This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for GHRLOS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GHRLOS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GHRLOS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,986,547–9,987,409 | 298.8 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 276.6 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 274.5 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 259.4 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 170.1 kb | Distal (>10kb) Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 143.9 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 120.8 kb | Distal (>10kb) Multiome | 718 | |
| chr3:10,226,242–10,226,711 | 59.2 kb | Distal (>10kb) Multiome | 88 | |
| chr3:10,234,612–10,235,203 | 50.8 kb | Distal (>10kb) Multiome | 122 | |
| chr3:10,248,095–10,249,643 | 37.3 kb | Distal (>10kb) Multiome | 892 | |
| chr3:10,263,882–10,264,353 | 21.7 kb | Distal (>10kb) Multiome | 139 | |
| chr3:10,286,921–10,287,242 | 1.2 kb | Proximal (<10kb) | 145 | |
| chr3:10,292,794–10,293,066 | 7.0 kb | Proximal (<10kb) | 401 | |
| chr3:10,320,481–10,321,504 | 35.4 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the GHRLOS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.