The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for ZNF778. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF778 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF778, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:88,810,968–88,812,892 | 405.6 kb | Distal (>10kb) Multiome HiCAR | 1059 | |
| chr16:88,940,964–88,942,110 | 275.8 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr16:89,093,591–89,094,129 | 123.9 kb | Distal (>10kb) Multiome | 694 | |
| chr16:89,167,237–89,167,783 | 50.1 kb | Distal (>10kb) Multiome | 740 | |
| chr16:89,170,902–89,172,416 | 46.1 kb | Distal (>10kb) Multiome | 464 | |
| chr16:89,200,493–89,202,260 | 15.9 kb | Distal (>10kb) Multiome | 598 | |
| chr16:89,217,337–89,217,960 | 15 bp | At TSS Multiome | 857 | |
| chr16:89,240,678–89,241,104 | 23.3 kb | Distal (>10kb) Multiome | 864 | |
| chr16:89,246,875–89,247,970 | 29.8 kb | Distal (>10kb) Multiome | 740 | |
| chr16:89,290,889–89,291,526 | 73.4 kb | Distal (>10kb) Multiome | 171 | |
| chr16:89,360,791–89,361,256 | 143.3 kb | Distal (>10kb) Multiome | 194 | |
| chr16:89,473,854–89,474,466 | 256.5 kb | Distal (>10kb) Multiome | 213 | |
| chr16:89,489,154–89,489,850 | 271.6 kb | Distal (>10kb) Multiome | 596 | |
| chr16:89,490,254–89,491,281 | 273.0 kb | Distal (>10kb) Multiome | 817 | |
| chr16:89,507,395–89,509,159 | 290.6 kb | Distal (>10kb) Multiome | 987 |
Genomic view of the ZNF778 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.