Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BRK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,843,116–9,844,397 | 271.7 kb | Distal (>10kb) Multiome | 787 | |
| chr3:9,862,465–9,863,231 | 252.8 kb | Distal (>10kb) Multiome | 581 | |
| chr3:9,890,247–9,891,058 | 225.1 kb | Distal (>10kb) Multiome | 969 | |
| chr3:9,902,504–9,903,128 | 212.9 kb | Distal (>10kb) Multiome | 396 | |
| chr3:9,914,983–9,916,160 | 200.4 kb | Distal (>10kb) Multiome | 668 | |
| chr3:9,916,644–9,917,412 | 198.6 kb | Distal (>10kb) Multiome | 519 | |
| chr3:9,932,470–9,934,327 | 182.9 kb | Distal (>10kb) Multiome | 1035 | |
| chr3:9,946,152–9,947,739 | 169.0 kb | Distal (>10kb) Multiome | 898 | |
| chr3:9,951,898–9,952,503 | 163.4 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 128.8 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 106.5 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 104.5 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 89.3 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 21 bp | At TSS Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 26.2 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 49.2 kb | Distal (>10kb) Multiome | 718 | |
| chr3:10,226,242–10,226,711 | 110.9 kb | Distal (>10kb) Multiome | 88 | |
| chr3:10,234,612–10,235,203 | 119.3 kb | Distal (>10kb) Multiome | 122 | |
| chr3:10,248,095–10,249,643 | 132.8 kb | Distal (>10kb) Multiome | 892 | |
| chr3:10,263,882–10,264,353 | 148.4 kb | Distal (>10kb) Multiome | 139 | |
| chr3:10,316,093–10,316,808 | 200.9 kb | Distal (>10kb) Multiome | 50 | |
| chr3:10,320,481–10,321,504 | 205.5 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the BRK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.