HES5
hes family bHLH transcription factor 5 | bHLHb38

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

Biological processes 68 terms
DNA binding (GO:0003677)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)Notch signaling pathway (GO:0007219)Notch signaling pathway (GO:0007219)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)S-shaped body morphogenesis (GO:0072050)animal organ development (GO:0048513)anterior/posterior pattern specification (GO:0009952)astrocyte differentiation (GO:0048708)astrocyte differentiation (GO:0048708)brain development (GO:0007420)brain development (GO:0007420)camera-type eye development (GO:0043010)camera-type eye development (GO:0043010)cartilage development (GO:0051216)cartilage development (GO:0051216)cell adhesion (GO:0007155)cell maturation (GO:0048469)central nervous system myelination (GO:0022010)chondrocyte differentiation (GO:0002062)chromatin (GO:0000785)comma-shaped body morphogenesis (GO:0072049)glial cell fate commitment (GO:0021781)metanephric nephron tubule morphogenesis (GO:0072282)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of astrocyte differentiation (GO:0048712)negative regulation of astrocyte differentiation (GO:0048712)negative regulation of cell differentiation (GO:0045596)negative regulation of inner ear receptor cell differentiation (GO:2000981)negative regulation of neuron differentiation (GO:0045665)negative regulation of oligodendrocyte differentiation (GO:0048715)negative regulation of oligodendrocyte differentiation (GO:0048715)negative regulation of pro-B cell differentiation (GO:2000974)negative regulation of stem cell differentiation (GO:2000737)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)neural tube development (GO:0021915)neuron differentiation (GO:0030182)neuronal stem cell population maintenance (GO:0097150)neuronal stem cell population maintenance (GO:0097150)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)oligodendrocyte development (GO:0014003)positive regulation of BMP signaling pathway (GO:0030513)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of Notch signaling pathway (GO:0045747)positive regulation of cell population proliferation (GO:0008284)positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427)positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427)positive regulation of smooth muscle cell proliferation (GO:0048661)protein dimerization activity (GO:0046983)protein-containing complex assembly (GO:0065003)protein-containing complex assembly (GO:0065003)regulation of DNA-templated transcription (GO:0006355)regulation of cell differentiation (GO:0045595)regulation of myelination (GO:0031641)regulation of neurogenesis (GO:0050767)regulation of neurogenesis (GO:0050767)sequence-specific double-stranded DNA binding (GO:1990837)smoothened signaling pathway (GO:0007224)specification of loop of Henle identity (GO:0072086)system development (GO:0048731)telencephalon development (GO:0021537)
Expression (TPM)
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