h-USF2_MA0526.5 10 bp overlap

ChIP H1 ENCFF434EDF 226 bp overlap

ChIP Hep-G2 GSE97661.USF2.Hep-G2 140 bp overlap

ChIP K-562 ENCSR578KEN.USF2.K-562 162 bp overlap

ChIP K562 ENCFF306QPU 371 bp overlap

ChIP K562 ENCFF397QGU 238 bp overlap

ChIP WA01 ENCSR000ECD.USF2.WA01 144 bp overlap

ChIP WTC11 ENCFF139JAW 281 bp overlap

ZBTB11 1 dataset

Motif DE_12h DE_12h-ZBTB11_MA2329.1 9 bp overlap

ZBTB33 1 dataset

ChIP K562 ENCFF427SDV 359 bp overlap

ZFP14 1 dataset

Motif DE_12h DE_12h-ZFP14_MA1972.1 15 bp overlap

ZFP36 1 dataset

ChIP K-562 ENCSR776CYN.ZFP36.K-562 50 bp overlap

ZKSCAN3 1 dataset

Motif DE_12h DE_12h-ZKSCAN3_MA1973.2 14 bp overlap

ZNF135 1 dataset

Motif DE_12h DE_12h-ZNF135_MA1587.1 14 bp overlap

ZNF16 1 dataset

Motif DE_12h DE_12h-ZNF16_MA1654.2 21 bp overlap

ZNF263 2 datasets

ChIP Hep-G2 ENCSR313MMD.ZNF263.Hep-G2 227 bp overlap

ChIP WTC11 ENCFF893RTM 437 bp overlap

ZNF354C 1 dataset

Motif DE_12h DE_12h-ZNF354C_MA0130.1 6 bp overlap

ZSCAN16 1 dataset

Motif DE_12h DE_12h-ZSCAN16_MA2100.1 18 bp overlap