The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for SEC13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:10,025,904–10,026,762 | 294.7 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 205.4 kb | Distal (>10kb) Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 179.3 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 156.2 kb | Distal (>10kb) Multiome | 718 | |
| chr3:10,226,242–10,226,711 | 94.6 kb | Distal (>10kb) Multiome | 88 | |
| chr3:10,234,612–10,235,203 | 86.1 kb | Distal (>10kb) Multiome | 122 | |
| chr3:10,248,095–10,249,643 | 72.7 kb | Distal (>10kb) Multiome | 892 | |
| chr3:10,263,882–10,264,353 | 57.0 kb | Distal (>10kb) Multiome | 139 | |
| chr3:10,316,093–10,316,808 | 4.6 kb | Proximal (<10kb) Multiome | 50 | |
| chr3:10,320,481–10,321,504 | 64 bp | At TSS Multiome | 955 | |
| chr3:10,553,625–10,554,141 | 232.7 kb | Distal (>10kb) Multiome | 121 |
Genomic view of the SEC13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.