chr3:10,226,242–10,226,711

chr3 : 10,226,242 – 10,226,711

469 bp 88 TFs 12 linked genes

This 469 bp open chromatin element is linked to 12 target genes and is bound by 88 transcription factors.

Linked Genes

12 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TATDN2		21.9 kb	Distal	Multiome
GHRLOS		59.2 kb	Distal	Multiome
IRAK2		61.6 kb	Distal	Multiome
VHL		84.7 kb	Distal	Multiome+HiCAR
SEC13		94.6 kb	Distal	Multiome
BRK1		110.9 kb	Distal	Multiome
FANCD2		200.1 kb	Distal	Multiome
ENSG00000291078		200.2 kb	Distal	Multiome
ENSG00000291224		239.6 kb	Distal	Multiome
EMC3		239.7 kb	Distal	Multiome
PRRT3		279.5 kb	Distal	Multiome
CRELD1		292.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

88 transcription factors

ASCL1 2 datasets

Motif DE_12h DE_12h-ASCL1_MA1631.2 9 bp overlap

Motif ES_0h ES_0h-ASCL1_MA1631.2 9 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 338 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 469 bp overlap

BCL6 5 datasets

ChIP B-cell_GERMINAL_CENTER GSE68349.BCL6.B-cell_GERMINAL_CENTER 421 bp overlap

ChIP B-cell_GERMINAL_CENTER GSE43350.BCL6.B-cell_GERMINAL_CENTER 322 bp overlap

ChIP OCI-Ly1 GSE29282.BCL6.OCI-Ly1 425 bp overlap

ChIP OCI-Ly1 GSE107920.BCL6.OCI-Ly1 136 bp overlap

ChIP SU-DHL-4 GSE119038.BCL6.SU-DHL-4 429 bp overlap

BCL6B 2 datasets

Motif DE_12h DE_12h-BCL6B_MA0731.1 17 bp overlap

Motif ES_0h ES_0h-BCL6B_MA0731.1 17 bp overlap

BCOR 3 datasets

ChIP B-cell_GERMINAL_CENTER GSE43350.BCOR.B-cell_GERMINAL_CENTER 407 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 121 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 317 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD3.MV4-11_IBET151_50nM 189 bp overlap

BRD4 4 datasets

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 275 bp overlap

ChIP CLL_patient3 GSE109411.BRD4.CLL_patient3 305 bp overlap

ChIP hESC GSE33281.BRD4.hESC 61 bp overlap

ChIP hESC GSE33281.BRD4.hESC 65 bp overlap

ChIP H9 GSE94418.BRF1.H9 171 bp overlap

CHD1 2 datasets

ChIP WA01 ENCSR000AQK.CHD1.WA01 87 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 203 bp overlap

CHD7 2 datasets

ChIP H1 ENCFF126NLU 469 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 253 bp overlap

CREB1 1 dataset

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 343 bp overlap

CREBBP 2 datasets

ChIP tonsil_GCBC_p5 GSE89688.CREBBP.tonsil_GCBC_p5 420 bp overlap

ChIP tonsil_GCBc_p4 GSE89688.CREBBP.tonsil_GCBc_p4 447 bp overlap

CTCF 3 datasets

ChIP DOHH2 ENCSR084RDK.CTCF.DOHH2 254 bp overlap

ChIP HCT-116 GSE131606.CTCF.HCT-116 263 bp overlap

ChIP esophagus_muscularis-mucosa ENCSR353DFU.CTCF.esophagus_muscularis-mucosa 149 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF346MCV 251 bp overlap

ChIP BLaER1 ENCFF460KDD 351 bp overlap

ChIP MUTUL GSE75503.EBF1.MUTUL 234 bp overlap

EP300 1 dataset

ChIP WA01 ENCSR000BKK.EP300.WA01 151 bp overlap

ChIP VCaP_E2_ERA GSE43985.ESR1.VCaP_E2_ERA 142 bp overlap

FIGLA 2 datasets

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

Motif ES_0h ES_0h-FIGLA_MA0820.2 6 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 310 bp overlap

HNRNPH1 1 dataset

ChIP Hep-G2 ENCSR066FXN.HNRNPH1.Hep-G2 162 bp overlap

ChIP Karpas-299 GSE151413.JUN.Karpas-299 162 bp overlap

KDM1A 1 dataset

ChIP NCI-H526_DMSO GSE66297.KDM1A.NCI-H526_DMSO 370 bp overlap

ChIP OCI-Ly7 GSE47784.MAFK.OCI-Ly7 289 bp overlap

ChIP H1 ENCFF914VQY 284 bp overlap

ChIP P493-6 GSE42262.MAX.P493-6 196 bp overlap

MEF2B 1 dataset

ChIP tonsil GSE110682.MEF2B.tonsil 468 bp overlap

MXI1 2 datasets

Motif DE_12h DE_12h-MXI1_MA1108.3 6 bp overlap

Motif ES_0h ES_0h-MXI1_MA1108.3 6 bp overlap

MYOD1 1 dataset

ChIP RH4 GSE83726.MYOD1.RH4 170 bp overlap

MZF1 4 datasets

Motif DE_12h DE_12h-MZF1_MA0056.3 8 bp overlap

Motif DE_12h DE_12h-MZF1_MA0056.3 8 bp overlap

Motif ES_0h ES_0h-MZF1_MA0056.3 8 bp overlap

Motif ES_0h ES_0h-MZF1_MA0056.3 8 bp overlap

NANOG 10 datasets

ChIP GM23338 ENCFF065NZG 275 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 177 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 469 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 411 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 223 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 305 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 236 bp overlap

ChIP hESC GSE20650.NANOG.hESC 214 bp overlap

ChIP hESC GSE18292.NANOG.hESC 104 bp overlap

NCAPH2 1 dataset

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 460 bp overlap

NOTCH3 1 dataset

ChIP TALL-1_GSI GSE104261.NOTCH3.TALL-1_GSI 178 bp overlap

NR1H4::RXRA 2 datasets

Motif DE_12h DE_12h-NR1H4RXRA_MA1146.2 13 bp overlap

Motif ES_0h ES_0h-NR1H4RXRA_MA1146.2 13 bp overlap

NR2F1 2 datasets

Motif DE_12h DE_12h-NR2F1_MA1538.1 15 bp overlap

Motif ES_0h ES_0h-NR2F1_MA1538.1 15 bp overlap

NR2F6 2 datasets

Motif DE_12h DE_12h-NR2F6_MA1539.1 15 bp overlap

Motif ES_0h ES_0h-NR2F6_MA1539.1 15 bp overlap

NR4A2::RXRA 2 datasets

Motif DE_12h DE_12h-NR4A2RXRA_MA1147.2 13 bp overlap

Motif ES_0h ES_0h-NR4A2RXRA_MA1147.2 13 bp overlap

ChIP GM12878 ENCSR000BHJ.PAX5.GM12878 251 bp overlap

POLR2A 6 datasets

ChIP GM19099 ENCFF726IBN 442 bp overlap

ChIP GM23338 ENCFF450WCS 469 bp overlap

ChIP H1 ENCFF566JSR 469 bp overlap

ChIP H1 ENCFF833NJP 411 bp overlap

ChIP Raji ENCFF613VGX 150 bp overlap

ChIP spleen ENCFF044PYR 327 bp overlap

POU1F1 2 datasets

Motif DE_12h DE_12h-POU1F1_MA0784.3 14 bp overlap

Motif ES_0h ES_0h-POU1F1_MA0784.3 14 bp overlap

POU2F1 4 datasets

Motif DE_12h DE_12h-POU2F1_MA0785.2 9 bp overlap

Motif DE_12h DE_12h-POU2F1_MA0785.2 9 bp overlap

Motif ES_0h ES_0h-POU2F1_MA0785.2 9 bp overlap

Motif ES_0h ES_0h-POU2F1_MA0785.2 9 bp overlap

POU2F1::SOX2 4 datasets

Motif DE_12h DE_12h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif DE_12h DE_12h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif ES_0h ES_0h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif ES_0h ES_0h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F2 5 datasets

Motif DE_12h DE_12h-POU2F2_MA0507.3 13 bp overlap

Motif ES_0h ES_0h-POU2F2_MA0507.3 13 bp overlap

ChIP GM12878 ENCFF207RKY 321 bp overlap

ChIP GM12891 ENCFF166YPP 310 bp overlap

ChIP GM12891 ENCSR000BII.POU2F2.GM12891 182 bp overlap

POU2F3 5 datasets

Motif DE_12h DE_12h-POU2F3_MA0627.3 9 bp overlap

Motif DE_12h DE_12h-POU2F3_MA0627.3 9 bp overlap

Motif ES_0h ES_0h-POU2F3_MA0627.3 9 bp overlap

Motif ES_0h ES_0h-POU2F3_MA0627.3 9 bp overlap

ChIP NCI-H1048 GSE115123.POU2F3.NCI-H1048 260 bp overlap

POU3F1 2 datasets

Motif DE_12h DE_12h-POU3F1_MA0786.2 10 bp overlap

Motif ES_0h ES_0h-POU3F1_MA0786.2 10 bp overlap

POU3F2 2 datasets

Motif DE_12h DE_12h-POU3F2_MA0787.1 12 bp overlap

Motif ES_0h ES_0h-POU3F2_MA0787.1 12 bp overlap

POU3F3 2 datasets

Motif DE_12h DE_12h-POU3F3_MA0788.1 13 bp overlap

Motif ES_0h ES_0h-POU3F3_MA0788.1 13 bp overlap

POU3F4 4 datasets

Motif DE_12h DE_12h-POU3F4_MA0789.1 9 bp overlap

Motif DE_12h DE_12h-POU3F4_MA0789.1 9 bp overlap

Motif ES_0h ES_0h-POU3F4_MA0789.1 9 bp overlap

Motif ES_0h ES_0h-POU3F4_MA0789.1 9 bp overlap

POU5F1 12 datasets

ChIP BG03 GSE21614.POU5F1.BG03 153 bp overlap

Motif DE_12h DE_12h-POU5F1_MA1115.2 7 bp overlap

Motif DE_12h DE_12h-POU5F1_MA1115.2 7 bp overlap

Motif ES_0h ES_0h-POU5F1_MA1115.2 7 bp overlap

Motif ES_0h ES_0h-POU5F1_MA1115.2 7 bp overlap

ChIP GM23338 ENCFF333SNB 311 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 469 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 212 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 469 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 332 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 250 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 242 bp overlap

POU5F1B 4 datasets

Motif DE_12h DE_12h-POU5F1B_MA0792.1 9 bp overlap

Motif DE_12h DE_12h-POU5F1B_MA0792.1 9 bp overlap

Motif ES_0h ES_0h-POU5F1B_MA0792.1 9 bp overlap

Motif ES_0h ES_0h-POU5F1B_MA0792.1 9 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 265 bp overlap

PRDM9 2 datasets

Motif DE_12h DE_12h-PRDM9_MA1723.2 20 bp overlap

Motif ES_0h ES_0h-PRDM9_MA1723.2 20 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_12h DE_12h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif ES_0h ES_0h-Pou5f1Sox2_MA0142.1 15 bp overlap

RAD21 2 datasets

ChIP H1 ENCFF698EWO 241 bp overlap

ChIP HCT-116 GSE131606.RAD21.HCT-116 173 bp overlap

RBBP5 2 datasets

ChIP H1 ENCFF905HFL 329 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 418 bp overlap

RBPJ 2 datasets

ChIP MUTUL GSE75503.RBPJ.MUTUL 309 bp overlap

ChIP NHEK GSE29498.RBPJ.NHEK 109 bp overlap

RUNX3 2 datasets

Motif DE_12h DE_12h-RUNX3_MA0684.3 8 bp overlap

Motif ES_0h ES_0h-RUNX3_MA0684.3 8 bp overlap

ChIP WA01 ENCSR000BJW.RXRA.WA01 167 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 227 bp overlap

SIN3A 3 datasets

ChIP WA01 ENCSR000EBO.SIN3A.WA01 134 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 130 bp overlap

ChIP hiPSC_IB12 GSE106870.SIN3A.hiPSC_IB12 146 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 258 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 298 bp overlap

SMARCB1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 228 bp overlap

SMARCC1 2 datasets

ChIP hiPSC GSE124903.SMARCC1.hiPSC 166 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 271 bp overlap

ChIP HCT-116 GSE131606.SMC1.HCT-116 178 bp overlap

SNAI1 2 datasets

Motif DE_12h DE_12h-SNAI1_MA1558.2 7 bp overlap

Motif ES_0h ES_0h-SNAI1_MA1558.2 7 bp overlap

SNAI3 2 datasets

Motif DE_12h DE_12h-SNAI3_MA1559.2 9 bp overlap

Motif ES_0h ES_0h-SNAI3_MA1559.2 9 bp overlap

SOX10 2 datasets

Motif DE_12h DE_12h-SOX10_MA0442.3 6 bp overlap

Motif ES_0h ES_0h-SOX10_MA0442.3 6 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 334 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 284 bp overlap

Motif DE_12h DE_12h-SP5_MA1965.2 6 bp overlap

Motif ES_0h ES_0h-SP5_MA1965.2 6 bp overlap

TAF1 2 datasets

ChIP H1 ENCFF478SZO 464 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 408 bp overlap

ChIP H1 ENCFF859IIO 308 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 375 bp overlap

ChIP hESC GSE122298.TBP.hESC 413 bp overlap

ChIP hESC_10h GSE122298.TBP.hESC_10h 297 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 126 bp overlap

ChIP hESC_8h GSE122298.TBP.hESC_8h 174 bp overlap

ChIP hiPSC_WTa_RNase-neg GSE128135.TBP.hiPSC_WTa_RNase-neg 336 bp overlap

TCF12 5 datasets

Motif DE_12h DE_12h-TCF12_MA1648.2 7 bp overlap

Motif ES_0h ES_0h-TCF12_MA1648.2 7 bp overlap

ChIP GM12878 ENCSR000BGZ.TCF12.GM12878 102 bp overlap

ChIP H1 ENCFF203EBH 228 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 390 bp overlap

TCF3 4 datasets

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

Motif ES_0h ES_0h-TCF3_MA0522.4 7 bp overlap

ChIP NPC GSE154479.TCF3.NPC 469 bp overlap

ChIP Ramos GSE139810.TCF3.Ramos 190 bp overlap

TCF4 2 datasets

Motif DE_12h DE_12h-TCF4_MA0830.3 8 bp overlap

Motif ES_0h ES_0h-TCF4_MA0830.3 8 bp overlap

ChIP hESC_DIFF GSE39912.TP53.hESC_DIFF 329 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 142 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 207 bp overlap

ChIP WTC11 ENCFF139JAW 87 bp overlap

ChIP H1 ENCFF524BTL 337 bp overlap

ChIP WA01 GSE39096.YY1.WA01 171 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 161 bp overlap

ZEB1 3 datasets

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

Motif ES_0h ES_0h-ZEB1_MA0103.4 6 bp overlap

ChIP GM12878 ENCSR000BND.ZEB1.GM12878 399 bp overlap

ZKSCAN1 1 dataset

ChIP K-562 ENCSR882ERE.ZKSCAN1.K-562 149 bp overlap

ZNF114 2 datasets

ChIP GM23338 ENCFF631OSW 163 bp overlap

ChIP GM23338 ENCSR555KFE.ZNF114.GM23338 216 bp overlap

ZNF135 2 datasets

Motif DE_12h DE_12h-ZNF135_MA1587.1 14 bp overlap

Motif ES_0h ES_0h-ZNF135_MA1587.1 14 bp overlap

ZNF317 1 dataset

ChIP WTC11 ENCFF537KXI 277 bp overlap

ZNF324 1 dataset

Motif ES_0h ES_0h-ZNF324_MA1977.2 14 bp overlap

ZNF35 2 datasets

Motif DE_12h DE_12h-ZNF35_MA2333.1 7 bp overlap

Motif ES_0h ES_0h-ZNF35_MA2333.1 7 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 394 bp overlap

ZNF547 2 datasets

Motif DE_12h DE_12h-ZNF547_MA2334.1 13 bp overlap

Motif ES_0h ES_0h-ZNF547_MA2334.1 13 bp overlap

ZNF778 1 dataset

ChIP HEK293T GSE78099.ZNF778.HEK293T 173 bp overlap